The Expression and Significances of Cyclind1,P16 in Cutaneous Squamous Carcinoma_West China Medical Journal

Authors：

LI ling ¹ , YANG Hong ² , LI Ke ² , et al ²

1 Institute of Dermatology and Venereology of Sichuan Provincial Provincial People,s Hospital,Chengdu Sichuan 610072;2Department of Pathology,Sichuan Provincial Provincial People,s Hospital,Chengdu Sichuan 610072,China;

Corresponding author：

Keywords：

CyclinD1; P16; 皮肤鳞状细胞癌; 免疫组织化学

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目的:观察CyclinD1,P16在皮肤鳞状细胞癌组织中的表达,探讨CyclinD1,P16在皮肤鳞状细胞癌发生发展中的作用。方法:用免疫组织化学技术检测40例皮肤鳞癌石蜡包埋组织和10例正常皮肤组织的CyclinD1,P16表达。结果:CyclinD1在皮肤鳞癌组织中表达高于皮肤正常对照组,两者差异有显著统计学意义(P lt;0.01); P16在皮肤鳞癌组织中表达低于皮肤正常对照组,但两者差异无显著统计学意义(P gt;0.05);CyclinD1,P16在皮肤鳞癌中表达呈正相关性(r=0.782,P lt;0.01)。结论:CyclinD1在皮肤鳞状细胞癌组织中阳性表达上调,P16在皮肤鳞状细胞癌组织中阳性表达下调,CyclinD1,P16在皮肤鳞癌中表达呈正相关。

Citation： LI ling,YANG Hong,LI Ke,et al. The Expression and Significances of Cyclind1,P16 in Cutaneous Squamous Carcinoma. West China Medical Journal, 2009, 24(8): 2042-2044. doi: Copy

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1. 陈意生主编.肿瘤分子细胞生物学[M].北京:人民军医出版社,2002:291-308.
2. RESNITZKY D, GOSSEN M, BUJARD H,et al.l Acceleration of theG1/ S phase transition by expression of cyclinD1 and E with an inducible system[J]. MolCellBio, 1994, 14(3): 1669-1679.
3. 韦立蓓,濮德敏,尹伶.角化型外阴鳞状细胞癌中p16和cyclin D1蛋白的表达[J].临床与实验病理学杂志, 2007,23(5):617-618.
4. LUKAS J, AAGAARD L, STRAUSS M, et al. Oncogenic aberrations ofp16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control[J].Cancer Res, 1995,55:4818-4823.
5. OKAMI K, REED AL, CAIRNS P, et al. Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma[J]. Oncogene, 1999,18:3541-3545.
6. VICTORIA L, BROWN, CATHERINE A, et al. p16INK4a and p14ARF Tumor Suppressor Genes Are Commonly Inactivated in Cutaneous Squamous Cell Carcinoma[J]. Journal of Investigative Dermatology, 2004,122: 1284-1292.
7. 张继刚.P16、CyclinD1在外阴鳞状上皮增生和外阴鳞癌中的表达及意义[J]. 西北国防医学杂志,2007,28(5):361-363.

West China Medical Journal

The Expression and Significances of Cyclind1,P16 in Cutaneous Squamous Carcinoma

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