Investigation of IL-0 Level in Serum and Influencing Factors in Patients with Rheumatoid Arthritis_West China Medical Journal

Authors：

PU Xiaoying , YANG Nanping , LI Min.

the Department of Clinical Immunology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

YANG Nanping, Email:

Keywords：

关节炎,类风湿; 白介素-20; 酶标记免疫吸附测定

Video：

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目的:探讨类风湿关节炎患者疾病活动与血清中白介素-20(IL-20)水平的关系。方法:用酶标记免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)方法检测60例类风湿关节炎患者及30例正常对照者外周血血清中IL-20水平。分析IL-20水平与RA发病和类风湿因子(rheumatoid factor,RF)、C反应蛋白(C reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)及同期手X光片分期的相关性。结果:活动期类风湿关节炎患者外周血中IL-0水平明显高于正常对照组(P lt;0.1)。类风湿关节炎患者IL.0水平与其RF、CRP、血沉及同期手X光片分期无明显相关性(P gt;0.)。结论:活动期类风湿关节炎患者外周血中IL-20平明显高于正常对照组,但与RF、CRP、血沉及同期手X光片分期无明显相关性。IL-0可能参与类风湿关节炎的发病过程,提示需进一步研究。

Citation： PU Xiaoying,YANG Nanping,LI Min.. Investigation of IL-0 Level in Serum and Influencing Factors in Patients with Rheumatoid Arthritis. West China Medical Journal, 2009, 24(8): 2054-2056. doi: Copy

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1. BECKER N, NIETERS A, RITTGEN W. Single nucleotide polymorphismdisease relationships: statistical issues for the performance of association studies[J]. Mutat Res,2003,525:11-18.
2. 吕诚,赵林华,肖诚,等.类风湿关节炎患者外周血CD4+T淋巴细胞基因表达谱研究探讨[J].中华风湿病学杂志,2006,10(7):438-439.
3. NISHIMOTO N. Cytokine signal regulation and autoimmune disorders[J]. Autoimmunity,2005,38:359-367.
4. STEINER G S, MOLEN J S. Autoantibodies in rheumatoid arthritis and their clinical significance[J]. Arthritis Res,2002,4:S1-S5.
5. MIN S Y, HWANG S Y, PARK K S, et al. Induction of IL10producing CD4+ CD25+ T cells in animal model of collageninduced arthritis by oral administration of type Ⅱ collagen[J]. Arthritis Res Ther,2004,6(3):R213-R219.
6. BLUMBERG H, CONKLIN D, XU W F, et al. Interleukin 20: discovery, receptor identification, and role in epidermal function[J]. Cell,2001,104(1):9-19.
7. DUMOUTIER L, LEEMANS C, LEJEUNE D, et al. Cutting edge: STAT activation by IL19, IL-20 and mad27 through IL-20 receptor complexes of two types[J]. J Immunol,2001,167(7):3545-3549.
8. HSU Y H, LI H H, HSIEH M Y, et al. Function of Interleukin20 as a proinflammatory molecule in rheumatoid and experimental arthritis[J]. Arthritis Rheum,2006,54(9):2722-2733.
9. SCHETT G, TOHIDASTAKRAD M, SMOLEN J S, et al. Activation, differential localization, and regulation of the stressactivated protein kinases, extracellular signalregulated kinase, cJUNNterminal kinase, and p38 mitogen activated protein kinase, in synovial tissue and cells in rheumatoid arthritis[J]. Arthritis Rheum,2000,43:2501-2512.
10. 王妍敏,郑捷.白介素10家族的新成员:白介素20[J].国外医学·皮肤性病学分册,2003,29(2):117-119.

West China Medical Journal

Investigation of IL-0 Level in Serum and Influencing Factors in Patients with Rheumatoid Arthritis

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