Comparison of the efficacy of diacerein, Glucosamine Hydrochloride and Diclofenac in the Treatment of Osteoarthritis_West China Medical Journal

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1West China Hospital, Sichuan University; 2the Orthopedic Hospital of Sichuan Province, Chengdu 610041, China;

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Keywords：

双醋瑞因; 盐酸氨基葡萄糖; 双氯芬酸钠; 骨性关节炎

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目的:研究双醋瑞因联合盐酸氨基葡萄糖和双氯芬酸钠治疗骨性关节炎的可行性及安全性。方法:选取100例骨性关节炎患者,随机分入双醋瑞因组联合双氯芬酸钠组(A组)、盐酸氨基葡萄糖联合双氯芬酸钠组(B组)、单用双氯芬酸钠组(C组)和双醋瑞因组联合双氯芬酸钠和盐酸氨基葡萄糖组(D组)四组中,用药12周后观察治疗前后临床疗效和综合疗效评分。结果:1.四组治疗方案在VAS评分、关节疼痛度评分方面均有良好改善率;2D组治疗方案优于A、B、C三组。结论:双醋瑞因联合盐酸氨基葡萄糖和双氯芬酸钠治疗骨性关节炎是可行、安全、优效的方案。

Citation： LI Min,YANG Nanping,WEI Hao,et al.. Comparison of the efficacy of diacerein, Glucosamine Hydrochloride and Diclofenac in the Treatment of Osteoarthritis. West China Medical Journal, 2009, 24(8): 2067-2069. doi: Copy

1.	唐福林,张奉春,郑文洁,等.双醋瑞因治疗膝骨关节炎的疗效与安全性多中心对照研究[J].中华风湿病学杂志,2005,9(7):421-422.
2.	胥方元,杨南萍,谢其冰,等.白芍总苷与奈丁美酮治疗老年膝骨关节炎的比较[J].华西医学,2006,21(1):57-58.
3.	YARON M, SHIRAZI I, YARON I. Antiinterleukin1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures[J]. Osteoarthritis Cartilage,1999,7(3):272-280.
4.	DOMAGALA F, MARTIN G, BOGDANOWICZ P, et al. Inhibition of interleukin1 βinduced activation of MEK/ERK pathway and DNA binding of NFκ B and AP1: potential mechanism for Diacerein effects in osteoarthritis[J]. Biorheology,2006,43 (3-4):577-587.
5.	FELISAZN, BOUMEDIENE K, GHAYOR C, et al. Stimulating effect of diacerein on TGFβ1 and β2 expression in articular chondrocytes cultured with and without interleukin1[J]. Osteoarthritis Cartilage,1999,7(3):255-264.
6.	TAMURA T, KOSAKA N, ISHIWA J, et al. Rhein, an active metabolite of diacerein, downregulates the production of promatrix metalloproteinases1, 3, 9 and 13 and upregulates the production of tissue inhibitor of metalloproteinase1 in cultured rabbit articular chondrocytes[J]. Osteoarthritis Cartilage,2001,9(3):257-263.
7.	DOUGADOSM, NGUYEN M, BERDAH L, et al. Evaluation of the structuremodifying effects of diacerin in hip osteoarthritis: ECHODIAH, a threeyear, placebocontrolled trial[J]. Arthritis Rheum,2001,44(11):2539-2547.

1. 唐福林,张奉春,郑文洁,等.双醋瑞因治疗膝骨关节炎的疗效与安全性多中心对照研究[J].中华风湿病学杂志,2005,9(7):421-422.
2. 胥方元,杨南萍,谢其冰,等.白芍总苷与奈丁美酮治疗老年膝骨关节炎的比较[J].华西医学,2006,21(1):57-58.
3. YARON M, SHIRAZI I, YARON I. Antiinterleukin1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures[J]. Osteoarthritis Cartilage,1999,7(3):272-280.
4. DOMAGALA F, MARTIN G, BOGDANOWICZ P, et al. Inhibition of interleukin1 βinduced activation of MEK/ERK pathway and DNA binding of NFκ B and AP1: potential mechanism for Diacerein effects in osteoarthritis[J]. Biorheology,2006,43 (3-4):577-587.
5. FELISAZN, BOUMEDIENE K, GHAYOR C, et al. Stimulating effect of diacerein on TGFβ1 and β2 expression in articular chondrocytes cultured with and without interleukin1[J]. Osteoarthritis Cartilage,1999,7(3):255-264.
6. TAMURA T, KOSAKA N, ISHIWA J, et al. Rhein, an active metabolite of diacerein, downregulates the production of promatrix metalloproteinases1, 3, 9 and 13 and upregulates the production of tissue inhibitor of metalloproteinase1 in cultured rabbit articular chondrocytes[J]. Osteoarthritis Cartilage,2001,9(3):257-263.
7. DOUGADOSM, NGUYEN M, BERDAH L, et al. Evaluation of the structuremodifying effects of diacerin in hip osteoarthritis: ECHODIAH, a threeyear, placebocontrolled trial[J]. Arthritis Rheum,2001,44(11):2539-2547.

West China Medical Journal

Comparison of the efficacy of diacerein, Glucosamine Hydrochloride and Diclofenac in the Treatment of Osteoarthritis

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