Influence of the Sichuan Wenchuan Earthquake on Disease Activity in Patients with Systemic Lupus Erythematosus_West China Medical Journal

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he Department of Rheumatology and Immunology, The Center Hospital of Mianyang City, Mianyang Sichuan 621000, China;

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Keywords：

系统性红斑狼疮; 地震; 创伤后应激障碍

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目的:探讨5·12 四川汶川大地震对系统性红斑狼疮(SLE)病情活动性的影响,以及因地震造成的停药、感染、居住环境恶劣(长期紫外线照射)和创伤后应激障碍(posttraumatic stress disease,PTSD)与病情活动性的相关性。方法:分析41例重灾区(北川、平武、江油、安县)SLE患者地震前后实验室指标和临床表现变化情况,采用Logistic回归分析地震造成停药、感染、居住环境恶劣和PTSD四种因素对SLE病情活动性的影响。结果:41例SLE患者地震后有18例病情活动,其中有27%患者出现关节痛,24%出现颜面红斑,19.5%出现发热,22%合并狼疮肾炎，震后C3水平显著低于震前。震后6例患者感染,13例患者停药,16例患者长期居住于恶劣环境中,11例患者患PTSD。通过Logistic回归分析发现PTSD、停药、居住条件恶劣与地震后SLE患者病情活动相关。结论:地震可使一部分重灾区SLE患者病情出现活动,PTSD、停药、居住条件恶劣与SLE病情活动具有相关性。

Citation： DONG Jianling,YANG Jing,DONG Xianping,et al. Influence of the Sichuan Wenchuan Earthquake on Disease Activity in Patients with Systemic Lupus Erythematosus. West China Medical Journal, 2009, 24(8): 2073-2075. doi: Copy

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1. SAISOONG S, EIAMONG S, HANVIVATVONG O. Correlations between antinucleosome antibodies and antidoublestranded DNA antibodies, C3, C4 and clinical activity in lupus patients[J].Clin Exp Rheumatol,2006,24(1):51-58.
2. ASLANIDIS S, PYRPASOPOULOU A, KONTOTASIOS K, et al. Parvovirus B19 infection and systemic lupus erythematosus: Activation of an aberrant pathway?[J] Eur J Intern Med,2008,19(5):314-318.
3. TSAO C H, CHEN C Y, OU L S, et al. Risk factors of mortality for salmonella infection in systemic lupus erythematosus[J]. J Rheumatol,2002,29(6):1214-1218.
4. WEKKING E M, VINGERHOETS A J, VAN DAM A P, et al. Daily stressors and systemic lupus erythematosus: a longitudinal analysisfirst findings[J]. Psychother Psychosom,1991,55:108-113.
5. HINRICHSEN H, FOLSCH U, KIRCH W. Modulation of the immune response to stress in patients with systemic lupus erythematosus: review of recent studies[J]. Eur J Clin Invest,1992,22:21-25.
6. HAGHSHENAS H, GOODARZI M A, FARAJPOOR M, et al. Posttraumatic stress disorder among survivors of Bam earthquake 40 days after the event[J]. East Mediterr Health J,2006,12:S118-S125.
7. MONTAZERI A, BARADARAN H, OMIDVARI S, et al. Psychological distress among Bam earthquake survivors in Iran: a populationbased study[J]. BMC Public Health,2005,5:4.

West China Medical Journal

Influence of the Sichuan Wenchuan Earthquake on Disease Activity in Patients with Systemic Lupus Erythematosus

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