The Mechanisms of Endothelin-1 in Rat Paraquat Poisoning_West China Medical Journal

Authors：

Department of Emergency, Affilicated Hospital of North Sichuan Medical College,Nancong Sichuan 637000,China;

Corresponding author：

Keywords：

内皮素; 百草枯; 中毒

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:观察百草枯中毒大鼠血浆和肺组织匀浆中的内皮素-1的动态变化,探讨大鼠PQ中毒肺损伤的可能机制。方法:将雄性Wistar大鼠随机分成百草枯中毒组和生理盐水对照组,分别给予16mg/kg百草枯或等体积生理盐水腹腔内注射,并在给药后6、12、24和72 h处死大鼠,观察其一般表现、肺的病理变化。测定肺系数、肺组织匀浆和血浆中内皮素-1的含量。结果: 百草枯中毒后大鼠出现呼吸困难,活动能力下降,肺系数增加,并随时间变化,光镜下表现为肺出血、水肿等不同程度的肺损伤改变。血浆和组织匀浆中内皮素-1在中毒后与对照组大鼠比较明显升高,并随时间变化(P lt;0.01)。结论:在百草枯中毒肺损伤中,内皮素-1可能发挥了重要作用。

Citation： LIU Shiping,HE Qing.. The Mechanisms of Endothelin-1 in Rat Paraquat Poisoning. West China Medical Journal, 2009, 24(9): 2338-2340. doi: Copy

1.	YAMASHITA M, YAMASHITA M, ANDO Y. A long term follow up of lung function in survivors of paraquat poisoning[J]．Hum Exp Toxicol,2000,19:99-103．.
2.	PRIIT T, PAUL W. A cytokine reborn? endothelin1 in pulmonary inflammation and fibrosis[J]. Am J Respir Cell Mol Biol. 2000;23:7-10．.
3.	FAGAN K A, MCMURTRY I F, RODMAN D M. Role of endothelin1 in lung disease[J].Respir Res.2001;2:90-101．.
4.	DONAUBAUER B, BUSCH T, LACHMANN R, et al. Lowdose inhalation of an endothelinA receptor antagonist in experimental acute lung injury: ET1 plasma concentration and pulmonary inflammation[J]. Exp Biol Med, 2006,231(6):960-966.
5.	KIM H R, PARK B K, OH Y M, et al. Green tea extract inhibits paraquatinduced pulmonary fibrosis by suppression of oxidative stress and endothelinl expression[J]. Lung,2006,184(5):287-95.

West China Medical Journal

The Mechanisms of Endothelin-1 in Rat Paraquat Poisoning

Abstract Full text Figures/Tables Video References Cited by

Format

Content