外阴Paget病的临床特点与治疗分析_West China Medical Journal

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外阴上皮内瘤变; Paget病; 治疗

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目的:探讨外阴Paget病的临床特点及治疗方法。方法:回顾分析5例外阴Paget病的临床资料。结果:外阴Paget病5例,年龄45～75岁,平均67.4岁。4例绝经。5例中,3 例(60%) 以瘙痒为首发症状,2 例(40%)因外阴结节、皮损或湿疹样改变就诊。患者治疗以手术为主。其中3例行外阴单纯切除术,1例因一般情况较差及内科合并症,未行手术,给予放疗。1例患者行外阴广泛切除及腹股沟淋巴结清扫术,术后给予放疗。结论:外阴Paget病多见于绝经后患者,症状以瘙痒为主,有就诊延迟现象。治疗以手术为主,可选择外阴单纯切除术或局部病灶切除,伴有浸润性病变、合并腺癌或淋巴结转移者常需扩大手术范围,行外阴广泛切除。对不能手术的患者,可给予放疗。复发常见,患者均需终生随访。

Citation： 何跃寰. 外阴Paget病的临床特点与治疗分析. West China Medical Journal, 2009, 24(9): 2403-2404. doi: Copy

1.	SARMIENTO JM,WOLFF BG,BURGART LJ, et al. Paget’s disease of the perianal region: an aggressive disease [J]. Dis Colon Rectum, 1997, 40: 1187-1194.
2.	FANNING J,LAMBERT HC, HALE TM, et al. Paget’s disease of the vulva: p revalence of associated vulvar adenocarcinoma, invasive Paget’s disease, and recurrence after surgical excision[J]. Am J Obstet Gynecol, 1999, 180: 24-27.
3.	KODAMA S, KANEKO T, SAITO M, et al. A clinicopathologic study of 30 patients with Paget’s disease of the vulva[J]. Gynecol Oncol, 1995, 56: 63-70.
4.	TEBES S, CARDOSI R, HOFMANM. Paget’s disease of the vulvar[J]. Am J Obstet Gynecol, 2002, 187: 281-284.
5.	PARKER LP, PARKER JR, BODURKA BEVERS D, et al. Paget ’s disease of the vulva: pathology, pattern of involvement and p rognosis[J]. Gynecol Oncol, 2000, 77: 183-189.
6.	WILKINSON EJ,BROWN HM. Vulvar Paget disease of urothelial origin: a report of three cases and a p roposed classification of vulvar Paget disease[J]. Hum Pathol, 2002, 33: 549-557.

1. SARMIENTO JM,WOLFF BG,BURGART LJ, et al. Paget’s disease of the perianal region: an aggressive disease [J]. Dis Colon Rectum, 1997, 40: 1187-1194.
2. FANNING J,LAMBERT HC, HALE TM, et al. Paget’s disease of the vulva: p revalence of associated vulvar adenocarcinoma, invasive Paget’s disease, and recurrence after surgical excision[J]. Am J Obstet Gynecol, 1999, 180: 24-27.
3. KODAMA S, KANEKO T, SAITO M, et al. A clinicopathologic study of 30 patients with Paget’s disease of the vulva[J]. Gynecol Oncol, 1995, 56: 63-70.
4. TEBES S, CARDOSI R, HOFMANM. Paget’s disease of the vulvar[J]. Am J Obstet Gynecol, 2002, 187: 281-284.
5. PARKER LP, PARKER JR, BODURKA BEVERS D, et al. Paget ’s disease of the vulva: pathology, pattern of involvement and p rognosis[J]. Gynecol Oncol, 2000, 77: 183-189.
6. WILKINSON EJ,BROWN HM. Vulvar Paget disease of urothelial origin: a report of three cases and a p roposed classification of vulvar Paget disease[J]. Hum Pathol, 2002, 33: 549-557.

West China Medical Journal

外阴Paget病的临床特点与治疗分析

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