CHEN Lina 1 , XIAO Qin 2 , XIANG Chengfa. 3
  • 1Department of Pediatrics, Sichuan Academy of Medical Science and Provincial People’s Hospital, Chengdu Sichuan 610072 China; 2Chengdu Children’s Hospital, Chengdu 610016; 3Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu Sichuan 610041,ChinaCorresponding author: XIAO Qin;
儿童; 甲状腺炎; 自身免疫性children; thyroiditis; autoimmune
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摘要:目的: 探讨儿童慢性淋巴细胞性甲状腺炎的临床特点、诊断方法、治疗及预后。 方法 : 对77例CLT患儿的临床资料进行回顾性分析。 结果 : 77例CLT患儿男女比例1:67,平均年龄1021±233岁(5～15岁)。86％患儿有甲状腺肿大;初诊时表现甲亢患儿51例,甲低20例,甲功正常6例; TGAb阳性率的94％,TPOAb阳性率96％;1例甲状腺细针吸取细胞学检查诊断合并甲状腺乳头状癌。治疗随访1～39月,77例患儿中出现甲低37例。 结论 : 儿童CLT多见于青春期女性,儿童和青春期患者病初表现甲亢较成人多见,TGAb 和TPOAb是CLT诊断的重要指标,随着病程延长,表现甲低患儿比例逐渐增高。
Abstract: Objective: To study the clinical feature, diagnosis, treatment and prognosis of Chronic lymphocytic thyroiditis in children. Methods : Analyze the clinical data of 77 children with Chronic lymphocytic thyroiditis. Results : The proportion of men to women was 1:67 in all 77 children, and the mean age at diagnosis was 1021±233(age range 5~15 years). The percentage of positive TGAb and TPOAb were 94% and 96%, respectively in all the 77 children. One children was diagnosed Chronic lymphocytic thyroiditis coexistent with thyroid papillary carcinoma by FNAB. There were 37 children had hypothyrodism in all the 77 after 1～39 months. Conclusion : CLT is more frequent in females, and at the time of diagnosis more children and adolescents had hypethyrodism than adults. TGAb and TPOAb are important markers for the diagnosis of CLT. The percentage of children had hypothyrodism is increasing along with the course of disease.

Citation： CHEN Lina,XIAO Qin,XIANG Chengfa.. Clinical Analysis of 77 Children with Chronic Lymphocytic Thyroiditis. West China Medical Journal, 2009, 24(10): 2579-. doi: Copy