• 1.The phmarcy department, The Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan 646000, China;2. College of Pharmacy, Luzhou Medical College, Luzhou Sichuan 646000, China;
格列本脲; 不良反应; 文献分析glibenclamide; adverse reaction; literature analysis
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摘要:目的:调查格列本脲的10年来不良反应情况为临床上合理使用格列本脲提供参考。方法:检索近10年(1999~2009)维普中文科技期刊数据库报道的格列本脲的不良反应文献,进行统计、分析。结果:格列本脲不良反应表现较多,机制复杂,最常见的是低血糖,其次是肝功能损伤。结论:临床上应该重视格列本脲的不良反应情况,针对不同病人合理用药。
Abstract: Objective: To investigate the adverse reaction of glibenclamide in resent ten years so as to promote rational clinical glibenclamide Use. Methods: The adverse reaction reports in the vipdatabase (19992009) were summarized and investigated. Results:There exist complicated mechanism and lots of clinical symptoms of the adverse reaction of glibenclamide. The most common adverse reaction of glibenclamide is glycopenia. Conclusion: Great attention should be paid to adverse reactions of glibenclamide for rational drug use. Glibenclamide should be used according to physiological and pathological situation of patients.

Citation： ZOU Yuhong,WANG Guojun,YAO Xinyu.. Literature Analysis on Adverse Effects of Glibenclamide. West China Medical Journal, 2009, 24(11): 2974-2976. doi: Copy