Diagnosis and Treatment of Hepatocellular Carcinoma with Hypoglycemia_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

郝建朋 ¹ , 张鹏 ² , 姚俊超 ¹ , 郭大伟 ¹ , 孙文郁 ¹ , 梁健 ¹ ,  姜晓峰 ¹

Corresponding author：

姜晓峰, Email: jxf0426@hotmail.com

Keywords：

肝癌; 低血糖; 诊断; 治疗

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　探讨肝癌合并低血糖的诊断及治疗。
方法　对中国医科大学附属第四医院2010年1月至2013年4月期间收治的27例肝癌伴低血糖患者的临床资料进行回顾性分析。
结果　27例患者中转移性肝癌2例，原发性肝癌25例；其中伴肝硬变9例。所有患者均给予护肝、补充能量治疗；22例行手术治疗后血糖全部控制在正常或仅轻度升高，5例因肿瘤无法切除而放弃手术治疗，其中1例伴肝硬变肝癌患者2个月后再次低血糖症状发作后死亡。
结论　低血糖是肝癌少见的并发症，早期诊断及治疗有助于避免后遗症的发生并改善预后。

Citation： 郝建朋,张鹏,姚俊超,郭大伟,孙文郁,梁健,姜晓峰. Diagnosis and Treatment of Hepatocellular Carcinoma with Hypoglycemia. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(10): 1162-1164. doi: Copy

1.	Okushin K， Asaoka Y， Fukuda I， et al. IGF-II producing hepatocellular carcinoma treated with sorafenib：metabolic complications and a foresight to molecular targeting therapy to the IGF signal[J]. Case Rep Gastroenterol， 2012， 6(3)：784-789.
2.	Baertling F， Mayatepek E， Gerner P， et al. Liver cirrhosis in glycogen storage disease Ib[J]. Mol Genet Metab， 2013， 108(3)：198-200.
3.	Cherian AK， Briski KP. A2 noradrenergic nerve cell metabolic transducer and nutrient transporter adaptation to hypoglycemia：impact of estrogen[J]. J Neurosci Res， 2012， 90(7)：1347-1358.
4.	Froissart R， Piraud M， Boudjemline AM， et al. Glucose-6-phosphatase deficiency[J]. Orphanet J Rare Dis， 2011， 6：27.
5.	Matsuyama M， Sugiura S， Kakita A， et al. Hepatocellular carc-inoma arising from ectopic liver tissue in the spleen producinginsulin-like growth factor II[J]. Pathol Res Pract， 2011， 207(2)：124-126.
6.	Sorlini M， Benini F， Cravarezza P， et al. Hypoglycemia， an atypical early sign of hepatocellular carcinoma[J]. J GastrointestCancer， 2010， 41(3)：209-211.
7.	Gaudiani JL， Sabel AL， Mascolo M， et al. Severe anorexia nervosa：outcomes from a medical stabilization unit[J]. Int J Eat Disord， 2012， 45(1)：85-92.
8.	Lau CI， Wang HC， Hsu WC. Hypoglycemic encephalopathy as the initial presentation of hepatic tumor：a case report[J]. Neuro-logist， 2010， 16(3)：206-207.
9.	Cassiman D， Libbrecht L， Verslype C， et al. An adult malepatient with multiple adenomas and a hepatocellular carcinoma：mild glycogen storage disease typeⅠa[J]. J Hepatol， 2010， 53(1)：.
10.	Filippella M， Davì MV， Doveri G， et al. Hyperinsulinemic hypo-glycemia associated with ectopic Cushing’s syndrome due to a pancreatic endocrine tumor in a Type 2 diabetes mellitus patient：clinical implications of a rare association[J]. J Endocrinol Invest，.
11.	Elhomsy GC， Eranki V， Albert SG， et al. “Hyper-warburgism，” a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin’s lymphoma[J]. J Clin Endocrinol Metab， 2012， 97(12)：4311-4316.
12.	Córdoba J. New assessment of hepatic encephalopathy[J]. J Hepatol， 2011， 54(5)：1030-1040.
13.	Hsiao SY， Chen SF， Chang CC， et al. Central nervous system involvement in hepatocellular carcinoma：Clinical characteristics and comparison of intracranial and spinal metastatic groups[J]. J Clin Neurosci， 2011， 18(3) ：364-368.
14.	Cammu G， Vermeiren K， Lecomte P， et al. Perioperative blood glucose management in patients undergoing tumor hepatectomy[J]. J Clin Anesth， 2009， 21(5)：329-335.
15.	Kandil SB， Miksa M， Faustino EV. Control of serum glucose concentration in critical illness[J]. Curr Opin Pediatr， 2013， 25(3)：297-303.
16.	-217.
17.	， 34(3)：175-179.

1. Okushin K， Asaoka Y， Fukuda I， et al. IGF-II producing hepatocellular carcinoma treated with sorafenib：metabolic complications and a foresight to molecular targeting therapy to the IGF signal[J]. Case Rep Gastroenterol， 2012， 6(3)：784-789.
2. Baertling F， Mayatepek E， Gerner P， et al. Liver cirrhosis in glycogen storage disease Ib[J]. Mol Genet Metab， 2013， 108(3)：198-200.
3. Cherian AK， Briski KP. A2 noradrenergic nerve cell metabolic transducer and nutrient transporter adaptation to hypoglycemia：impact of estrogen[J]. J Neurosci Res， 2012， 90(7)：1347-1358.
4. Froissart R， Piraud M， Boudjemline AM， et al. Glucose-6-phosphatase deficiency[J]. Orphanet J Rare Dis， 2011， 6：27.
5. Matsuyama M， Sugiura S， Kakita A， et al. Hepatocellular carc-inoma arising from ectopic liver tissue in the spleen producinginsulin-like growth factor II[J]. Pathol Res Pract， 2011， 207(2)：124-126.
6. Sorlini M， Benini F， Cravarezza P， et al. Hypoglycemia， an atypical early sign of hepatocellular carcinoma[J]. J GastrointestCancer， 2010， 41(3)：209-211.
7. Gaudiani JL， Sabel AL， Mascolo M， et al. Severe anorexia nervosa：outcomes from a medical stabilization unit[J]. Int J Eat Disord， 2012， 45(1)：85-92.
8. Lau CI， Wang HC， Hsu WC. Hypoglycemic encephalopathy as the initial presentation of hepatic tumor：a case report[J]. Neuro-logist， 2010， 16(3)：206-207.
9. Cassiman D， Libbrecht L， Verslype C， et al. An adult malepatient with multiple adenomas and a hepatocellular carcinoma：mild glycogen storage disease typeⅠa[J]. J Hepatol， 2010， 53(1)：.
10. Filippella M， Davì MV， Doveri G， et al. Hyperinsulinemic hypo-glycemia associated with ectopic Cushing’s syndrome due to a pancreatic endocrine tumor in a Type 2 diabetes mellitus patient：clinical implications of a rare association[J]. J Endocrinol Invest，.
11. Elhomsy GC， Eranki V， Albert SG， et al. “Hyper-warburgism，” a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin’s lymphoma[J]. J Clin Endocrinol Metab， 2012， 97(12)：4311-4316.
12. Córdoba J. New assessment of hepatic encephalopathy[J]. J Hepatol， 2011， 54(5)：1030-1040.
13. Hsiao SY， Chen SF， Chang CC， et al. Central nervous system involvement in hepatocellular carcinoma：Clinical characteristics and comparison of intracranial and spinal metastatic groups[J]. J Clin Neurosci， 2011， 18(3) ：364-368.
14. Cammu G， Vermeiren K， Lecomte P， et al. Perioperative blood glucose management in patients undergoing tumor hepatectomy[J]. J Clin Anesth， 2009， 21(5)：329-335.
15. Kandil SB， Miksa M， Faustino EV. Control of serum glucose concentration in critical illness[J]. Curr Opin Pediatr， 2013， 25(3)：297-303.
16. -217.
17. ， 34(3)：175-179.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Diagnosis and Treatment of Hepatocellular Carcinoma with Hypoglycemia

Abstract Full text Figures/Tables Video References Cited by

Format

Content