Relationship Between Glasgow Prognostic Score， Liver Metastasis， and Prognosis of Rectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIAO Chunhong ^1,2 , XUE Huchen ¹ , Liu Hailiang ¹ , Sun Peiming ¹ , Sun Huiwei ¹ , NING Ning ¹ ,  DU Xiaohui. ¹

1.Department of General Surgery， Chinese PLA General Hospital， Beijing 100853， China;;
2.Department of General Surgery， Fuzhou General Hospital， PLA Nanjing Military Area Command， Fuzhou 350025， Fujian Province， China;

Corresponding author：

DU Xiaohui., Email: duxiaohui301@sina.com

Keywords：

Glasgow prognostic score; Rectal cancer; Liver metastasis; Prognosis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To analyze the relationship between Glasgow prognostic score （GPS）， liver metastasis， and prognosis of rectal caner.
Methods 　Clinical data of 223 patients with rectal cancer who underwent operation in Chinese PLA General Hospital from Jun. 2005 to Dec. 2011 were retrospectively analyzed， and the relationship between preoperative GPS score， liver metastasis， and prognosis of rectal cancer were analyzed.
Results 　Preoperative GPS score of patients with rectal cancer was related to invasion depth （P＜0.001）， vascular or lymphatic invasion （P＜0.001）， liver metastasis （P＜0.001）， TNM stage （P＜0.001）， levels of carcinoembryonic antigen （P=0.009）， levels of CA19-9（P＜0.001）， and levels of CA724 （P＜0.001）. Multivariate analysis results revealed that differentiation of tumor （poorly：OR=10.688）， vascular or lymphatic invasion （OR=4.918）， lymph node metastasis （OR=3.359）， and preoperative GPS score （score 2：OR=15.907） were related to liver metastasis；age （RR=2.121）， differentiation of tumor （poorly：RR=2.846）， invasion depth （RR=1.754）， TNM stage （stageⅡ：RR=7.447， stageⅢ：RR=9.030， stage Ⅳ：RR=13.325）， and preoperative GPS score （score 2：RR=2.471） were the independently prognostic factors of rectal cancer. The preo- perative GPS score were related with both liver metastasis and prognosis of rectal cancer.
Conclusion 　Preoperative GPS score is associated with liver metastasis of rectal cancer， and it is considered to be a useful predictor of postoperative prognosis in rectal cancer.

Citation： XIAO Chunhong,XUE Huchen,Liu Hailiang,Sun Peiming,Sun Huiwei,NING Ning,DU Xiaohui.. Relationship Between Glasgow Prognostic Score， Liver Metastasis， and Prognosis of Rectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(6): 620-626. doi: Copy

1.	黄志强. 实用临床普通外科学[M]. 北京：科学技术文献出版社， 2009：370-375.
2.	Manfredi S， Lepage C， Hatem C， et al. Epidemiology and management of liver metastases from colorectal cancer[J]. Ann Surg， 2006， 244(2)：254-259.
3.	Mcmillan DC， Crozier JE， Canna K， et al. Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer[J]. Int J Colorectal Dis， 2007， 22(8)：881-886.
4.	Furukawa K， Shiba H， Haruki K， et al. The Glasgow prognostic score is valuable for colorectal cancer with both synchronous and metachronous unresectable liver metastases[J]. Oncol Lett， 2012， 4(2)：324-328.
5.	Ishizuka M， Nagata H， Takagi K， et al. Inflammation-based prognostic system predicts survival after surgery for stage Ⅳ colorectal cancer[J]. Am J Surg， 2013， 205(1)：22-28.
6.	Miller G， Biernacki P， Kemeny NE， et al. Outcomes after resectionof synchronous or metachronous hepatic and pulmonary colorectal metastases[J]. J Am Coll Surg， 2007， 205(2)：231-238.
7.	Richards CH， Roxburgh CS， Anderson JH， et al. Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer[J]. Br J Surg， 2012， 99(2)：287-294.
8.	Wang JY， Lu CY， Chu KS， et al. Prognostic significance of pre- and postoperative serum carcinoembryonic antigen levels in patients with colorectal cancer[J]. Eur Surg Res， 2007， 39(4)：245-250.
9.	杨建光，李震，李晓霞，等. 直肠癌术后局部复发转移的临床病理因素分析[J]. 中国普外基础与临床杂志， 2012， 19(11)：1200-1203.
10.	Demaria S， Pikarsky E， Karin M， et al. Cancer and inflammation：promise for biologic therapy[J]. J Immunother， 2010， 33(4)：335-351.
11.	陈晓敏，刘文第. 炎症对肿瘤恶性生物学行为的影响[J]. 肿瘤基础与临床， 2008， 21(3)：271-273.
12.	吉登波，崔景荣. 肿瘤的发生、发展及治疗与炎症的关系[J]. 中国新药杂志， 2010， 19(17)：1551-1555.
13.	Nozoe T， Mori E， Takahashi I， et al. Preoperative elevation of serum C-reactive protein as an independent prognostic indicator of colorectal carcinoma[J]. Surg Today， 2008， 38(7)：597-602.
14.	Ishizuka M， Nagata H， Takagi K， et al. C-reactive protein is associated with distant metastasis of T3 colorectal cancer[J]. Anticancer Res， 2012， 32(4)：1409-1415.
15.	刘霄，唐菁，李笃军. C-反应蛋白在肿瘤发生发展中的作用[J]. 生命的化学， 2011， 31(6)：868-870.
16.	Koike Y， Miki C， Okugawa Y， et al. Preoperative C-reactive protein as a prognostic and therapeutic marker for colorectal cancer[J]. J Surg Oncol， 2008， 98(7)：540-544.
17.	Nakatsu T， Motoyama S， Maruyama K， et al. Tumoral CRPexpression in thoracic esophageal squamous cell cancers is associated with poor outcomes[J]. Surg Today， 2012， 42(7)：652-658.
18.	Woo Y， Hyung WJ， Obama K， et al. Elevated high-sensitivity C-reactive protein， a marker of advanced stage gastric cancer and postgastrectomy disease recurrence[J]. J Surg Oncol， 2012， 105(4)：405-409.
19.	Warschkow R， Tarantino I， Ukegjini K， et al. Diagnostic study and meta-analysis of C-reactive protein as a predictor of postoperative inflammatory complications after gastroesophageal cancer surgery[J]. Langenbecks Arch Surg， 2012， 397(5)：727-736.
20.	Shiba H， Furukawa K， Fujiwara Y， et al. Postoperative peak serum C-reactive protein predicts outcome of hepatic resection for hepatocellular carcinoma[J]. Anticancer Res， 2013， 33(2)：705-709.
21.	Gerhardt T， Milz S， Schepke M， et al. C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma[J]. World J Gastroenterol， 2006， 12(34)：5495-5500.
22.	Pine JK， Fusai KG， Young R， et al. Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas[J]. Eur J Surg Oncol， 2009， 35(6)：605-610.
23.	Lai CC， You JF， Yeh CY， et al. Low preoperative serum albuminin colon cancer：a risk factor for poor outcome[J]. Int J Colorectal Dis， 2011， 26(4)：473-481.
24.	Lohsiriwat V， Lohsiriwat D， Boonnuch W， et al. Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery[J]. World J Gastroenterol， 2008， 14(8)：1248-1251.
25.	魏宜胜，彭经，洪楚原，等. 结直肠癌术前低白蛋白血症的临床意义及预后分析[J]. 实用医学杂志， 2012， 28(5)：778-780.

1. 黄志强. 实用临床普通外科学[M]. 北京：科学技术文献出版社， 2009：370-375.
2. Manfredi S， Lepage C， Hatem C， et al. Epidemiology and management of liver metastases from colorectal cancer[J]. Ann Surg， 2006， 244(2)：254-259.
3. Mcmillan DC， Crozier JE， Canna K， et al. Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer[J]. Int J Colorectal Dis， 2007， 22(8)：881-886.
4. Furukawa K， Shiba H， Haruki K， et al. The Glasgow prognostic score is valuable for colorectal cancer with both synchronous and metachronous unresectable liver metastases[J]. Oncol Lett， 2012， 4(2)：324-328.
5. Ishizuka M， Nagata H， Takagi K， et al. Inflammation-based prognostic system predicts survival after surgery for stage Ⅳ colorectal cancer[J]. Am J Surg， 2013， 205(1)：22-28.
6. Miller G， Biernacki P， Kemeny NE， et al. Outcomes after resectionof synchronous or metachronous hepatic and pulmonary colorectal metastases[J]. J Am Coll Surg， 2007， 205(2)：231-238.
7. Richards CH， Roxburgh CS， Anderson JH， et al. Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer[J]. Br J Surg， 2012， 99(2)：287-294.
8. Wang JY， Lu CY， Chu KS， et al. Prognostic significance of pre- and postoperative serum carcinoembryonic antigen levels in patients with colorectal cancer[J]. Eur Surg Res， 2007， 39(4)：245-250.
9. 杨建光，李震，李晓霞，等. 直肠癌术后局部复发转移的临床病理因素分析[J]. 中国普外基础与临床杂志， 2012， 19(11)：1200-1203.
10. Demaria S， Pikarsky E， Karin M， et al. Cancer and inflammation：promise for biologic therapy[J]. J Immunother， 2010， 33(4)：335-351.
11. 陈晓敏，刘文第. 炎症对肿瘤恶性生物学行为的影响[J]. 肿瘤基础与临床， 2008， 21(3)：271-273.
12. 吉登波，崔景荣. 肿瘤的发生、发展及治疗与炎症的关系[J]. 中国新药杂志， 2010， 19(17)：1551-1555.
13. Nozoe T， Mori E， Takahashi I， et al. Preoperative elevation of serum C-reactive protein as an independent prognostic indicator of colorectal carcinoma[J]. Surg Today， 2008， 38(7)：597-602.
14. Ishizuka M， Nagata H， Takagi K， et al. C-reactive protein is associated with distant metastasis of T3 colorectal cancer[J]. Anticancer Res， 2012， 32(4)：1409-1415.
15. 刘霄，唐菁，李笃军. C-反应蛋白在肿瘤发生发展中的作用[J]. 生命的化学， 2011， 31(6)：868-870.
16. Koike Y， Miki C， Okugawa Y， et al. Preoperative C-reactive protein as a prognostic and therapeutic marker for colorectal cancer[J]. J Surg Oncol， 2008， 98(7)：540-544.
17. Nakatsu T， Motoyama S， Maruyama K， et al. Tumoral CRPexpression in thoracic esophageal squamous cell cancers is associated with poor outcomes[J]. Surg Today， 2012， 42(7)：652-658.
18. Woo Y， Hyung WJ， Obama K， et al. Elevated high-sensitivity C-reactive protein， a marker of advanced stage gastric cancer and postgastrectomy disease recurrence[J]. J Surg Oncol， 2012， 105(4)：405-409.
19. Warschkow R， Tarantino I， Ukegjini K， et al. Diagnostic study and meta-analysis of C-reactive protein as a predictor of postoperative inflammatory complications after gastroesophageal cancer surgery[J]. Langenbecks Arch Surg， 2012， 397(5)：727-736.
20. Shiba H， Furukawa K， Fujiwara Y， et al. Postoperative peak serum C-reactive protein predicts outcome of hepatic resection for hepatocellular carcinoma[J]. Anticancer Res， 2013， 33(2)：705-709.
21. Gerhardt T， Milz S， Schepke M， et al. C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma[J]. World J Gastroenterol， 2006， 12(34)：5495-5500.
22. Pine JK， Fusai KG， Young R， et al. Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of pancreas[J]. Eur J Surg Oncol， 2009， 35(6)：605-610.
23. Lai CC， You JF， Yeh CY， et al. Low preoperative serum albuminin colon cancer：a risk factor for poor outcome[J]. Int J Colorectal Dis， 2011， 26(4)：473-481.
24. Lohsiriwat V， Lohsiriwat D， Boonnuch W， et al. Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery[J]. World J Gastroenterol， 2008， 14(8)：1248-1251.
25. 魏宜胜，彭经，洪楚原，等. 结直肠癌术前低白蛋白血症的临床意义及预后分析[J]. 实用医学杂志， 2012， 28(5)：778-780.

Next Article
建立全国性先天性心脏病手术数据库，提高诊治水平——对《继发于先天性心脏病术后的主动脉瓣下狭窄手术矫治分析》的评论

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Glasgow Prognostic Score， Liver Metastasis， and Prognosis of Rectal Cancer

Abstract Full text Figures/Tables Video References Cited by

Next Article

Format

Content