Comparative Analysis of Mammographic Findings and Pathological Features of Phyllodes Tumor of Breast_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZENG Hanjiang , XU Zhongzi ,  YU Jianqun , ZHANG Lizhi , LUO Yi , HUANG Zixing

Department of Radiology， West China Hospital， Sichuan University， Chengdu 610041， Sichuan Province， China;

Corresponding author：

YU Jianqun, Email: cjr.yujianqun@vip.163.com

Keywords：

Breast; Phyllodes tumor; Mammography; Pathology

Video：

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Objective 　To investigate the mammographic appearance of breast phyllodes tumors and the relation- ship of mammographic appearance to clinicopathologic features， and to determine the differential characteristics and pathologic basis.
Methods 　The clinical and imaging ﬁndings of 28 patients with surgically conﬁrmed phyllodes tumors
from January 2010 to January 2013 were analyzed retrospectively. The radiological features were compared with path-
ology.
Results 　Seventeen benign， 8 intermediate， and 3 malignant phyllodes tumors were identified by the histopatho-
logic review. Mammography demonstrated the tumors as a mass lesion in 26 cases and asymmetric opacity in 2 cases. The tumors were 2.8-10.2cm in diameter. The difference of rate of intermediate and malignant phyllodes tumors and benign phyllodes tumors was not statistically significant between ≥3cm and ＜3cm in diameter （Ρ＞0.05）. Although all the tumors showed lobulated margins except for 4 cases in the benign phyllodes tumors， it was not a signiﬁcant ﬁnding
（Ρ＞0.05）. However， poorly defined borders in the malignant and intermediate phyllodes tumors were more frequent than those in the benign phyllodes tumors （Ρ＜0.05）. Abnormal blood vessels were seen in 2 cases of benign phyllodes tumors and calcification was seen in 1 case of benign phyllodes tumors， while 10 tumors were surrounded by a clear halo， of them 8 were the benign phyllodes tumors and 2 were the intermediate and malignant phyllodes tumors （Ρ＞0.05）.
Conclusions 　Mammographic features combined with clinical behavior can be helpful for early detection， but definite diagnosis and classification should be verified by histopathologic examination.

Citation： ZENG Hanjiang,XU Zhongzi,YU Jianqun,ZHANG Lizhi,LUO Yi,HUANG Zixing. Comparative Analysis of Mammographic Findings and Pathological Features of Phyllodes Tumor of Breast. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(8): 946-950. doi: Copy

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13.	周卫平，陈方满，刘世翠. 乳腺分叶状肿瘤的临床及钼靶X线分析[J]. 皖南医学院学报， 2008， 27(6)：434-437.
14.	D’Orsi CJ， Feldhaus L， Sonnenfeld M. Unusual lesions of the breast[J]. Radiol Clin North Am， 1983， 21(1)：67-80.
15.	Jellins J， Hughes C， Ryan J， et al. A comparative evaluation of a case of cystosarcoma phylloides：ultrasound， xeroradiography and thermography[J]. Radiology， 1977， 124(3)：803-804.
16.	Tan H， Zhang S， Liu H， et al. Imaging findings in phyllodes tumors of the breast[J]. Eur J Radiol， 2012， 81(1)：e62-e69.
17.	Jorge Blanco A， Vargas Serrano B， Rodríguez Romero R， et al. Phyllodes tumors of the breast[J]. Eur Radiol， 1999， 9(2)：356-360.
18.	赵玉梅，郎荣刚，韩鹏. 乳腺叶状肿瘤的X线表现及病理对照分析[J]. 实用放射学杂志， 2009， 25(4)：550-553.
19.	Page JE， Williams JE. The radiological features of phylloides tumour of the breast with clinico-pathological correlation[J]. Clin Radiol， 1991， 44(1)：8-12.
20.	龙威. 乳腺叶状肿瘤的影像学表现分析[J]. 中国临床医学影像杂志， 2012， 23(2)：113-115.
21.	葛玲玉，王丽君，许顺良，等. 乳腺叶状瘤的X线表现与病理特征[J]. 中华放射学杂志， 2002， 36(11)：977-980.
22.	胡永升. 现代乳腺影像诊断学[M]. 北京：科学出版社， 2001：45.
23.	Feder JM， de Paredes ES， Hogge JP， et al. Unusual breast lesions：radiologic-pathologic correlation[J]. Radiographics， 1999， 19 Spec No (1)：S11-S26.

1. Liberman L， Bonaccio E， Hamele-Bena D， et al. Benign and malignant phyllodes tumors：mammographic and sonographic findings[J]. Radiology， 1996， 198(1)：121-124.
2. WHO. Histological typing of breast tumors[A]//International histological classification of tumors[M]. 2nd ed. Geneva：WHO， 1981：19.
3. Tavassoli FA， Devilee P. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Breast and Female Genital Organs[M]. Lyon：IARC Press， 2003：268.
4. Berg WA， Raza S， Birdwell RL， et al. Diagnostic imaging：Breast. Part [M]. Utah： Amirsys Inc， 2006：166-176.
5. Rosen PP. Rosen’s breast pathology [M]. New York：LippinCott-Ray， 1996：155-172.
6. Gurrero MA， Ballard BR， Grau AM. Malignant phyllodes tumor of breast：review of the literature and case report of stromal overgrowth[J]. Surg Oncol， 2003， 12(1)：27.
7. Bapat K， Oropeza R， Sahoo S. Benign phyllodes tumor of the male breast[J]. Breast J， 2002， 8(2)：115-116.
8. Bartoli C， Zurrida SM， Clemente C. Phyllodes tumor in a male patient with bilateral gynaecomastia induced by oestrogen therapy for prostatic carcinoma[J]. Eur J Surg Oncol， 1991， 17(2)：215-217.
9. 李席如，马冰，王建东，等. 乳腺分叶状肿瘤8例报告[J]. 中华肿瘤防治杂志， 2007， 14(17)：1339-1340.
10. Yilmaz E， Sal S， Lebe B. Differentiation of phyllodes tumors versus fibroadenomas[J]. Acta radiol， 2002， 43(1)：34-39.
11. 廖嘉煦，李林. CR钼靶联合彩色多普勒超声检查对乳腺癌的诊断价值[J]. 实用医院临床杂志， 2010， 7(3)：57-59.
12. Rajan PB， Cranor ML， Rosen PP. Cystosarcoma phyllodes in adolescent girls and young women：a study of 45 patients[J]. Am J Surg Pathol， 1998， 22(1)：64-69.
13. 周卫平，陈方满，刘世翠. 乳腺分叶状肿瘤的临床及钼靶X线分析[J]. 皖南医学院学报， 2008， 27(6)：434-437.
14. D’Orsi CJ， Feldhaus L， Sonnenfeld M. Unusual lesions of the breast[J]. Radiol Clin North Am， 1983， 21(1)：67-80.
15. Jellins J， Hughes C， Ryan J， et al. A comparative evaluation of a case of cystosarcoma phylloides：ultrasound， xeroradiography and thermography[J]. Radiology， 1977， 124(3)：803-804.
16. Tan H， Zhang S， Liu H， et al. Imaging findings in phyllodes tumors of the breast[J]. Eur J Radiol， 2012， 81(1)：e62-e69.
17. Jorge Blanco A， Vargas Serrano B， Rodríguez Romero R， et al. Phyllodes tumors of the breast[J]. Eur Radiol， 1999， 9(2)：356-360.
18. 赵玉梅，郎荣刚，韩鹏. 乳腺叶状肿瘤的X线表现及病理对照分析[J]. 实用放射学杂志， 2009， 25(4)：550-553.
19. Page JE， Williams JE. The radiological features of phylloides tumour of the breast with clinico-pathological correlation[J]. Clin Radiol， 1991， 44(1)：8-12.
20. 龙威. 乳腺叶状肿瘤的影像学表现分析[J]. 中国临床医学影像杂志， 2012， 23(2)：113-115.
21. 葛玲玉，王丽君，许顺良，等. 乳腺叶状瘤的X线表现与病理特征[J]. 中华放射学杂志， 2002， 36(11)：977-980.
22. 胡永升. 现代乳腺影像诊断学[M]. 北京：科学出版社， 2001：45.
23. Feder JM， de Paredes ES， Hogge JP， et al. Unusual breast lesions：radiologic-pathologic correlation[J]. Radiographics， 1999， 19 Spec No (1)：S11-S26.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Comparative Analysis of Mammographic Findings and Pathological Features of Phyllodes Tumor of Breast

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