Study on Effects of Transcatheter Arterial Chemoembolization on Postoperative Recurrence and Survival Rates for Primary Liver Cancer Patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiangxiang , YU Hua , XIONG Jie , LIU Mingzhong , SUN Jianming , ZHAO Yu

The Second Department of Surgery， Central Hospital of Dazhou City， Dazhou 635000， Sichuan Province， China;

Corresponding author：

Keywords：

Primary liver cancer; Transcatheter arterial chemoembolization; Survival; Recurrence

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Objective 　To evaluate the impact of transcatheter arterial chemoembolization（TACE） on survival and tumor recurrence in patients with primary liver cancer， provide reference of clinical diagnosis and treatment for the primary liver cancer patients.
Methods 　Two hundred and twenty-two cases of primary liver cancer were divided into TACE group （n=110） and control group （n=110）， TACE was performed after operation in the TACE group， convention treatment was performed after operation in the control group. The survival and tumor recurrence rates were compared between the TACE group and control group.
Results 　The 1-， 2-， and 3-year survival rates were 83.64%， 56.36%，and 42.73% in the TACE group， respectively， which were 65.45%， 40.91%， and 21.82% in the control group，respectively. The differences were statistically significant （P＜0.05）. The 1-， 2-， and 3-year tumor recurrence rates were 20.91%， 54.55%， and 67.27% in the TACE group， respectively， which were 38.18%， 57.27%， and 70.91% in the control group， respectively. The 1-year tumor recurrence rate in the TACE group was significantly lower than that in the control group （P＜0.05）， but the differences of the 2- and 3-year recurrence rates were not statistically significant（P＞0.05）.
Conclusions 　TACE treatment for primary liver cancer patients can increase long-term survival， but can’t
decrease long-term recurrence.

Citation： WANG Xiangxiang,YU Hua,XIONG Jie,LIU Mingzhong,SUN Jianming,ZHAO Yu. Study on Effects of Transcatheter Arterial Chemoembolization on Postoperative Recurrence and Survival Rates for Primary Liver Cancer Patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(11): 1204-1207. doi: Copy

1.	张庆，吴力群，张顺，等. 原发性肝癌术后行肝动脉化疗栓塞治疗对患者生存及肿瘤复发的影响[J]. 中国现代普通外科进展， 2011， 14(2)：126-129.
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25.	文洁，朱德增. 中晚期原发性肝癌患者的危险因素分析[J]. 中国现代医学杂志， 2011， 21(7)：841-845.
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28.	， 18(4)：450-455.

1. 张庆，吴力群，张顺，等. 原发性肝癌术后行肝动脉化疗栓塞治疗对患者生存及肿瘤复发的影响[J]. 中国现代普通外科进展， 2011， 14(2)：126-129.
2. 张坤，江艺，张绍庚，等. 肝动脉化疗栓塞对原发性肝癌患者术后生存及肿瘤复发的影响[J]. 中国普通外科杂志， 2007， 16(3)：206-208.
3. 罗懿忠，区金锐. TNM分期评价肝癌术后TACE及预后的价值[J]. 广东医学， 2009， 30(11)：1701-1703.
4. Poon RT， Fan ST， Ng IO， et al. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma[J]. Cancer， 2000， 89(3)：500-507.
5. 钟妮，潘桂华，张华，等. 超选择性肝动脉灌注化疗栓塞术治疗中晚期肝癌经验总结(附67例报告)[J]. 当代医学， 2010， 16(31)：71-72.
6. Paterson DL， Ko WC， Von Gottberg A， et al. Internationalprospective study of Klebsiella pneumoniae bacteremia：implications of extended-spectrum beta-lactamase production in nosocomialinfections[J]. Ann Intern Med， 2004， 140(1)：26-32.
7. Bruix J， Hessheimer AJ， Forner A， et al. New aspects of diagnosis and therapy of hepatocellular carcinoma[J]. Oncogene， 2006， 25(27)：3848-3856.
8. Zhong JH， Li le Q， Wu LC. Lamivudine with or withoutadefovir dipivoxil for postoperative hepatocellular carcinoma[J]. Cochrane Database Syst Rev， 2011， (12)：CD008713.
9. Lu X， Zhao H， Yang H， et al. A prospective clinical study on early recurrence of hepatocellular carcinoma after hepatectomy[J]. J Surg Oncol， 2009， 100(6)：488-493.
10. 肖开银，彭民浩. 原发性肝癌合并门静脉癌栓的治疗进展[J]. 中国普外基础与临床杂志， 2012， 19(3)：259-265.
11. Izumi R， Shimizu K， Iyobe T， et al. Postoperative adjuvanthepatic arterial infusion of Lipiodol containing anticancer drugs in patients with hepatocellular carcinoma[J]. Hepatology， 1994， 20(2)：295-301.
12. Kwok PC， Lam TW， Lam PW， et al. Randomized controlled trial to compare the dose of adjuvant chemotherapy after curative resection of hepatocellular carcinoma[J]. J Gastroenterol Hepatol，.
13. Llovet JM， Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma：Chemoembolizationimproves survival[J]. Hepatology， 2003， 37(2)：429-442.
14. 钱智玲，崔世昌，王海燕. 双介入法治疗原发性肝癌疗效的临床研究[J]. 中国普外基础与临床杂志， 2008， 15(9)：686-689.
15. 何平，李金龙，陈勇，等. 中晚期肝癌联合介入治疗175例报道[J]. 中国普外基础与临床杂志， 2010， 17(6)：615-617.
16. 陈哲宇，卢武胜，严律南. 肝癌合并门静脉癌栓术后两种治疗方式比较[J]. 中国普外基础与临床杂志， 2012， 19(3)：252-255.
17. Meng MB， Cui YL， Lu Y， et al. Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma：a systematic review and meta-analysis[J]. Radiother Oncol， 2009， 92(2)：184-194.
18. Peng BG， He Q， Li JP， et al. Adjuvant transcatheter arterial chemoembolization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus[J]. Am J Surg， 2009， 198(3)：313-318.
19. 余正平，徐正铿，周为中，等. 原发性肝癌根治术后辅助肝动脉栓塞化疗预防肝内复发的疗效[J]. 实用医学杂志， 2009， 25(11)：1819-1821.
20. Liu Y， Yang R. Preoperative combined with postoperative chemoembolization can improve survival in patients with hepatocellular carcinoma：a single-center study[J]. J Vasc Interv Radiol， 2009， 20(4)：472-483.
21. Shin SW. The current practice of transarterial chemoembolizationfor the treatment of hepatocellular carcinoma[J]. Korean JRadiol， 2009， 10(5)：425-434.
22. Tung-Ping Poon R， Fan ST， Wong J. Risk factors， prevention， and management of postoperative recurrence after resection of hepatocellular carcinoma[J]. Ann Surg， 2000， 232(1)：10-24.
23. 陈晓泓，张博恒，殷欣，等. 肝细胞癌根治术后行辅助性肝动脉化疗栓塞对近期复发的作用[J]. 中华医学杂志， 2010， 90(12)：826-829.
24. Lau WY， Yu SC， Lai EC， et al. Transarterial chemoembolization for hepatocellular carcinoma[J]. J Am Coll Surg， 2006， 202(1)：155-168.
25. 文洁，朱德增. 中晚期原发性肝癌患者的危险因素分析[J]. 中国现代医学杂志， 2011， 21(7)：841-845.
26. Kubo S， Hirohashi K， Yamazaki O， et al. Effect of the presence of hepatitis B e antigen on prognosis after liver resection for hepatocellular carcinoma in patients with chronic hepatitis B[J]. World J Surg， 2002， 26(5)：555-560.
27. 吴育连，苏昆仑，董鑫，等. 肝癌切除术后早/晚期复发的危险因素与治疗[J]. 中华肝胆外科杂志， 2006， 12(6)：370-373.
28. ， 18(4)：450-455.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study on Effects of Transcatheter Arterial Chemoembolization on Postoperative Recurrence and Survival Rates for Primary Liver Cancer Patients

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