Compliance of Ischemic State Tissue on Stem Cells Derived Angiology for Secondary Blood Flow Remodeling_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GAO Xue ¹ , ZENG Xiyun ¹ , YANG Yong ²

1. Department of Care and Treatment for Cadre， The First People’s Hospital of Kunming， Kunming 650000， Yunnan Province， China;;
2. Yunnan Provincial Center of Vascular Surgery， The Fourth Affiliated Hospital of Kunming Medical University and Secondary People’s Hospital of Yunnan Province， Kunming 650021， Yunnan Province， China;

Corresponding author：

Keywords：

Ischemia; Stem cell; Blood flow remodeling

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the biological mechanism about autologous peripheral blood stem cell transplantation （ABSCT） derived neovascularization to lead and perfect the effect of ischemic state tissue of secondary blood flow remodeling.
Methods 　Forty-two patients with critical limbs ischemia and 42 limbs in all from Mar. 2005 to Dec. 2005 in Yunnan Provincial Center of Vascular Surgery were selected，who treated by endovascular repair and ABSCT at the first flow reconstruction and the secondary flow reconstruction，respectively. The preoperative and postoperative effect degrees of limbs regional blood flow from cutaneous covering，blood vessel，and blood were measured by multifunction monitoring device，dopplor ultrasound monitoring device，percutem oxygen partial pressure （TcPO2）monitoring device and digital subtraction angiography （DSA）. The follow-up time was in four year after ABSCT.
Results 　After ABSCT， the pain，cold or cool，and rest pain of leg were relieved. The distance of intermittent claudication after ABSCT was longer than that before ABSCT 〔（1 600.3±310.1） m versus （520.3±160.6） m，F=5.84，P＜
0.05〕. The foot pain and limbs insensible feeling easement rates were 100% after ABSCT. Compared with before
ABSCT，the objective effect indexes of limbs regional blood flow after ABSCT were significantly improved 〔skin temperature index：1.63±0.31 versus 1.22±0.23，F=4.69，P＜0.05； TcPO2：（37.61±9.52） mm Hg versus （30.63±4.54） mm Hg，F=5.72，P＜0.05；ankle-brachium index：0.93±0.23 versus 0.33±0.24，F=6.72，P＜0.05；photoplethysmography index：0.81±0.12 versus 0.23±0.05，F=5.68，P＜0.05；saturation of blood oxygen：（79.44±20.42）% versus （42.43±10.41）%，F=5.68，P＜0.05； DSA score：1.34±0.23 versus 0.21±0.03，F=4.89，P＜0.05〕.
Conclusions　 The results bly suggest that the ABSCT can promote blood flow remodeling in limbs ischemia，and stem cells derived neovascularization can significantly offer effective and permanent blood flow perfusions to the ischemic state
tissue，and this biological effect play an important role in the ischemic state tissue for secondary blood flow remodeling.

Citation： GAO Xue,ZENG Xiyun,YANG Yong. Compliance of Ischemic State Tissue on Stem Cells Derived Angiology for Secondary Blood Flow Remodeling. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(10): 1094-1097. doi: Copy

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9.	谷涌泉，郭连瑞，张建，等. 自体骨髓干细胞移植改善下肢严重缺血致运动功能障碍：15例报告[J]. 中国临床康复， 2004， 8(20)：3917-3919.
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1. Huang P， Li S， Han M， et al. Autologous transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes[J]. Diabetes Care， 2005， 28(9)：2155-2160.
2. 黄平平，李尚珠，韩明哲，等. 自体外周血干细胞移植治疗下肢动脉硬化性闭塞症[J]. 中华血液学杂志， 2003， 24(6)：308-311.
3. Oyibo SO， Jude EB， Tarawneh I， et al. A comparison of two diabetic foot ulcer classification systems： the Wagner and the University of Texas wound classification systems[J]. Diabetes Care， 2001， 24(1)： 84-88.
4. 汪忠镐，张建，谷涌泉. 血栓闭塞性脉管炎[M]. 北京：人民军医出版社， 2004：266-271.
5. Isner JM， Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization[J]. J Clin Invest， 1999， 103(9)： 1231-1236.
6. 杨镛，陆平，何晓明，等. 人自体干细胞移植在重症肢体缺血血流重建中的疗效与评价[J]. 中国普外基础与临床杂志， 2009， 16(2)：115-118.
7. 杨镛，罗开元，段志泉，等. 自体外周血干细胞移植重建缺血肢体血管功能的策略与问题[J]. 云南医药， 2005， 26(3B)：7.
8. 谷涌泉，张建，齐立行，等. 自体骨髓干细胞移植治疗慢性下肢缺血94例不同病变分期患者的效果比较[J]. 中国临床康复， 2005， 9(38)：7-10.
9. 谷涌泉，郭连瑞，张建，等. 自体骨髓干细胞移植改善下肢严重缺血致运动功能障碍：15例报告[J]. 中国临床康复， 2004， 8(20)：3917-3919.
10. 吴雁翔，杨晓凤，王红梅，等. 干细胞治疗下肢缺血性疾病疗效观察[J]. 中国修复重建外科杂志， 2005， 19(12)：1019-1021.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Compliance of Ischemic State Tissue on Stem Cells Derived Angiology for Secondary Blood Flow Remodeling

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