Objective To evaluate the safety and efficacy of potassium and magnesium supplement with potassium aspartate and magnesium aspartate injection in gastrointestinal surgery patients during absolute fasting．
Methods A multicenter randomized controlled clinical trial was conducted in 111 patients after gastrointestinal surgery. For trial group，56 patients were given potassium aspartate and magnesium aspartate injection （Panangin®） in half of the total potassium replenished dose and the rest half of the potassium replenished dose was given in 10% potassium chloride injection．For control group，55 patients were given 10% potassium chloride injection for the total dose of potassium replenished．Such treatments maintained five consecutive days after surgical operation．Clinical observations were performed until patients were discharged from the hospitals．
Results Before the intervention，there were no significant differences for the baseline between two groups （P＞0.05）．There was no significant difference for the serum potassium level between two groups （P＞0.05） after intervention．The amount of urinary potassium （mmol/24 h） for patients in the trial group was significantly lower than that in the control group during treatment after operation．The serum magnesium level of control group was much lower than that of control group （P＜0.05）. In the clinical observation process，no drug-related adverse event was observed．
Conclusions The supplementary effect of potassium and magnesium for potassium aspartate and magnesium aspartate injection in patients with gastrointestinal surgery during absolute fasting is significant，and superior to potassium chloride injection for potassium supplement．Potassium aspartate and magnesium aspartate injection is a safe and appropriate choice for patients with potassium depletion．
Citation：
CHEN Bo,QI Yumei,QIAO Qilu,ZHANG Ming,XU Dongping,ZHENG Ping,CHEN Yajun,XIAO Huijuan,QIN Xianpeng,YANG Ping,SHI Jirong,WU Xiaoting .. A Multicenter Randomized Controlled Clinical Trial on Potassium and Magnesium Supplementary Effects of Potassium Aspartate and Magnesium Aspartate Injection in Gastrointestinal Surgery Patients During Absolute Fasting. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 165-170. doi:
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罗志勇，申丽洁．腹部择期手术前后电解质变化及术后早期补钾对胃肠功能的影响[ J]．中国普外基础与临床杂志， 1999， 6(1)：38-40．.
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周彦明，杨甲梅．肝移植术后腹泻的相关病因及处理[ J]．中国普外基础与临床杂志，2007，14(2)：155-158．.
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Gennari FJ．Pathophysiology of metabolic alkalosis：a new classification based on the centrality of stimulated collecting duct ion transport[J]．Am J Kidney Dis，2011，58(4)：626-636. [4] Kim GH，Han JS.Therapeutic approach to hypokalemia[J]． Nephron，2002，92 Suppl 1：28-32.
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Phakdeekitcharoen B，Kreepala C，Boongird S．Urine Potassium per hour as a marker for renal Potassium losses[J]．J Med Assoc Thai，2011，94(11)：1337-1345.
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Pu J，Zhang C，Quan X，et al．Effects of Potassium aspartate and Magnesium on ventricular arrhythmia in ischemia-reperfusion rabbit heart[J]．J Huazhong Univ Sci Technolog Med Sci， 2008，28(5)：517-519.
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Piper SN，Kiessling AH，Suttner SW，et al．Prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (Inzolen)[J]．Thorac Cardiovasc Surg，2007，55(7)：418-423.
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Iezhitsa IN，Spasov AA，Zhuravleva NV，et al．Comparative study of the efficacy of Potassium Magnesium L-，D- and DL-aspartate stereoisomers in overcoming digoxin- and furosemideinduced Potassium and Magnesium depletions[J]．Magnes Res， 2004，17(4)：276-292.
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Weng HL，Wang BE，Jia JD，et al．Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection：a randomized controlled study[J]．Clin Gastroenterol Hepatol，2005， 3(8)：819-828.
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Ji B，Liu J，Liu M，et al．Effect of cold blood cardioplegia enriched with potassium-magnesium aspartate during coronary artery bypass grafting[J]．J Cardiovasc Surg (Torino)，2006，47(6)： 671-675.
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徐成浩．门冬氨酸钾镁治疗重度低钾血症疗效观察[ J]．中国当代医药，2010，17(6)：50．.
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江守军，刘群亮，葛卫宁．门冬氨酸钾镁在腹部术后补钾的临床疗效观察[ J]．中国全科医学，2010，13(30)：3438-3439．.
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Amirmokri P，Morgan P，Bastani B．Intra-peritoneal administration of Potassium and Magnesium：a practical method to supplement these electrolytes in peritoneal dialysis patients[J]．Ren Fail，2007，29(5)：603-605.
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Hayashi Y，Ohtani M，Sawa Y，et al．Initial，continuous and intermittent bolus cardioplegia administration：efficacy of potassium-chloride and magnesium-sulfate as minimal additives for minimally-diluted blood cardioplegia[J]．J Cardiovasc Surg (Torino)，2005，46(1)：61-68.
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Hayashi Y，Ohtani M，Sawa Y，et al．Minimally-diluted blood cardioplegia supplemented with Potassium and Magnesium for combination of‘initial，continuous and intermittent bolus’ administration[J]．Circ J，2004，68(5)：467-472.
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- 1. 罗志勇，申丽洁．腹部择期手术前后电解质变化及术后早期补钾对胃肠功能的影响[ J]．中国普外基础与临床杂志， 1999， 6(1)：38-40．.
- 2. 周彦明，杨甲梅．肝移植术后腹泻的相关病因及处理[ J]．中国普外基础与临床杂志，2007，14(2)：155-158．.
- 3. Gennari FJ．Pathophysiology of metabolic alkalosis：a new classification based on the centrality of stimulated collecting duct ion transport[J]．Am J Kidney Dis，2011，58(4)：626-636. [4] Kim GH，Han JS.Therapeutic approach to hypokalemia[J]． Nephron，2002，92 Suppl 1：28-32.
- 4. Phakdeekitcharoen B，Kreepala C，Boongird S．Urine Potassium per hour as a marker for renal Potassium losses[J]．J Med Assoc Thai，2011，94(11)：1337-1345.
- 5. Pu J，Zhang C，Quan X，et al．Effects of Potassium aspartate and Magnesium on ventricular arrhythmia in ischemia-reperfusion rabbit heart[J]．J Huazhong Univ Sci Technolog Med Sci， 2008，28(5)：517-519.
- 6. Piper SN，Kiessling AH，Suttner SW，et al．Prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (Inzolen)[J]．Thorac Cardiovasc Surg，2007，55(7)：418-423.
- 7. Iezhitsa IN，Spasov AA，Zhuravleva NV，et al．Comparative study of the efficacy of Potassium Magnesium L-，D- and DL-aspartate stereoisomers in overcoming digoxin- and furosemideinduced Potassium and Magnesium depletions[J]．Magnes Res， 2004，17(4)：276-292.
- 8. Weng HL，Wang BE，Jia JD，et al．Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection：a randomized controlled study[J]．Clin Gastroenterol Hepatol，2005， 3(8)：819-828.
- 9. Ji B，Liu J，Liu M，et al．Effect of cold blood cardioplegia enriched with potassium-magnesium aspartate during coronary artery bypass grafting[J]．J Cardiovasc Surg (Torino)，2006，47(6)： 671-675.
- 10. 徐成浩．门冬氨酸钾镁治疗重度低钾血症疗效观察[ J]．中国当代医药，2010，17(6)：50．.
- 11. 江守军，刘群亮，葛卫宁．门冬氨酸钾镁在腹部术后补钾的临床疗效观察[ J]．中国全科医学，2010，13(30)：3438-3439．.
- 12. Amirmokri P，Morgan P，Bastani B．Intra-peritoneal administration of Potassium and Magnesium：a practical method to supplement these electrolytes in peritoneal dialysis patients[J]．Ren Fail，2007，29(5)：603-605.
- 13. Hayashi Y，Ohtani M，Sawa Y，et al．Initial，continuous and intermittent bolus cardioplegia administration：efficacy of potassium-chloride and magnesium-sulfate as minimal additives for minimally-diluted blood cardioplegia[J]．J Cardiovasc Surg (Torino)，2005，46(1)：61-68.
- 14. Hayashi Y，Ohtani M，Sawa Y，et al．Minimally-diluted blood cardioplegia supplemented with Potassium and Magnesium for combination of‘initial，continuous and intermittent bolus’ administration[J]．Circ J，2004，68(5)：467-472.
