Characteristics of Diagnosis and Treatment for Rectal Cancer in The Young Patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

A Ruhan ^1,2 , WANG Xiaodong ¹ , LI Li. ¹

1. Department of Anal-Colorectal Surgery, West China Hospital, Sichuan University, Chengdu 610041,Sichuan Province, China;;
2. West China Medical School/West China Hospital MCQ Team, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

Keywords：

Young patient; Rectal cancer; Epidemiology; Diagnosis; Treatment

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Objective 　To explore the characteristics of diagnosis and treatment for the rectal cancer in the young patients （≤40 years）．
Methods 　The domestic and abroad literatures about the research on the progress of rectal cancer in the young patients were reviewed, the clinical data of patients with rectal cancer were compared between the young patients and the other age patients, the characteristics of diagnosis and treatment for the rectal cancer in the young patients were summarized．
Results 　The onsets of the young patients with rectal cancer were related to the diet，lifestyle, and genetic factors．Compared with the older patients, more later stage, higher percentage of poor differentiation, earlier lymph node metastasis were found in the young patients with rectal cancer．Rectal cancer of the young patients was often misdiagnosed and with a poor prognosis．Currently，surgery assisted with neoadjuvant therapy was generally acknowledged as a better method．
Conclusions 　It has specificity in epidemiology, pathology, treatment, prognosis, and so on for rectal cancer in the young patients, but surgery needs further research．

Citation： A Ruhan,WANG Xiaodong,LI Li.. Characteristics of Diagnosis and Treatment for Rectal Cancer in The Young Patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 228-231. doi: Copy

1.	董秋美, 郑伟华, 何友兼．老年结直肠癌与中青年结直肠癌临床病理特征对比分析 [J]．南方医科大学学报, 2010, 30(9)：2128-2130．.
2.	O’Connell JB, Maggard MA, Livingston EH, et al．Colorectal cancer in the young [J]．Am J Surg, 2004, 187(3)：343-348．.
3.	李清晨, 代文杰, 许军．青年期结直肠癌的临床特点及误诊分析 [J]．消化外科, 2006, 5(5)：377-379．.
4.	卢焕全, 周志伟, 万德森, 等．青年人结直肠癌283 例临床病理特征及预后分析 [J]．广东医学, 2008, 29(2)：265-267．.
5.	O’connell JB, Maggard MA, Liu JH, et al．Rates of colon and rectal cancers are increasing in young adults [J]．Am Surg, 2003,69(10)：866-872．.
6.	万德森．结直肠癌流行病学与预防 [J]．中国中西医结合外科杂志, 2011, 17(1)：3-7．.
7.	Stewart BW, Kleihues P．World Cancer Report [M]．Lyon：IARC press, 2003：198．.
8.	American Cancer Society．Global Cancer Facts & Figures [M]．Atlanta, GA：American Cancer Society, 2007：12．.
9.	张振亚, 赵泽贞．大肠癌流行病学研究现状及展望 [J]．肿瘤防治研究, 2000, 27(2)：154-156．.
10.	Paganell GM．Vitmin and cancer [J]．Cancer, 1992, 8：47．.
11.	李士芬．护理干预对中青年高血压病患者遵医行为的影响 [J].中外医学研究, 2010, 8(28)：108．.
12.	张翼耀, 曹苇, 过兆基, 等．青年直肠癌临床病理特征及误诊原因分析 [J]．临床肿瘤学杂志, 2007, 12(3)：218-220．.
13.	Burt RW．Familial risk and colorectal cancer [J]．Int J Cancer,1996, 25(4)：793-803．.
14.	Wilmink A．Overview of the epidemiology of colorectal cancer [J]．Dis Colon Rectum, 1997, 40(4)：483-493．.
15.	Boland CR, Thibodeau SN, Hamilton SR, et al．A National Cancer institute workshop on microsatellite instability for cancer detection and familial predisposition：development ofinternational criteria for the determination of microsatellite instability in colorectal cancer [J]．Cancer Res, 1998, 58(22)：5248-5257．.
16.	于志坚．结直肠癌肝转移的现代治疗 [J]．南通大学学报( 医学版), 2010, 30(2)：132-135．.
17.	Parkin DM, Bray F, Ferlay J, et al．Global cancer statistics,2002 [J]．CA Cancer J Clin, 2005, 55(2)：74-108．.
18.	姚建根, 毛跃, 焦兰龙, 等．青年人结直肠癌38 例临床分析 [J].现代肿瘤医学, 2008, 16(1)：89-90．.
19.	黄明德．37 例青年人结肠直肠癌临床分析 [J]．亚太传统医药,2010, 6(5)：94-95．.
20.	保红平, 方登华, 高瑞岗, 等．青年人结直肠癌临床病理分析[J]．中国普外基础与临床杂志, 2004, 11(1)：52-54．.
21.	朱军, 王剑, 罗吉．青年期大肠癌临床分析 [J]．消化外科,2003, 2(6)：419-420．.
22.	Durno C, Aronson M, Bapat B, et al．Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma [J]．Gut, 2005, 54(8)：1146-1150．.
23.	Wong P, Verselis SJ, Garber JE, et al．Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome [J]．Gastroenterology, 2006, 130(1)：73-79．.
24.	张亚历, 聂军, 周杰, 等．中国青年大肠癌的发病特点及地理分布 [J]．中华消化内镜杂志, 1997, 14(1)：12-15．.
25.	杨福祥, 姜南．青年大肠癌48 例临床分析 [J]．实用医学杂志, 2007, 23(9)：1373-1374．.
26.	贾兴芳, 刘成霞．青年人结直肠癌101 例临床病理特征分析[J]．滨州医学院学报, 2008, 31(6)：426-428．.
27.	赖金火, 周永建, 卢辉山, 等．青年人直肠癌肝转移高危因素分析 [J]．中国医师进修杂志, 2009, 32(20)：13-16．.
28.	Endreseth BH, Romundstad P, Myrvold HE, et al．Rectal cancer in the young patient [J]．Dis Colon Rectum, 2006, 49(7)：993-1001．.
29.	谢正勇, 卿三华．国人青年结直肠癌解剖部位分布及临床病理特点 [J]．世界华人消化杂志, 2003, 11(10)： 1511-1514．.
30.	李立, 汪晓东, 舒晔, 等．四川大学华西医院? 结直肠癌手术治疗指南( 一) [J]．中国普外基础与临床杂志, 2008, 15(10)：778．.
31.	宏志, 张传珉, 张涌泉, 等．青年人结直肠癌71 例临床分析[J]．结直肠肛门外科, 2009, 15(6)：398-402．.
32.	汪晓东, 曹霖, 曾天芳, 等．多学科协作诊治模式下新辅助/辅助化疗联合结直肠癌手术的临床效果 [J]．中国普外基础与临床杂志, 2008, 15(8)：615-619．.
33.	汪晓东, 刘春娟, 陈增蓉, 等．多学科协作诊治模式下新辅助化疗联合手术治疗结直肠癌患者的生存质量评估 [J]．中国普外基础与临床杂志, 2008, 15(5）：371-374．.
34.	郁宝铭, 吴唯勤．新辅助化放疗与TME 联合治疗局部进展期低位直肠癌 [J]．中国实用外科杂志, 2005, 25(5)：270-272．.
35.	Crane CH, Skibber JM, Feig BW, et al．Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma [J]．Cancer, 2003, 97(2)：517-524．.
36.	Bosset JF, Calais G, Daban A, et al；EORTC Radiotherapy Group. Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients：assessment of acute toxicity and treatment compliance．Report of the 22 921 randomised trial conducted by the EORTC Radiotherapy Group [J]．Eur J Cancer, 2004,40(2)：219-224．.
37.	Levin KE, Dozois RR．Epidemiology of large bowel cancer [J]．World J Surg, 1991, 15(5)：562-567．.
38.	陈峻青．重视大肠癌复发、转移的临床研究 [J]．中国实用外科杂志, 2002, 22(6)：321．.

1. 董秋美, 郑伟华, 何友兼．老年结直肠癌与中青年结直肠癌临床病理特征对比分析 [J]．南方医科大学学报, 2010, 30(9)：2128-2130．.
2. O’Connell JB, Maggard MA, Livingston EH, et al．Colorectal cancer in the young [J]．Am J Surg, 2004, 187(3)：343-348．.
3. 李清晨, 代文杰, 许军．青年期结直肠癌的临床特点及误诊分析 [J]．消化外科, 2006, 5(5)：377-379．.
4. 卢焕全, 周志伟, 万德森, 等．青年人结直肠癌283 例临床病理特征及预后分析 [J]．广东医学, 2008, 29(2)：265-267．.
5. O’connell JB, Maggard MA, Liu JH, et al．Rates of colon and rectal cancers are increasing in young adults [J]．Am Surg, 2003,69(10)：866-872．.
6. 万德森．结直肠癌流行病学与预防 [J]．中国中西医结合外科杂志, 2011, 17(1)：3-7．.
7. Stewart BW, Kleihues P．World Cancer Report [M]．Lyon：IARC press, 2003：198．.
8. American Cancer Society．Global Cancer Facts & Figures [M]．Atlanta, GA：American Cancer Society, 2007：12．.
9. 张振亚, 赵泽贞．大肠癌流行病学研究现状及展望 [J]．肿瘤防治研究, 2000, 27(2)：154-156．.
10. Paganell GM．Vitmin and cancer [J]．Cancer, 1992, 8：47．.
11. 李士芬．护理干预对中青年高血压病患者遵医行为的影响 [J].中外医学研究, 2010, 8(28)：108．.
12. 张翼耀, 曹苇, 过兆基, 等．青年直肠癌临床病理特征及误诊原因分析 [J]．临床肿瘤学杂志, 2007, 12(3)：218-220．.
13. Burt RW．Familial risk and colorectal cancer [J]．Int J Cancer,1996, 25(4)：793-803．.
14. Wilmink A．Overview of the epidemiology of colorectal cancer [J]．Dis Colon Rectum, 1997, 40(4)：483-493．.
15. Boland CR, Thibodeau SN, Hamilton SR, et al．A National Cancer institute workshop on microsatellite instability for cancer detection and familial predisposition：development ofinternational criteria for the determination of microsatellite instability in colorectal cancer [J]．Cancer Res, 1998, 58(22)：5248-5257．.
16. 于志坚．结直肠癌肝转移的现代治疗 [J]．南通大学学报( 医学版), 2010, 30(2)：132-135．.
17. Parkin DM, Bray F, Ferlay J, et al．Global cancer statistics,2002 [J]．CA Cancer J Clin, 2005, 55(2)：74-108．.
18. 姚建根, 毛跃, 焦兰龙, 等．青年人结直肠癌38 例临床分析 [J].现代肿瘤医学, 2008, 16(1)：89-90．.
19. 黄明德．37 例青年人结肠直肠癌临床分析 [J]．亚太传统医药,2010, 6(5)：94-95．.
20. 保红平, 方登华, 高瑞岗, 等．青年人结直肠癌临床病理分析[J]．中国普外基础与临床杂志, 2004, 11(1)：52-54．.
21. 朱军, 王剑, 罗吉．青年期大肠癌临床分析 [J]．消化外科,2003, 2(6)：419-420．.
22. Durno C, Aronson M, Bapat B, et al．Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma [J]．Gut, 2005, 54(8)：1146-1150．.
23. Wong P, Verselis SJ, Garber JE, et al．Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome [J]．Gastroenterology, 2006, 130(1)：73-79．.
24. 张亚历, 聂军, 周杰, 等．中国青年大肠癌的发病特点及地理分布 [J]．中华消化内镜杂志, 1997, 14(1)：12-15．.
25. 杨福祥, 姜南．青年大肠癌48 例临床分析 [J]．实用医学杂志, 2007, 23(9)：1373-1374．.
26. 贾兴芳, 刘成霞．青年人结直肠癌101 例临床病理特征分析[J]．滨州医学院学报, 2008, 31(6)：426-428．.
27. 赖金火, 周永建, 卢辉山, 等．青年人直肠癌肝转移高危因素分析 [J]．中国医师进修杂志, 2009, 32(20)：13-16．.
28. Endreseth BH, Romundstad P, Myrvold HE, et al．Rectal cancer in the young patient [J]．Dis Colon Rectum, 2006, 49(7)：993-1001．.
29. 谢正勇, 卿三华．国人青年结直肠癌解剖部位分布及临床病理特点 [J]．世界华人消化杂志, 2003, 11(10)： 1511-1514．.
30. 李立, 汪晓东, 舒晔, 等．四川大学华西医院? 结直肠癌手术治疗指南( 一) [J]．中国普外基础与临床杂志, 2008, 15(10)：778．.
31. 宏志, 张传珉, 张涌泉, 等．青年人结直肠癌71 例临床分析[J]．结直肠肛门外科, 2009, 15(6)：398-402．.
32. 汪晓东, 曹霖, 曾天芳, 等．多学科协作诊治模式下新辅助/辅助化疗联合结直肠癌手术的临床效果 [J]．中国普外基础与临床杂志, 2008, 15(8)：615-619．.
33. 汪晓东, 刘春娟, 陈增蓉, 等．多学科协作诊治模式下新辅助化疗联合手术治疗结直肠癌患者的生存质量评估 [J]．中国普外基础与临床杂志, 2008, 15(5）：371-374．.
34. 郁宝铭, 吴唯勤．新辅助化放疗与TME 联合治疗局部进展期低位直肠癌 [J]．中国实用外科杂志, 2005, 25(5)：270-272．.
35. Crane CH, Skibber JM, Feig BW, et al．Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma [J]．Cancer, 2003, 97(2)：517-524．.
36. Bosset JF, Calais G, Daban A, et al；EORTC Radiotherapy Group. Preoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients：assessment of acute toxicity and treatment compliance．Report of the 22 921 randomised trial conducted by the EORTC Radiotherapy Group [J]．Eur J Cancer, 2004,40(2)：219-224．.
37. Levin KE, Dozois RR．Epidemiology of large bowel cancer [J]．World J Surg, 1991, 15(5)：562-567．.
38. 陈峻青．重视大肠癌复发、转移的临床研究 [J]．中国实用外科杂志, 2002, 22(6)：321．.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Characteristics of Diagnosis and Treatment for Rectal Cancer in The Young Patients

Abstract Full text Figures/Tables Video References Cited by

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