Expression and Clinical Significance of The Chemokine Receptor CCR7 in Thyroid Papillary Microcarcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHAI Jixin ^1,2 , HE QINGqing ² , ZHUANG DAyong ² , ZHENG LUming ² , XI CHENhui ² , ZHU Jian ²

1.Postgraduate Training Base， Jinan Military General Hospital， Liaoning Medical College， Jinan 250031， Shandong Province， China;;
2. Department of Thyroid and Breast Surgery， Jinan Military General Hospital， Jinan 250031， Shandong Province，China;

Corresponding author：

Keywords：

Chemokine receptor CCR7; Thyroid papillary microcarcinoma; Thyroid papillary carcinoma; Lymph node metastasis

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Objective 　To explore the expression of chemokine receptor CCR7 in thyroid papillary microcarcinoma tissues and the relationship with clinicopathological features.
Methods 　The CCR7 expressions in 31 cases of thyroid papillary microcarcinoma, 34 cases of thyroid papillary carcinoma which diameter＞1cm, 34 cases of nodular goiter, and 12 cases of thyroid papillary microcarcinoma contralateral normal thyroid tissues were detected by using immunohistochemistry S-P method.
Results 　The expression positive rates of CCR7 in thyroid papillary microcarcinoma and papillary thyroid carcinoma which diameter＞ 1cm were both 100%, the difference had not statistically significant （P＞0.05）. In nodular goiter and normal thyroid tissues, the expression positive rate of CCR7 was 64.7% and 33.3%, respectively, and compared with thyroid papillary microcarcinoma, the difference had statistically significant （P＜0.05）. There were not relations between the expression of CCR7 and patient’s gender, age, capsule invasion, and lymph node metastasis （P＞0.05）.
Conclusions 　The CCR7 in thyroid papillary microcarcinoma and thyroid papillary carcinoma which diameter＞ 1cm are both high expressions, and have the same bionomics, both prone to cervical lymph node meta-stasis, and the radical neck dissection （central area） are both need to take.

Citation： CHAI Jixin,HE QINGqing,ZHUANG DAyong,ZHENG LUming,XI CHENhui,ZHU Jian. Expression and Clinical Significance of The Chemokine Receptor CCR7 in Thyroid Papillary Microcarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(4): 372-376. doi: Copy

1.	Raman D， Baugher PJ， Thu YM， et al. Role of chemokines in tumor growth [J]. Cancer Lett， 2007， 256(2)： 137-165.
2.	Emmett MS， Lanati S， Dunn DB， et al. CCR7 mediates directed growth of melanomas towards lymphatics [J]. Microcirculation,2011， 18(3)： 172-182.
3.	Zhao B， Cui K， Wang CL， et al. The chemotactic interaction between CCL21 and its receptor， CCR7， facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis [J]. J Hepatobiliary Pancreat Sci， 2011 May 19.[Epub ahead of print].
4.	Li P， Liu F， Sun L， et al. Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3 [J]. Int J Mol Med， 2011， 27(5)： 679-687.
5.	Cunningham HD， Shannon LA， Calloway PA， et al. Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the lymph nodes in mice [J]. Transl Oncol， 2010，3(6)： 354-361.
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11.	熊斌，王崇树. 趋化因子受体CXCR4 和CCR7 在甲状腺癌中的表达及其临床病理意义 [J]. 中国普外基础与临床杂志，2011， 18(12)： 1301-1304.
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13.	Caglià P， Zappulla E， Costa S， et al. Differentiated thyroid cancer：role of the lymph node dissection [J]. G Chir， 2010， 31 (6-7)： 293-295.
14.	Chisholm EJ， Kulinskaya E， Tolley NS. Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone [J]. Laryngoscope， 2009， 119(6)： 1135-1139.
15.	Moo TA， Fahey TJ 3rd. Lymph node dissection in papillary thyroid carcinoma [J]. Semin Nucl Med， 2011， 41(2)： 84-88.
16.	贺青卿，庄大勇，郑鲁明，等. 全甲状腺切除加功能性颈淋巴结清扫治疗甲状腺乳头状癌172 例 [J]. 中华普通外科杂志，2010， 25( 8)： 611-615.
17.	贺青卿，庄大勇，魏金祥. 甲状腺乳头状癌外科治疗策略 [J].山东大学耳鼻喉眼学报， 2011， 25(5)： 7-10.
18.	贺青卿，崔玉宏，赵娟. 甲状腺乳头状微小癌的治疗策略 [J].中华内分泌外科杂志， 2010， 4(6)： 421-423.
19.	Cassier PA， Treilleux I， Bachelot T， et al. Prognostic value of the expression of C-Chemokine receptor 6 and 7 and their ligands in non-metastatic breast cancer [J]. BMC Cancer， 2011， 11：213.
20.	Liu Y， Ji R， Li J， et al. Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis [J]. J Exp Clin Cancer Res， 2010， 29(1)：1-9.
21.	Xu Y， Liu L， Qiu X， et al. CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells [J]. PLoS One， 2011， 6(6)： e21119.
22.	Zhen-jin Z， Peng L， Fa-yu L， et al. PKCα take part in CCR7/ NF-κB autocrine signaling loop in CCR7-positive squamous cell carcinoma of head and neck [J]. Mol Cell Biochem， 2011，357(1-2)： 181-187.
23.	Mburu YK， Egloff AM， Walker WH， et al. Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and AP1 in metastatic squamous cell carcinoma of the head and neck (SCCHN) [J]. J Biol Chem， 2012， 287(5)： 3581-3590.
24.	Sperveslage J， Frank S， Heneweer C， et al. Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma [J]. Int J Cancer， 2011 Oct 23. doi：10.1002/ijc.26502.[ Epub ahead of print].
25.	Ishigami S， Natsugoe S， Nakajo A， et al. Prognostic value of CCR7 expression in gastric cancer[ J]. Hepatogastroenterology，2007， 54(76)： 1025-1028.
26.	Schaeuble K， Hauser MA， Singer E， et al. Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration [J]. J Immunol， 2011， 187(11)： 5645-5652.
27.	Kliche S， Worbs T， Wang X， et al. CCR7-mediated LFA-1 functions in T cells are regulated by two independent ADAP/SKAP55-modules [J]. Blood， 2012， 119(3)： 777-785.
28.	Issa A， Le TX， Shoushtari AN， et al. Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor celllymphatic cross-talk promote invasive phenotype [J]. Cancer Res， 2009， 69(1)： 349-357.
29.	Wu X，Lee VC， Chevalier E， et al. Chemokine receptors as targets for cancer therapy [J]. Curr Pharm Des， 2009， 15(7)：742-757.

1. Raman D， Baugher PJ， Thu YM， et al. Role of chemokines in tumor growth [J]. Cancer Lett， 2007， 256(2)： 137-165.
2. Emmett MS， Lanati S， Dunn DB， et al. CCR7 mediates directed growth of melanomas towards lymphatics [J]. Microcirculation,2011， 18(3)： 172-182.
3. Zhao B， Cui K， Wang CL， et al. The chemotactic interaction between CCL21 and its receptor， CCR7， facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis [J]. J Hepatobiliary Pancreat Sci， 2011 May 19.[Epub ahead of print].
4. Li P， Liu F， Sun L， et al. Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3 [J]. Int J Mol Med， 2011， 27(5)： 679-687.
5. Cunningham HD， Shannon LA， Calloway PA， et al. Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the lymph nodes in mice [J]. Transl Oncol， 2010，3(6)： 354-361.
6. Pierceall WE， Wolfe M， Suschak J， et al. Strategies for H-score normalization of preanalytical technical variables with potential utility to immunohistochemical-based biomarker quantitation in therapeutic response diagnostics [J]. Anal Cell Pathol， 2011，34(3)： 159-168.
7. Kodama J， Hasengaowa， Kusumoto T， et al. Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer [J]. Ann Oncol，2007， 18(1)： 70-76.
8. Sancho M， Vieira JM， Casalou C， et al. Expression and function of the chemokine receptor CCR7 in thyroid carcinomas [J]. J Endocrinol， 2006， 191(1)： 229-238.
9. González HE， Leiva A， Tobar H， et al. Altered chemokine receptor expression in papillary thyroid cancer [J]. Thyroid，2009， 19(9)： 957-965.
10. Wagner PL， Moo TA， Arora N， et al. The chemokine receptors CXCR4 and CCR7 are associated with tumor size and pathologic indicators of tumor aggressiveness in papillary thyroid carcinoma[J]. Ann Surg Oncol， 2008， 15(10)： 2833-2841.
11. 熊斌，王崇树. 趋化因子受体CXCR4 和CCR7 在甲状腺癌中的表达及其临床病理意义 [J]. 中国普外基础与临床杂志，2011， 18(12)： 1301-1304.
12. 张华，田铧，吕顺增，等. CCR7 在甲状腺乳头状癌组织中的表达及意义 [J]. 中国现代普通外科进展， 2010， 13(11)： 852-854.
13. Caglià P， Zappulla E， Costa S， et al. Differentiated thyroid cancer：role of the lymph node dissection [J]. G Chir， 2010， 31 (6-7)： 293-295.
14. Chisholm EJ， Kulinskaya E， Tolley NS. Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone [J]. Laryngoscope， 2009， 119(6)： 1135-1139.
15. Moo TA， Fahey TJ 3rd. Lymph node dissection in papillary thyroid carcinoma [J]. Semin Nucl Med， 2011， 41(2)： 84-88.
16. 贺青卿，庄大勇，郑鲁明，等. 全甲状腺切除加功能性颈淋巴结清扫治疗甲状腺乳头状癌172 例 [J]. 中华普通外科杂志，2010， 25( 8)： 611-615.
17. 贺青卿，庄大勇，魏金祥. 甲状腺乳头状癌外科治疗策略 [J].山东大学耳鼻喉眼学报， 2011， 25(5)： 7-10.
18. 贺青卿，崔玉宏，赵娟. 甲状腺乳头状微小癌的治疗策略 [J].中华内分泌外科杂志， 2010， 4(6)： 421-423.
19. Cassier PA， Treilleux I， Bachelot T， et al. Prognostic value of the expression of C-Chemokine receptor 6 and 7 and their ligands in non-metastatic breast cancer [J]. BMC Cancer， 2011， 11：213.
20. Liu Y， Ji R， Li J， et al. Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis [J]. J Exp Clin Cancer Res， 2010， 29(1)：1-9.
21. Xu Y， Liu L， Qiu X， et al. CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells [J]. PLoS One， 2011， 6(6)： e21119.
22. Zhen-jin Z， Peng L， Fa-yu L， et al. PKCα take part in CCR7/ NF-κB autocrine signaling loop in CCR7-positive squamous cell carcinoma of head and neck [J]. Mol Cell Biochem， 2011，357(1-2)： 181-187.
23. Mburu YK， Egloff AM， Walker WH， et al. Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and AP1 in metastatic squamous cell carcinoma of the head and neck (SCCHN) [J]. J Biol Chem， 2012， 287(5)： 3581-3590.
24. Sperveslage J， Frank S， Heneweer C， et al. Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma [J]. Int J Cancer， 2011 Oct 23. doi：10.1002/ijc.26502.[ Epub ahead of print].
25. Ishigami S， Natsugoe S， Nakajo A， et al. Prognostic value of CCR7 expression in gastric cancer[ J]. Hepatogastroenterology，2007， 54(76)： 1025-1028.
26. Schaeuble K， Hauser MA， Singer E， et al. Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration [J]. J Immunol， 2011， 187(11)： 5645-5652.
27. Kliche S， Worbs T， Wang X， et al. CCR7-mediated LFA-1 functions in T cells are regulated by two independent ADAP/SKAP55-modules [J]. Blood， 2012， 119(3)： 777-785.
28. Issa A， Le TX， Shoushtari AN， et al. Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor celllymphatic cross-talk promote invasive phenotype [J]. Cancer Res， 2009， 69(1)： 349-357.
29. Wu X，Lee VC， Chevalier E， et al. Chemokine receptors as targets for cancer therapy [J]. Curr Pharm Des， 2009， 15(7)：742-757.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Clinical Significance of The Chemokine Receptor CCR7 in Thyroid Papillary Microcarcinoma

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