Analysis of Diagnosis and Treatment in 35 Patients with Gastrointestinal Stromal Tumors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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张剑 , 王昆华 , 龚昆梅 , 朱宇

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Keywords：

胃肠道间质瘤; 诊断; 手术治疗

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目的探讨胃肠道间质瘤的临床病理特点及治疗方法。方法回顾性分析我院2005年7月至2010年7月期间收治的35例患者的临床资料。结果35例患者病变分别位于胃部18例（51.4%），其中胃体15例（42.9%）、胃窦3例（8.6%）；回肠16例（45.7%）；小肠系膜根部1例（2.9%）。 35例均进行手术治疗，其中行胃楔形切除术15例（42.9%），胃大部切除术3例（8.6%），小肠部分切除术16例（45.7%），肠系膜肿块切除加大部分小肠切除术1例（2.9%）。术后病理报告均为间质瘤；免疫组织化学染色结果： CD117阳性33例(94.3%)，CD34阳性26例(74.3%)。 35例术后均获随访，随访时间6个月至5年，平均25.6个月。 1例术后10个月死于肿瘤复发，1例术后4个月死于短肠综合征、营养不良，余33例无肿瘤复发。结论胃肠道间质瘤确诊依赖于病理组织学检查及免疫组化染色，完整切除病灶是最有效的治疗手段。

Citation： 张剑,王昆华,龚昆梅,朱宇. Analysis of Diagnosis and Treatment in 35 Patients with Gastrointestinal Stromal Tumors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(11): 1220-1221. doi: Copy

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1. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic,immunohistochemical and moleucular genetic study of 1 765 cases with longterm followup [J]. Am J Surg Pathol, 2005, 29(1): 5268.
2. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach [J]. Hum Pathol, 2002, 33(5): 459465.
3. Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis [J]. Am J Surg Pathol, 1983, 7(6): 507519.
4. GichozLach H, KasztelanSzczerbinska B, Slomka M. Gastrointestinal stromal tumors: epidemiology, clinical picture, diagnosis, prognosis and treatment [J]. Pol Arch Med Wewn, 2008, 118(4): 216221.
5. Trent JC, Benjamin RS. New developments in gastrointestinal stromal tumor [J]. Curr Opin Oncol, 2006, 18(4): 386395.
6. 廖松林，高冬霞．胃肠道间质瘤的进展 [J]．实用医院临床杂志， 2004， 1（3）： 1314．.
7. 戎龙，万远廉，年卫东，等．胃间质瘤63 例临床分析 [J]．中华胃肠外科杂志， 2009， 12（1）： 2427．.
8. Mochizuki Y, Kodera Y, Ito S, et al. Treatment and risk factors for recurrence after curative resection of gastrointestinal stromal tumors of the stomach [J]. World J Surg, 2004, 28(9): 870875.
9. Carboni F, Carlini M, Scardamaglia F, et al. Gastrointestinal stromal tumors of the stomach. A tenyear surgical experience [J]. J Exp Clin Cancer Res, 2003, 22(3): 379384.
10. 王全红，王金桃，乔英，等．胃肠道间质瘤影像诊断 [M]．北京：人民卫生出版社， 2009： 5978．.
11. 白月奎，邵永孚，石素胜，等．胃肠道间质瘤预后多因素分析 [J]．中华肿瘤杂志， 2005， 27（10）： 598601．.
12. Samiian L, Weaver M, Velanovich V. Evaluation of gastrointestinal stromal tumors for recurrence rates and patterns of longterm followup [J]. Am Surg, 2004, 70(3): 187191.
13. 王刚，张汝鹏，赵敬柱，等． 132例胃的胃肠道间质瘤治疗及预后分析 [J]．中华胃肠外科杂志， 2010， 13（7）： 492496．.
14. Hornick JL, Fletcher CD. The role of KIT in the management of patients with gastrointestinal stromal tumors [J]. Hum Pathol, 2007, 38(5): 679687.
15. Benjamin RS, Blanke CD, Blay JY, et al. Management of gastrointestinal stromal tumors in the imatinib era: selected case studies [J]. Oncologist, 2006, 11(1): 920.
16. Andtbacka Rh, Ng CS, Sacife CL, et al. Surgical resection of gastrointestinal stromal tumors after treatment with imatinib [J]. Ann Surg Oncol, 2007, 14(1): 1424.
17. Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 2021 March 2004, under the auspices of ESMO [J]. Ann Oncol, 2005, 16(4): 566578.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Diagnosis and Treatment in 35 Patients with Gastrointestinal Stromal Tumors

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