Advance of Triggering Receptor Expressed on Myeloid Cells-1_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CAO Wenbin , ZHANG Guozhi , WANG Changyou.

Department of General Surgery, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China;

Corresponding author：

Keywords：

Triggering receptor expressed on myeloid cells1; Inflammation disease

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ObjectiveTo summarize the advance of triggering receptor expressed on myeloid cells-1 (TREM-1). MethodsLiteratures about the recent studies on the TREM-1 were reviewed. ResultsTREM1 was a mediator of inflammation. It could amplify the inflammation and lead to overexpression of inflammation in final. ConclusionTREM-1 is very important in development of many diseases and provide a new molecule target to cure.

Citation： CAO Wenbin,ZHANG Guozhi,WANG Changyou.. Advance of Triggering Receptor Expressed on Myeloid Cells-1. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(10): 1118-1121. doi: Copy

1.	Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM1, a novel receptor expressed on neutrophils and monocytes [J]. J Immunol, 2000, 164(10): 49914995.
2.	Nathan C, Ding A. TREM1: a new regulator of innate immunity in sepsis syndrome [J]. Nat Med, 2001, 7(5): 530532.
3.	Ho CC, Liao WY, Wang CY, et al. TREM1 expression in tumorassociated macrophages and clinical outcome in lung cancer [J]. Am J Respir Crit Care Med, 2008, 177(7): 763770.
4.	Mohamadzadeh M, Coberley SS, Olinger GG, et al. Activation of triggering receptor expressed on myeloid cells1 on human neutrophils by Marburg and Ebola viruses [J]. J Virol, 2006, 80(14): 72357244.
5.	Murakami Y, Akahoshi T, Hayashi I, et al. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals [J]. Arthritis Rheum, 2006, 54(2): 455462.
6.	Cavaillon JM. Monocyte TREM1 membrane expression in noninfectious inflammation [J]. Crit Care, 2009, 13(3): 152.
7.	Liao R, Liu Z, Wei S, et al. Triggering receptor in myeloid cells (TREM1) specific expression in peripheral blood mononuclear cells of sepsis patients with acute cholangitis [J]. Inflammation, 2009, 32(3): 182190.
8.	Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and metaanalysis [J]. Lancet Infect Dis, 2007, 7(3): 210217.
9.	Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells1 in host defense during the earlyinduced and adaptive phases of the immune response [J]. J Immunol, 2003, 170(7): 38123818.
10.	Rolli J, Loukili N, Levrand S, et al. Bacterial flagellin elicits wide spread innate immune defense mechanisms, apoptotic signaling, and a sepsislike systemic inflammatory response in mice [J]. Crit Care, 2010,14(4): R160.
11.	Sharma SM, Choi D, Planck SR, et al. Insights into the pathogenesis of axial spondyloarthropathy based on gene expression profiles [J]. Arthritis Res Ther, 2009, 11(6): R168.
12.	Jing JY, Huang TC, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells1 in bacterial infection: a metaanalysis [J]. Intensive Care Med, 2009, 35(4): 587595.
13.	Gibot S, Koloppsarda MN, Béné MC, et al. Plasma level of a triggering receptor expressed on myeloid cells1: its diagnostic accuracy in patients with suspected sepsis [J]. Ann Intern Med, 2004, 141(1): 915.
14.	Gibot S, Cravoisy A, KoloppSarda MN, et al. Timecourse of strem(soluble triggering receptor expressed on myeloid cells)1, procalcitonin, and Creactive protein plasma concentrations during sepsis [J]. Crit Care Med, 2005, 33(4): 792796.
15.	Wiersinga WJ, Veer CT, Wieland CW, et al. Expression profile and function of triggering receptor expressed on myeloid cells1 during melioidosis [J]. J Infect Dis, 2007, 196(11): 17071716.
16.	宋达疆, 黄晓元, 杨兴华, 等. 髓系触发受体1基因RNAi慢病毒载体的构建及功能初步检测 [J]. 中南大学学报（医学版）, 2009, 34(10): 970977.
17.	Bishara J, Hadari N, Shalitachesner M, et al. Soluble triggering receptor expressed on myeloid cells1 for distinguishing bacterial from aseptic meningitis in adults [J]. Eur J Clin Microbiol Infect Dis, 2007, 26(9): 647650.
18.	Determann RM, Weisfelt M, de Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis [J]. Intensive Care Med, 2006, 32(8): 12431247.
19.	Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis [J]. N Engl J Med, 2005, 352(19): 19922001.
20.	Ratjen F, Dring G. Cystic fibrosis [J]. Lancet, 2003, 361(9358): 681689.
21.	Sibley CD, Rabin H, Surette MG. Cystic fibrosis: a polymicrobial infectious disease [J]. Future Microbiol, 2006, 1(1): 5361.
22.	del Fresno C, GarciaRio F, GomezPina V, et al. Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharidetolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients [J]. Immunol, 2009, 182(10): 64946507.
23.	del Fresno C, Gómezpia V, Lores V, et al. Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: downregulation of TREM1 as putative underlying mechanism [J]. PLoS One, 2008, 3(7): e2667.
24.	Harada T, Yoshioka H, Yoshida S, et al. Increased interleukin6 levels in peritoneal fluid of infertile patients with active endometriosis [J]. Am J Obstet Gynecol, 1997, 176(3): 593597.
25.	钱如云，刘嘉茵． TREM1在子宫内膜异位症中的表达 [J]．生殖与避孕， 2007， 27（3）： 182185．.
26.	廖锐，沈克，冯虎翼，等．人髓样细胞触发性受体1在急性胆管炎的表达及意义 [J]．中华实验外科杂志， 2008， 25（10）： 12451247．.
27.	廖锐，刘作金，龚建平，等．人髓样细胞触发性受体1在急性梗阻性化脓性胆管炎外周血单核细胞中的表达 [J]．南方医科大学学报， 2009，29（11）： 21792181．.
28.	Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule (triggering receptor expressed on myeloid cells1) in the diagnosis of pleural effusion [J]. Respirology, 2007, 12(3): 333338.
29.	Huang LY, Shi HZ, Liang QL, et al. Expression of soluble triggering receptor expression on myeloid cells1 in pleural effusion [J]. Chin Med J (Engl), 2008, 121(17): 16561661.
30.	Luo L, Zhou Q, Chen XJ, et al. Effects of the TREM1 pathway modulation during empyema in rats [J]. Chin Med J (Engl), 2010, 123(12): 15611565.
31.	Porfyridis I, Plachouras D, Karagianni V, et al. Diagnostic value of triggering receptor expressed on myeloid cells1 and Creactive protein for patients with lung infiltrates:an observational study [J]. BMC Infect Dis, 2010, 10(1): 286.
32.	Oudhuis GJ, Beuving J, Bergmans D, et al. Soluble triggering receptor expressed on myeloid cells1in bronchoalveolar lavage fluid is not predictive for ventilatorassociated pneumonia [J]. Intensive Care Med, 2009, 35(7): 12651270.
33.	ElSolh AA, Akinnusi ME, Peter M, et al. Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes [J]. Intensive Care Med, 2008, 34(6): 10121019.
34.	Schenk M, Bouchon A, Seibold F, et al. TREM1expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases [J]. J Clin Invest, 2007, 117(10): 30973106.
35.	余文，吴伟，张少辉，等. 急性胰腺炎发病机理的研究进展 [J]. 中国普外基础与临床杂志, 2006, 13(6): 733736.
36.	Wang DY, Qin RY, Liu ZR, et al. Expression of TREM1 mRNA in acute pancreatitis [J]. World J Gastroenterol, 2004, 10(18): 27442746.
37.	邵子力，曹良启，彭和平，等．髓样细胞表达触发受体1在重症急性胰腺炎中的表达和意义 [J]．中华普通外科学文献（电子版）， 2010， 4（4）： 328331．.
38.	路筝．髓样细胞表达激发受体1（TREM1）对重症急性胰腺炎继发感染的诊断价值和分子治疗应用 [D]. 第二军医大学, 2008．.
39.	Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells1 in patients with acute pancreatitis [J]. Crit Care Med, 2008, 36(7): 20482053.

1. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM1, a novel receptor expressed on neutrophils and monocytes [J]. J Immunol, 2000, 164(10): 49914995.
2. Nathan C, Ding A. TREM1: a new regulator of innate immunity in sepsis syndrome [J]. Nat Med, 2001, 7(5): 530532.
3. Ho CC, Liao WY, Wang CY, et al. TREM1 expression in tumorassociated macrophages and clinical outcome in lung cancer [J]. Am J Respir Crit Care Med, 2008, 177(7): 763770.
4. Mohamadzadeh M, Coberley SS, Olinger GG, et al. Activation of triggering receptor expressed on myeloid cells1 on human neutrophils by Marburg and Ebola viruses [J]. J Virol, 2006, 80(14): 72357244.
5. Murakami Y, Akahoshi T, Hayashi I, et al. Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals [J]. Arthritis Rheum, 2006, 54(2): 455462.
6. Cavaillon JM. Monocyte TREM1 membrane expression in noninfectious inflammation [J]. Crit Care, 2009, 13(3): 152.
7. Liao R, Liu Z, Wei S, et al. Triggering receptor in myeloid cells (TREM1) specific expression in peripheral blood mononuclear cells of sepsis patients with acute cholangitis [J]. Inflammation, 2009, 32(3): 182190.
8. Tang BM, Eslick GD, Craig JC, et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and metaanalysis [J]. Lancet Infect Dis, 2007, 7(3): 210217.
9. Bleharski JR, Kiessler V, Buonsanti C, et al. A role for triggering receptor expressed on myeloid cells1 in host defense during the earlyinduced and adaptive phases of the immune response [J]. J Immunol, 2003, 170(7): 38123818.
10. Rolli J, Loukili N, Levrand S, et al. Bacterial flagellin elicits wide spread innate immune defense mechanisms, apoptotic signaling, and a sepsislike systemic inflammatory response in mice [J]. Crit Care, 2010,14(4): R160.
11. Sharma SM, Choi D, Planck SR, et al. Insights into the pathogenesis of axial spondyloarthropathy based on gene expression profiles [J]. Arthritis Res Ther, 2009, 11(6): R168.
12. Jing JY, Huang TC, Cui Wei, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells1 in bacterial infection: a metaanalysis [J]. Intensive Care Med, 2009, 35(4): 587595.
13. Gibot S, Koloppsarda MN, Béné MC, et al. Plasma level of a triggering receptor expressed on myeloid cells1: its diagnostic accuracy in patients with suspected sepsis [J]. Ann Intern Med, 2004, 141(1): 915.
14. Gibot S, Cravoisy A, KoloppSarda MN, et al. Timecourse of strem(soluble triggering receptor expressed on myeloid cells)1, procalcitonin, and Creactive protein plasma concentrations during sepsis [J]. Crit Care Med, 2005, 33(4): 792796.
15. Wiersinga WJ, Veer CT, Wieland CW, et al. Expression profile and function of triggering receptor expressed on myeloid cells1 during melioidosis [J]. J Infect Dis, 2007, 196(11): 17071716.
16. 宋达疆, 黄晓元, 杨兴华, 等. 髓系触发受体1基因RNAi慢病毒载体的构建及功能初步检测 [J]. 中南大学学报（医学版）, 2009, 34(10): 970977.
17. Bishara J, Hadari N, Shalitachesner M, et al. Soluble triggering receptor expressed on myeloid cells1 for distinguishing bacterial from aseptic meningitis in adults [J]. Eur J Clin Microbiol Infect Dis, 2007, 26(9): 647650.
18. Determann RM, Weisfelt M, de Gans J, et al. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis [J]. Intensive Care Med, 2006, 32(8): 12431247.
19. Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis [J]. N Engl J Med, 2005, 352(19): 19922001.
20. Ratjen F, Dring G. Cystic fibrosis [J]. Lancet, 2003, 361(9358): 681689.
21. Sibley CD, Rabin H, Surette MG. Cystic fibrosis: a polymicrobial infectious disease [J]. Future Microbiol, 2006, 1(1): 5361.
22. del Fresno C, GarciaRio F, GomezPina V, et al. Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharidetolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients [J]. Immunol, 2009, 182(10): 64946507.
23. del Fresno C, Gómezpia V, Lores V, et al. Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: downregulation of TREM1 as putative underlying mechanism [J]. PLoS One, 2008, 3(7): e2667.
24. Harada T, Yoshioka H, Yoshida S, et al. Increased interleukin6 levels in peritoneal fluid of infertile patients with active endometriosis [J]. Am J Obstet Gynecol, 1997, 176(3): 593597.
25. 钱如云，刘嘉茵． TREM1在子宫内膜异位症中的表达 [J]．生殖与避孕， 2007， 27（3）： 182185．.
26. 廖锐，沈克，冯虎翼，等．人髓样细胞触发性受体1在急性胆管炎的表达及意义 [J]．中华实验外科杂志， 2008， 25（10）： 12451247．.
27. 廖锐，刘作金，龚建平，等．人髓样细胞触发性受体1在急性梗阻性化脓性胆管炎外周血单核细胞中的表达 [J]．南方医科大学学报， 2009，29（11）： 21792181．.
28. Chan MC, Chang KM, Chao WC, et al. Evaluation of a new inflammatory molecule (triggering receptor expressed on myeloid cells1) in the diagnosis of pleural effusion [J]. Respirology, 2007, 12(3): 333338.
29. Huang LY, Shi HZ, Liang QL, et al. Expression of soluble triggering receptor expression on myeloid cells1 in pleural effusion [J]. Chin Med J (Engl), 2008, 121(17): 16561661.
30. Luo L, Zhou Q, Chen XJ, et al. Effects of the TREM1 pathway modulation during empyema in rats [J]. Chin Med J (Engl), 2010, 123(12): 15611565.
31. Porfyridis I, Plachouras D, Karagianni V, et al. Diagnostic value of triggering receptor expressed on myeloid cells1 and Creactive protein for patients with lung infiltrates:an observational study [J]. BMC Infect Dis, 2010, 10(1): 286.
32. Oudhuis GJ, Beuving J, Bergmans D, et al. Soluble triggering receptor expressed on myeloid cells1in bronchoalveolar lavage fluid is not predictive for ventilatorassociated pneumonia [J]. Intensive Care Med, 2009, 35(7): 12651270.
33. ElSolh AA, Akinnusi ME, Peter M, et al. Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes [J]. Intensive Care Med, 2008, 34(6): 10121019.
34. Schenk M, Bouchon A, Seibold F, et al. TREM1expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases [J]. J Clin Invest, 2007, 117(10): 30973106.
35. 余文，吴伟，张少辉，等. 急性胰腺炎发病机理的研究进展 [J]. 中国普外基础与临床杂志, 2006, 13(6): 733736.
36. Wang DY, Qin RY, Liu ZR, et al. Expression of TREM1 mRNA in acute pancreatitis [J]. World J Gastroenterol, 2004, 10(18): 27442746.
37. 邵子力，曹良启，彭和平，等．髓样细胞表达触发受体1在重症急性胰腺炎中的表达和意义 [J]．中华普通外科学文献（电子版）， 2010， 4（4）： 328331．.
38. 路筝．髓样细胞表达激发受体1（TREM1）对重症急性胰腺炎继发感染的诊断价值和分子治疗应用 [D]. 第二军医大学, 2008．.
39. Yasuda T, Takeyama Y, Ueda T, et al. Increased levels of soluble triggering receptor expressed on myeloid cells1 in patients with acute pancreatitis [J]. Crit Care Med, 2008, 36(7): 20482053.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Advance of Triggering Receptor Expressed on Myeloid Cells-1

Abstract Full text Figures/Tables Video References Cited by

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