Study on Expressions of Survivin, p53, and Ki67 in Patients with Recurrence or Metastasis Breast Cancer and Their Correlations_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

GUAN Xiaoqing ¹ , WU Ji ¹ , GU Shucheng ¹ , ZHENG Xiangxin ¹ , CHEN Yan ¹ , WU Jianqiang ¹ , SHI Xiaohong ² , JIANG Xiaoling ² , YUAN Mu ¹ , WU Jisheng ¹

1.Department of Breast Surgery, Suqian People’s Hospital of Nanjing DrumTower Hospital Group, Suqian 223800, Jiangsu Province, China;;
2.Department of Pathology, Suqian People’s Hospital of Nanjing DrumTower Hospital Group, Suqian 223800, Jiangsu Province, China;

Corresponding author：

Keywords：

Recurrence and metastasis breast cancer; Survivin; p53; Ki67

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ObjectiveTo explore the expressions of survivin, p53, and Ki67 in recurrence or metastasis breast cancer tissue, and explore their correlations and clinical significance. MethodsEighty-six patients with the chest wall local recurrence, axillary or supraclavicular lymph node metastases get treated in this hospital between January 2005 and January 2010 were excised and the expressions of survivin, p53, and Ki67 were detected by immunohistochemistry test, then compared them between the recurrence and metastasis breast cancer tissues and the primary breast cancer tissues. ResultsThe positive expression rate of survivin, p53, and Ki67 in the recurrence and metastasis breast cancer tissues were significantly higher than those in the primary breast cancer tissues, survivin: 90.70% (78/86) versus 61.63% (53/86), χ2=20.014 895, P lt;0.001; p53: 68.60% (59/86) versus 52.33% (45/86), χ2=4.766 968, P lt;0.05; Ki67: 62.79% (54/86) versus 46.51% (40/86), χ2=4.597 927，P lt;0.05. The positive expression rates of survivin in the recurrence and metastasis patients with p53, Ki67 negative expression were significantly higher than those of the primary breast cancer tissue (70.37% versus 24.39%, χ2=14.071 113, P lt;0.05; 75.00% versus 39.13%, χ2=6.540 373, P lt;0.05). The correlation coefficient of survivin with p53 and Ki67 positive expressions in the recurrence and metastasis breast cancer tissue and the primary breast cancer tissue were 0.876 214, 0.773 643 and 0.725 164, 0.698 112, respectively, P lt;0.05. ConclusionThe positive expression rates of survivin, p53, and Ki67 which increase in recurrence and metastasis breast cancer tissue indicate bad prognosis.

Citation： GUAN Xiaoqing ,WU Ji,GU Shucheng,ZHENG Xiangxin,CHEN Yan,WU Jianqiang,SHI Xiaohong,JIANG Xiaoling,YUAN Mu,WU Jisheng. Study on Expressions of Survivin, p53, and Ki67 in Patients with Recurrence or Metastasis Breast Cancer and Their Correlations. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(3): 290-294. doi: Copy

1.	Ambrosini G, Adida C, Altieri DC. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med, 1997, 3(8): 917921．.
2.	陈曦海, 张岂凡, 马荣. 反义survivin诱导胃癌SGC7901细胞凋亡及逆转耐药的研究 [J]. 中国普外基础与临床杂志, 2007, 14(1): 6367．.
3.	李红, 张敏, 赵瑞霞, 等. 乳腺癌组织中p53和VEGF及NOS的表达及临床意义 [J]. 中国肿瘤临床与康复, 2010, 17(5): 394399.
4.	张子房, 尹江涛, 唐炜. COX2、p53和生成素在镇江地区胃癌患者的表达 [J]. 江苏医药, 2010, 36(18): 21392142．.
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10.	张梅, 张兴义, 邹洪杰, 等．细胞周期蛋白D1、Ki67和bcl2的表达与CD117阳性的胃肠道间质瘤生物学行为的关系 [J]．中华病理学杂志, 2005, 34(12): 788790．.
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12.	冯雯, 曹亦军, 张计训. 甲状腺癌中Ki67和survivin的表达及意义 [J]. 实用医学杂志, 2009, 25(19): 32153218．.
13.	李文竹, 王长胜, 张玉书. 甲状腺癌术后残余癌效果分析 [J]. 实用医学杂志, 2007, 23(6): 841842．.
14.	王合兵, 肖坚, 陈文新． ER、PR、p53及Her2在113例乳腺癌中的表达及临床意义 [J]．肿瘤学杂志, 2010, 16(9): 718720．.
15.	孙浩, 于晓东. Pgp、GSTπ和CerbB2在乳腺癌中的表达及其临床意义 [J]. 中国普外基础与临床杂志, 2009, 16(1): 5659．.
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19.	王玉, 王晋芬. ER、PR、Ki67和P53在乳腺癌中表达的相关分析及临床意义 [J]. 山西医药杂志, 2008, 37(4): 319321.
20.	胡贇宏, 宋和平, 林晓燕, 等. Ki67、P53抗原和nm23蛋白在乳腺癌中的表达及其临床意义 [J]. 中国医药指南, 2008, 6(2): 1416．.
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22.	Tanaka K, Iwamoto S, Gon G, et al. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas [J]. Clin Cancer Res, 2000, 6(1): 127134.
23.	Tan PH, Bay BH, Yip G, et al. Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death [J]. Mod Pathol, 2005, 18(3): 374381．.
24.	孙治君, 周鑫, 姚榛祥, 等. Pgp、nm23和p53联合检测判断乳腺癌预后的价值 [J]. 中国普外基础与临床杂志, 2005, 12(3): 244248．.
25.	陈莉, 杨新华, 杨程, 等. 雌激素受体β1上调p53基因表达促进乳腺癌细胞的凋亡 [J]. 中国普外基础与临床杂志, 2010, 17(2): 161164．.
26.	仲蕾, 张建国, 郭保良, 等. 乳腺癌中Survivin和Ki67的表达及其临床意义 [J]．中国医师进修杂志, 2008, 31(17): 36．.
27.	陈建华, 朱世海, 魏中华, 等. 乳腺癌中生存素表达及其与Caspase3和临床相关因素的关系 [J]. 江苏医药, 2009, 35(1): 4951．.

1. Ambrosini G, Adida C, Altieri DC. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med, 1997, 3(8): 917921．.
2. 陈曦海, 张岂凡, 马荣. 反义survivin诱导胃癌SGC7901细胞凋亡及逆转耐药的研究 [J]. 中国普外基础与临床杂志, 2007, 14(1): 6367．.
3. 李红, 张敏, 赵瑞霞, 等. 乳腺癌组织中p53和VEGF及NOS的表达及临床意义 [J]. 中国肿瘤临床与康复, 2010, 17(5): 394399.
4. 张子房, 尹江涛, 唐炜. COX2、p53和生成素在镇江地区胃癌患者的表达 [J]. 江苏医药, 2010, 36(18): 21392142．.
5. 程广保, 吴璟霞. 乳腺癌发病的基因调控机制 [J]. 现代肿瘤学杂志, 2010, 18(9): 18481852.
6. 王珍珍, 全培良, 徐虹, 等. survivin在非小细胞肺癌中的表达及其与p53的相关性 [J]. 医药论坛杂志, 2010, 31(18): 812.
7. 李梅, 陈芸, 张丽娟, 等. survivin、p53、Ki67在乳腺癌组织中的表达及其意义 [J]. 实用癌症杂志, 2007, 22(2): 154156．.
8. 程虹, 戴林, 郭双平, 等译. 乳腺及女性生殖器官肿瘤病理学和遗传学 [M]. 北京: 人民卫生出版社, 2006: 23.
9. 唐金海. 乳腺肿瘤综合治疗 [M]. 南京: 江苏科学技术出版社, 2008: 207209.
10. 张梅, 张兴义, 邹洪杰, 等．细胞周期蛋白D1、Ki67和bcl2的表达与CD117阳性的胃肠道间质瘤生物学行为的关系 [J]．中华病理学杂志, 2005, 34(12): 788790．.
11. 华立新, 黄桂林, 李豫江. Survivin在乳腺癌中的表达及临床意义 [J]. 国际外科学杂志, 2008, 35(5): 311314．.
12. 冯雯, 曹亦军, 张计训. 甲状腺癌中Ki67和survivin的表达及意义 [J]. 实用医学杂志, 2009, 25(19): 32153218．.
13. 李文竹, 王长胜, 张玉书. 甲状腺癌术后残余癌效果分析 [J]. 实用医学杂志, 2007, 23(6): 841842．.
14. 王合兵, 肖坚, 陈文新． ER、PR、p53及Her2在113例乳腺癌中的表达及临床意义 [J]．肿瘤学杂志, 2010, 16(9): 718720．.
15. 孙浩, 于晓东. Pgp、GSTπ和CerbB2在乳腺癌中的表达及其临床意义 [J]. 中国普外基础与临床杂志, 2009, 16(1): 5659．.
16. Verhagen AM, Ekert PG, Pakusch M, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins [J]. Cell, 2000, 102(1): 4353．.
17. 陈雪松, 赵艳滨, 蔡莉, 等. 血管紧张素Ⅱ受体、p53和Survivin在乳腺癌中的表达及相关性研究 [J]. 现代肿瘤医学, 2008, 16(2): 204207．.
18. Rohan TE, Li SQ, Hartwick R, et al. p53 alterations and protein accumulation in benign breast tissue and breast cancer risk: a cohort study [J]. Cancer Epidemiol Biomarkers Prev, 2006, 15(7): 13161323．.
19. 王玉, 王晋芬. ER、PR、Ki67和P53在乳腺癌中表达的相关分析及临床意义 [J]. 山西医药杂志, 2008, 37(4): 319321.
20. 胡贇宏, 宋和平, 林晓燕, 等. Ki67、P53抗原和nm23蛋白在乳腺癌中的表达及其临床意义 [J]. 中国医药指南, 2008, 6(2): 1416．.
21. Rohayem J, Diestelkoetter P, Weigle B, et al. Antibody response to the tumorassociated inhibitor of apoptosis protein survivin in cancer patients [J]. Cancer Res, 2000, 60(7): 18151817.
22. Tanaka K, Iwamoto S, Gon G, et al. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas [J]. Clin Cancer Res, 2000, 6(1): 127134.
23. Tan PH, Bay BH, Yip G, et al. Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death [J]. Mod Pathol, 2005, 18(3): 374381．.
24. 孙治君, 周鑫, 姚榛祥, 等. Pgp、nm23和p53联合检测判断乳腺癌预后的价值 [J]. 中国普外基础与临床杂志, 2005, 12(3): 244248．.
25. 陈莉, 杨新华, 杨程, 等. 雌激素受体β1上调p53基因表达促进乳腺癌细胞的凋亡 [J]. 中国普外基础与临床杂志, 2010, 17(2): 161164．.
26. 仲蕾, 张建国, 郭保良, 等. 乳腺癌中Survivin和Ki67的表达及其临床意义 [J]．中国医师进修杂志, 2008, 31(17): 36．.
27. 陈建华, 朱世海, 魏中华, 等. 乳腺癌中生存素表达及其与Caspase3和临床相关因素的关系 [J]. 江苏医药, 2009, 35(1): 4951．.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study on Expressions of Survivin, p53, and Ki67 in Patients with Recurrence or Metastasis Breast Cancer and Their Correlations

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