p120-Catenin━━A New Member of Catenin Family_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

NAN Runling ¹ , SHANG Peizhong ²

1.Hebei North University, Zhangjiakou 075000, Hebei Province, China;;
2.Department of General Surgery, The 251st Hospital of PLA, Zhangjiakou 075000, Hebei Province, China;

Corresponding author：

Keywords：

p120-catenin; Cell adhesion; Malignant tumor

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ObjectiveTo summarize the progress of p120-catenin (p120ctn)——a new member of catenin family in tumor research. MethodsDemestic and international published literatures related to p120ctn in recent years were collected and reviewed. Results① p120ctn was involved in formation of cadherincatenin complex, participated in cell growth, proliferation, and adheren junctions. ② p120ctn regulated Rho GTP activity and promoted cell motility. ③ p120ctn was involved in the regulation of gene transcription through binding with the nuclear transcription factor Kaiso. ④ p120ctn was involved in angiogenesis process induced by vascular endothelial growth factor. ⑤ p120ctn was involved in inflammation, cell malignant transformation, and tumor invasion and metastasis. ConclusionsAs a new member of catenin family, p120ctn participates in a variety of biological processes relying on its cellular localization. It will be facilitated to judge the genesis and progression of tumor from the abnormal alteration of p120ctn according to understanding the biological function and mechanism of p120ctn in the molecular level, a new pathway in the prevention and treatment of cancer is provided.

Citation： NAN Runling ,SHANG Peizhong. p120-Catenin━━A New Member of Catenin Family. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(4): 462-467. doi: Copy

1.	Cheung LW, Leung PC, Wong AS. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropinreleasing hormone to promote tumor cell migration and invasion in ovarian cancer [J]. Oncogene, 2010, 29(16): 24272440.
2.	Albert B, Reynolds AB. p120catenin: Past and present [J]. Biochim Biophys Acta, 2007, 1773(1): 27.
3.	欧海玲, 覃宇周, 张锡流. Ecadherin/p120ctn与肿瘤关系的研究进展 [J]. 中国临床新医学, 2009, 2(2): 201205.
4.	Hatzfel DM. The p120 family of cell adhesion molecules [J]. Eur J Cell Biol, 2005, 84(23): 205214.
5.	Grossmann KS, Grund C, Huelsken J, et al. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation [J]. J Cell Biol, 2004, 167(1): 149160.
6.	Ishiyama N, Lee SH, Liu S, et al. Dynamic and static interactions between p120 catenin and Ecadherin regulate the stability of cellcell adhesion [J]. Cell, 2010, 141(1): 117128.
7.	Xiao K, Oas RG, Chiasson CM, et al. Role of p120catenin in cadherin trafficking [J]. Biochim Biophys Acta, 2007, 1773(1): 816.
8.	SmalleyFreed WG, Efimov A, Burnett PE, et al. p120catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [J]. J Clin Invest, 2010, 120(6): 18241835.
9.	Ichii T, Takeichi M. p120catenin regulates microtubule dynamics and cell migration in a cadherinindependent manner [J]. Genes Cells, 2007, 12(7): 827839.
10.	Anastasiadis PZ. p120ctn: A nexus for contextual signaling via Rho GTPases [J]. Biochim Biophys Acta, 2007, 1773(1): 3446.
11.	Kolanus W, Zeitlmann L. Regulation of integrin function by insideout signaling mechanisms [J]. Curr Top Microbiol Immunol, 1998, 231: 3349.
12.	Fukumoto Y, Shintani Y, Reynolds AB, et al. The regulatory or phosphorylation domain of p120 catenin controls Ecadherin dynamics at the plasma membrane [J]. Exp Cell Res, 2008, 314(1): 5267.
13.	Brown MV, Burnett PE, Denning MF, et al. PDGF receptor activation induces p120catenin phosphorylation at serine 879 via a PKCalphadependent pathway [J]. Exp Cell Res, 2009, 315(1): 3949.
14.	Soto E, Yanagisawa M, Marlow LA, et al. p120 catenin induces opposing effects on tumor cell growth depending on Ecadherin expression [J]. J Cell Biol, 2008, 183(4): 737749.
15.	Zhang J, O’Donnell JJ 3rd, Holian O, et al. P120 catenin represses transcriptional activity through Kaiso in endothelial cells [J]. Microvasc Res, 2010, 80(2): 233239.
16.	Fukuyama T, Ogita H, Kawakatsu T, et al. Activation of Rac by cadherin through the cSrcRap1phosphatidylinositol 3kinaseVav2 pathway [J]. Oncogene, 2006, 25(1): 819.
17.	Daniel JM. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso [J]. Biochim Biophys Acta, 2007, 1773(1): 5968.
18.	Park JI, Kim SW, Lyons JP, et al. Kaiso/p120catenin and TCF/betacatenin complexes coordinately regulate canonical Wnt gene targets [J]. Dev Cell, 2005, 8(6): 843854.
19.	Dai SD, Wang Y, Jiang GY, et al. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn [J]. Lung Cancer, 2010, 67(2): 205215.
20.	罗小华, 刘文励. P120ctn在血管内皮生长因子诱导血管生成中的作用 [J]. 临床血液学杂志, 2006, 19(1): 5456.
21.	Oas RG, Xiao K, Summers S, et al. p120Catenin is required for mouse vascular development [J]. Circ Res, 2010, 106(5): 941951.
22.	Esser S, Lampugnani MG, Corada M, et al. Vascular endothelial growth factor induces VEcadherin tyrosine phosphorylation in endothelial cells [J]. J Cell Sci, 1998, 111(Pt 13): 18531865.
23.	van Hengel J, van Roy F. Diverse functions of p120ctn in tumors [J]. Biochim Biophys Acta, 2007, 1773(1): 7888.
24.	黄华艺, 农朝赞, 郭凌宵, 等. 肝癌细胞生物学行为改变涉及p120ctn酪氨酸磷酸化的研究 [J]. 中华医学杂志, 2003, 83(20): 18011806.
25.	Nong CZ, Pan LL, He WS, et al. P120ctn overexpression enhances beta catenin Ecadherin binding and down regulates expression of survivin and cyclin D1 in BEL7404 hepatoma cells [J]. World J Gastroenterol, 2006, 12(8): 11871191.
26.	农朝赞, 黄婵娟, 潘莉莉, 等. β连环蛋白在转染p120ctn同工蛋白3A的肝癌细胞中的表达变化 [J]. 临床与实验病理学杂志, 2008, 24(6): 712715.
27.	Zhai B, Yan HX, Liu SQ, et al. Reduced expression of Ecadherin/catenin complex in hepatocellular carcinomas [J]. World J Gastroenterol, 2008, 14(37): 56655673.
28.	张毅, 朱瑾, 杨占宇, 等. 连环蛋白P120在肝细胞癌中的表达及其意义 [J]. 消化外科, 2006, 5(6): 431434.
29.	Karatzas G, Karayiannakis AJ, Syrigos KN, et al. Expression patterns of the Ecadherincatenin cellcell adhesion complex in gastric cancer [J]. Hepatogastroenterology, 2000, 47(35): 14651469.
30.	Ogden SR, Wroblewski LE, Weydig C, et al. p120 and Kaiso regulate Helicobacter pyloriinduced expression of matrix metalloproteinase [J]. Mol Biol Cell, 2008,19(10): 41104121.
31.	Jawhari AU, Noda M, Pignatelli M, et al. Upregulated cytoplasmic expression, with reduced membranous distribution, of the srcsubstrate p120 (ctn) in gastric carcinoma [J]. J Pathol, 1999, 189(2): 180185.
32.	虞志强. CDX2和p120catenin在胃癌组织中的临床意义 [J]. 实用癌症杂志, 2009, 24(6): 573575.
33.	Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer [J]. Biochim Biophys Acta, 2003, 1653(1): 124.
34.	戴越盟, 严律南. β连环蛋白及APC基因与肿瘤 [J]. 中国普外基础与临床杂志, 2002, 9(4): 291292.
35.	Yanagisawa M, Huveldt D, Kreinest P, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease [J]. J Biol Chem, 2008, 283(26): 1834418354.
36.	李景南, 李潇, 钱家鸣, 等. Kras基因突变通过调节Ecadherin/βcatenin/p120蛋白复合体形成和RhoA蛋白活性对结肠癌细胞株Caco2转移的影响 [J]. 中国医学科学院学报, 2010, 32(1): 4650.
37.	Bellovin DI, Bates RC, Muzikansky A, et al. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease [J]. Cancer Res, 2005, 65(23): 1093810945.
38.	Verschuur EM, Siersema PD. Diagnostics and treatment of esophageal cancers [J]. Ned Tijdschr Tandheelkd, 2010, 117(9): 427431.
39.	Ma J, Zhang J, Ma Y, et al. Adenovirusmediated RhoA shRNA suppresses growth of esophageal squamous cell carcinoma cells in vitro and in vivo [J]. Med Oncol, 2010, [Epub ahead of print].
40.	Chung Y, Lam AK, Luk JM, et al. Altered Ecadherin expression and p120 catenin localization in esophageal squamous cell carcinoma [J]. Ann Surg Oncol, 2007, 14(11): 32603267.
41.	Wijnhoven BP, Pignatelli M, Dinjens WN, et al. Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction [J]. J Surg Oncol, 2005, 92(2): 116123.
42.	Miao Y, Liu N, Zhang Y, et al. p120ctn isoform 1 expression significantly correlates with abnormal expression of Ecadherin and poor survival of lung cancer patients [J]. Med Oncol, 2010, 27(3): 880886.
43.	Dai SD, Zhang XW, Qi FJ, et al. Expression of Ecadherin, betacatenin and p120ctn in the pulmonary sclerosing hemangioma [J]. Lung Cancer, 2007, 57(1): 5459.
44.	Wang EH, Liu Y, Xu HT, et al. Abnormal expression and clinicopathologic significance of p120catenin in lung cancer [J]. Histol Histopathol, 2006, 21(8): 841847.
45.	Liu Y, Wang Y, Zhang Y, et al. Abnormal expression of p120catenin, Ecadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer [J]. Lung Cancer, 2009, 63(3): 375382.
46.	苗原, 刘洋, 王妍, 等. p120ctn亚型在肺鳞癌、腺癌中表达及意义 [J]. 中国肺癌杂志, 2008, 11(2): 189193.
47.	Chu EA, Wu JM, Tunkel DE, et al. Nasopharyngeal carcinoma: the role of the EpsteinBarr virus [J]. Medscape J Med, 2008, 10(7): 165.
48.	Dittmer DP, Hilscher CJ, Gulley ML, et al. Multiple pathways for EpsteinBarr virus episome loss from nasopharyngeal carcinoma [J]. Int J Cancer, 2008, 123(9): 21052112.
49.	游淑源, 韩安家, 张芬芬, 等. 鼻咽癌中EB病毒编码的潜伏膜蛋白1对βcatenin转录活性及表达的影响 [J]. 中华病理学杂志, 2010, 39(8): 537541.
50.	叶辉信, 张锡流, 欧海燕, 等. 上皮钙黏蛋白和连环蛋白120在鼻咽癌组织中的表达及相关性研究 [J]. 临床耳鼻咽喉头颈外科杂志, 2009, 23(14): 646648.
51.	欧海玲, 覃宇周, 张锡流, 等. P120连环蛋白在鼻咽癌中的表达及其与细胞凋亡的关系 [J]. 实用医学杂志, 2009, 25(22): 37493752.
52.	Zhang X, Disanto ME. Rhokinase, a common final path of various contractile bladder and ureter stimuli [J]. Handb Exp Pharmacol, 2011, (202): 543568.
53.	Mandeville JA, Silva Neto B, Vanni AJ, et al. Pcadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells [J]. BJU Int, 2008, 2(11): 17071714.
54.	林成楚, 许恩赐. 膀胱移行细胞癌中p120ctn的表达及意义 [J]. 山东医药, 2008, 48(30): 3637.
55.	Silva Neto B, Smith GL, Mandeville JA, et al. Prognostic significance of altered p120 ctn expression in bladder cancer [J]. BJU Int, 2008, 101(6): 746752.
56.	张锡流, 何仕远, 张力, 等． E钙黏附蛋白及其相关蛋白在前列腺癌组织中的表达及其临床意义 [J]. 检验医学, 2006, 21(1): 57.
57.	Kaulfuss S, von Hardenberg S, Schweyer S, et al. Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression [J]. Oncogene, 2009, 28(45): 39713982.
58.	van Oort IM, Tomita K, van Bokhoven A, et al. The prognostic value of Ecadherin and the cadherinassociated molecules alpha, beta, gammacatenin and p120ctn in prostate cancer specific survival: a longterm followup study [J]. Prostate, 2007, 67(13): 14321438.
59.	Kallakury BV, Sheehan CE, WinnDeen E, et al. Decreased expression of catenins (alpha and beta), p120 CTN, and Ecadherin cell adhesion proteins and Ecadherin gene promoter methylation in prostatic adenocarcinomas [J]. Cancer, 2001, 92(11): 27862795.
60.	Freeman JW, McGrath P, Bondada V, et al. Prognostic significance of proliferation associated nucleolar antigen p120 in human breast carcinoma [J].Cancer Res, 1991, 51(8): 19731978.
61.	Paredes J, Correia AL, Ribeiro AS, et al. Expression of p120catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines [J]. Cell Oncol, 2007, 29(6): 467476.
62.	Sarrió D, PérezMies B, Hardisson D, et al. Cytoplasmic localization of p120ctn and Ecadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions [J]. Oncogene, 2004, 23(19): 32723283.
63.	Dabbs DJ, Bhargava R, Chivukula M. Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin [J]. Am J Surg Pathol, 2007, 31(3): 427437.
64.	李晓鸣, 温漓潮, 朱任之. 乳腺典型髓样癌与非典型髓样癌生物学行为差异的研究 [J]. 中国普外基础与临床杂志, 2003, 10(3): 268269.
65.	Boriani S, Bandiera S, Biagini R, et al. Chordoma of the mobilesp ine: fifty years of experience [J]. Spine (Phila Pa 1976), 2006, 31(4): 493503.
66.	Guirat A, Affes N, Boujlbene S, et al. Sacral chordoma: a rare tumor of the buttocks [J]. Ann Dermatol Venereol, 2009, 136(67): 526529.
67.	Schwab JH, Boland PJ, Agaram NP, et al. Chordoma and chondrosarcoma gene profile: implications for immunotherapy [J]. Cancer Immunol Immunother, 2009, 58(3): 339349.
68.	马俊明, 杨兴海, 黄权, 等. Ecadherin和P120ctn在脊柱脊索瘤中的异常表达 [J]. 脊柱外科杂志, 2009, 7(4): 193197.
69.	Chartier NT, Oddou CI, Lainé MG, et al. Cyclindependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)dependent cell growth control: a new role for p120ctn in cancer [J]. Cancer Res, 2007, 67(20): 97819790.

1. Cheung LW, Leung PC, Wong AS. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropinreleasing hormone to promote tumor cell migration and invasion in ovarian cancer [J]. Oncogene, 2010, 29(16): 24272440.
2. Albert B, Reynolds AB. p120catenin: Past and present [J]. Biochim Biophys Acta, 2007, 1773(1): 27.
3. 欧海玲, 覃宇周, 张锡流. Ecadherin/p120ctn与肿瘤关系的研究进展 [J]. 中国临床新医学, 2009, 2(2): 201205.
4. Hatzfel DM. The p120 family of cell adhesion molecules [J]. Eur J Cell Biol, 2005, 84(23): 205214.
5. Grossmann KS, Grund C, Huelsken J, et al. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation [J]. J Cell Biol, 2004, 167(1): 149160.
6. Ishiyama N, Lee SH, Liu S, et al. Dynamic and static interactions between p120 catenin and Ecadherin regulate the stability of cellcell adhesion [J]. Cell, 2010, 141(1): 117128.
7. Xiao K, Oas RG, Chiasson CM, et al. Role of p120catenin in cadherin trafficking [J]. Biochim Biophys Acta, 2007, 1773(1): 816.
8. SmalleyFreed WG, Efimov A, Burnett PE, et al. p120catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [J]. J Clin Invest, 2010, 120(6): 18241835.
9. Ichii T, Takeichi M. p120catenin regulates microtubule dynamics and cell migration in a cadherinindependent manner [J]. Genes Cells, 2007, 12(7): 827839.
10. Anastasiadis PZ. p120ctn: A nexus for contextual signaling via Rho GTPases [J]. Biochim Biophys Acta, 2007, 1773(1): 3446.
11. Kolanus W, Zeitlmann L. Regulation of integrin function by insideout signaling mechanisms [J]. Curr Top Microbiol Immunol, 1998, 231: 3349.
12. Fukumoto Y, Shintani Y, Reynolds AB, et al. The regulatory or phosphorylation domain of p120 catenin controls Ecadherin dynamics at the plasma membrane [J]. Exp Cell Res, 2008, 314(1): 5267.
13. Brown MV, Burnett PE, Denning MF, et al. PDGF receptor activation induces p120catenin phosphorylation at serine 879 via a PKCalphadependent pathway [J]. Exp Cell Res, 2009, 315(1): 3949.
14. Soto E, Yanagisawa M, Marlow LA, et al. p120 catenin induces opposing effects on tumor cell growth depending on Ecadherin expression [J]. J Cell Biol, 2008, 183(4): 737749.
15. Zhang J, O’Donnell JJ 3rd, Holian O, et al. P120 catenin represses transcriptional activity through Kaiso in endothelial cells [J]. Microvasc Res, 2010, 80(2): 233239.
16. Fukuyama T, Ogita H, Kawakatsu T, et al. Activation of Rac by cadherin through the cSrcRap1phosphatidylinositol 3kinaseVav2 pathway [J]. Oncogene, 2006, 25(1): 819.
17. Daniel JM. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso [J]. Biochim Biophys Acta, 2007, 1773(1): 5968.
18. Park JI, Kim SW, Lyons JP, et al. Kaiso/p120catenin and TCF/betacatenin complexes coordinately regulate canonical Wnt gene targets [J]. Dev Cell, 2005, 8(6): 843854.
19. Dai SD, Wang Y, Jiang GY, et al. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn [J]. Lung Cancer, 2010, 67(2): 205215.
20. 罗小华, 刘文励. P120ctn在血管内皮生长因子诱导血管生成中的作用 [J]. 临床血液学杂志, 2006, 19(1): 5456.
21. Oas RG, Xiao K, Summers S, et al. p120Catenin is required for mouse vascular development [J]. Circ Res, 2010, 106(5): 941951.
22. Esser S, Lampugnani MG, Corada M, et al. Vascular endothelial growth factor induces VEcadherin tyrosine phosphorylation in endothelial cells [J]. J Cell Sci, 1998, 111(Pt 13): 18531865.
23. van Hengel J, van Roy F. Diverse functions of p120ctn in tumors [J]. Biochim Biophys Acta, 2007, 1773(1): 7888.
24. 黄华艺, 农朝赞, 郭凌宵, 等. 肝癌细胞生物学行为改变涉及p120ctn酪氨酸磷酸化的研究 [J]. 中华医学杂志, 2003, 83(20): 18011806.
25. Nong CZ, Pan LL, He WS, et al. P120ctn overexpression enhances beta catenin Ecadherin binding and down regulates expression of survivin and cyclin D1 in BEL7404 hepatoma cells [J]. World J Gastroenterol, 2006, 12(8): 11871191.
26. 农朝赞, 黄婵娟, 潘莉莉, 等. β连环蛋白在转染p120ctn同工蛋白3A的肝癌细胞中的表达变化 [J]. 临床与实验病理学杂志, 2008, 24(6): 712715.
27. Zhai B, Yan HX, Liu SQ, et al. Reduced expression of Ecadherin/catenin complex in hepatocellular carcinomas [J]. World J Gastroenterol, 2008, 14(37): 56655673.
28. 张毅, 朱瑾, 杨占宇, 等. 连环蛋白P120在肝细胞癌中的表达及其意义 [J]. 消化外科, 2006, 5(6): 431434.
29. Karatzas G, Karayiannakis AJ, Syrigos KN, et al. Expression patterns of the Ecadherincatenin cellcell adhesion complex in gastric cancer [J]. Hepatogastroenterology, 2000, 47(35): 14651469.
30. Ogden SR, Wroblewski LE, Weydig C, et al. p120 and Kaiso regulate Helicobacter pyloriinduced expression of matrix metalloproteinase [J]. Mol Biol Cell, 2008,19(10): 41104121.
31. Jawhari AU, Noda M, Pignatelli M, et al. Upregulated cytoplasmic expression, with reduced membranous distribution, of the srcsubstrate p120 (ctn) in gastric carcinoma [J]. J Pathol, 1999, 189(2): 180185.
32. 虞志强. CDX2和p120catenin在胃癌组织中的临床意义 [J]. 实用癌症杂志, 2009, 24(6): 573575.
33. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer [J]. Biochim Biophys Acta, 2003, 1653(1): 124.
34. 戴越盟, 严律南. β连环蛋白及APC基因与肿瘤 [J]. 中国普外基础与临床杂志, 2002, 9(4): 291292.
35. Yanagisawa M, Huveldt D, Kreinest P, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease [J]. J Biol Chem, 2008, 283(26): 1834418354.
36. 李景南, 李潇, 钱家鸣, 等. Kras基因突变通过调节Ecadherin/βcatenin/p120蛋白复合体形成和RhoA蛋白活性对结肠癌细胞株Caco2转移的影响 [J]. 中国医学科学院学报, 2010, 32(1): 4650.
37. Bellovin DI, Bates RC, Muzikansky A, et al. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease [J]. Cancer Res, 2005, 65(23): 1093810945.
38. Verschuur EM, Siersema PD. Diagnostics and treatment of esophageal cancers [J]. Ned Tijdschr Tandheelkd, 2010, 117(9): 427431.
39. Ma J, Zhang J, Ma Y, et al. Adenovirusmediated RhoA shRNA suppresses growth of esophageal squamous cell carcinoma cells in vitro and in vivo [J]. Med Oncol, 2010, [Epub ahead of print].
40. Chung Y, Lam AK, Luk JM, et al. Altered Ecadherin expression and p120 catenin localization in esophageal squamous cell carcinoma [J]. Ann Surg Oncol, 2007, 14(11): 32603267.
41. Wijnhoven BP, Pignatelli M, Dinjens WN, et al. Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction [J]. J Surg Oncol, 2005, 92(2): 116123.
42. Miao Y, Liu N, Zhang Y, et al. p120ctn isoform 1 expression significantly correlates with abnormal expression of Ecadherin and poor survival of lung cancer patients [J]. Med Oncol, 2010, 27(3): 880886.
43. Dai SD, Zhang XW, Qi FJ, et al. Expression of Ecadherin, betacatenin and p120ctn in the pulmonary sclerosing hemangioma [J]. Lung Cancer, 2007, 57(1): 5459.
44. Wang EH, Liu Y, Xu HT, et al. Abnormal expression and clinicopathologic significance of p120catenin in lung cancer [J]. Histol Histopathol, 2006, 21(8): 841847.
45. Liu Y, Wang Y, Zhang Y, et al. Abnormal expression of p120catenin, Ecadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer [J]. Lung Cancer, 2009, 63(3): 375382.
46. 苗原, 刘洋, 王妍, 等. p120ctn亚型在肺鳞癌、腺癌中表达及意义 [J]. 中国肺癌杂志, 2008, 11(2): 189193.
47. Chu EA, Wu JM, Tunkel DE, et al. Nasopharyngeal carcinoma: the role of the EpsteinBarr virus [J]. Medscape J Med, 2008, 10(7): 165.
48. Dittmer DP, Hilscher CJ, Gulley ML, et al. Multiple pathways for EpsteinBarr virus episome loss from nasopharyngeal carcinoma [J]. Int J Cancer, 2008, 123(9): 21052112.
49. 游淑源, 韩安家, 张芬芬, 等. 鼻咽癌中EB病毒编码的潜伏膜蛋白1对βcatenin转录活性及表达的影响 [J]. 中华病理学杂志, 2010, 39(8): 537541.
50. 叶辉信, 张锡流, 欧海燕, 等. 上皮钙黏蛋白和连环蛋白120在鼻咽癌组织中的表达及相关性研究 [J]. 临床耳鼻咽喉头颈外科杂志, 2009, 23(14): 646648.
51. 欧海玲, 覃宇周, 张锡流, 等. P120连环蛋白在鼻咽癌中的表达及其与细胞凋亡的关系 [J]. 实用医学杂志, 2009, 25(22): 37493752.
52. Zhang X, Disanto ME. Rhokinase, a common final path of various contractile bladder and ureter stimuli [J]. Handb Exp Pharmacol, 2011, (202): 543568.
53. Mandeville JA, Silva Neto B, Vanni AJ, et al. Pcadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells [J]. BJU Int, 2008, 2(11): 17071714.
54. 林成楚, 许恩赐. 膀胱移行细胞癌中p120ctn的表达及意义 [J]. 山东医药, 2008, 48(30): 3637.
55. Silva Neto B, Smith GL, Mandeville JA, et al. Prognostic significance of altered p120 ctn expression in bladder cancer [J]. BJU Int, 2008, 101(6): 746752.
56. 张锡流, 何仕远, 张力, 等． E钙黏附蛋白及其相关蛋白在前列腺癌组织中的表达及其临床意义 [J]. 检验医学, 2006, 21(1): 57.
57. Kaulfuss S, von Hardenberg S, Schweyer S, et al. Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression [J]. Oncogene, 2009, 28(45): 39713982.
58. van Oort IM, Tomita K, van Bokhoven A, et al. The prognostic value of Ecadherin and the cadherinassociated molecules alpha, beta, gammacatenin and p120ctn in prostate cancer specific survival: a longterm followup study [J]. Prostate, 2007, 67(13): 14321438.
59. Kallakury BV, Sheehan CE, WinnDeen E, et al. Decreased expression of catenins (alpha and beta), p120 CTN, and Ecadherin cell adhesion proteins and Ecadherin gene promoter methylation in prostatic adenocarcinomas [J]. Cancer, 2001, 92(11): 27862795.
60. Freeman JW, McGrath P, Bondada V, et al. Prognostic significance of proliferation associated nucleolar antigen p120 in human breast carcinoma [J].Cancer Res, 1991, 51(8): 19731978.
61. Paredes J, Correia AL, Ribeiro AS, et al. Expression of p120catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines [J]. Cell Oncol, 2007, 29(6): 467476.
62. Sarrió D, PérezMies B, Hardisson D, et al. Cytoplasmic localization of p120ctn and Ecadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions [J]. Oncogene, 2004, 23(19): 32723283.
63. Dabbs DJ, Bhargava R, Chivukula M. Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin [J]. Am J Surg Pathol, 2007, 31(3): 427437.
64. 李晓鸣, 温漓潮, 朱任之. 乳腺典型髓样癌与非典型髓样癌生物学行为差异的研究 [J]. 中国普外基础与临床杂志, 2003, 10(3): 268269.
65. Boriani S, Bandiera S, Biagini R, et al. Chordoma of the mobilesp ine: fifty years of experience [J]. Spine (Phila Pa 1976), 2006, 31(4): 493503.
66. Guirat A, Affes N, Boujlbene S, et al. Sacral chordoma: a rare tumor of the buttocks [J]. Ann Dermatol Venereol, 2009, 136(67): 526529.
67. Schwab JH, Boland PJ, Agaram NP, et al. Chordoma and chondrosarcoma gene profile: implications for immunotherapy [J]. Cancer Immunol Immunother, 2009, 58(3): 339349.
68. 马俊明, 杨兴海, 黄权, 等. Ecadherin和P120ctn在脊柱脊索瘤中的异常表达 [J]. 脊柱外科杂志, 2009, 7(4): 193197.
69. Chartier NT, Oddou CI, Lainé MG, et al. Cyclindependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)dependent cell growth control: a new role for p120ctn in cancer [J]. Cancer Res, 2007, 67(20): 97819790.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

p120-Catenin━━A New Member of Catenin Family

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