Effect of Modified Sleeve Gastrectomy on Ghrelin and Glucagon Like Peptide-1 in Rats with Diet Induced Obesity_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YAN Lingling , ZHU Zhanyong , WU Dan , WU Yiping.

Department of Cosmetic and Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China;

Corresponding author：

Keywords：

Modified sleeve gastrectomy; High-fat diet induced obesity rat; Growth hormone releasing peptide ghrelin; Glucagon like peptide-1

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ObjectiveTo explore a surgery of effective weight loss concentrating on gut hormone release. MethodsWistar rats were fed with high-fat diet for inducing obesity and which randomly divided into sleeve gastrectomy plus decent jejunoileal bypass (SJB) group (n=12), sleeve gastrectomy (SG) group (n=12), and sham operation (SO) group (n=11), the body weight reduction, food intake, plasma ghrelin level, and glucagon like peptide-1 (GLP-1) level were compared among three groups. ResultsThere were no differences of the body weight and food intake before operation among three groups (P gt;0.05). Compared with the SO group, the body weight descended and the food intake decreased obviously on 1-8 weeks after operation in the SJB group (P lt;0.05), the body weight of rats on 1-8 weeks after operation in the SJB group significantly descended as compared with the SG group (P lt;0.05), and the food intake of rats on week 3, 6, 7, and 8 in the SJB group signicantly decreased as compared with the SG group (P lt;0.05). There were no differences of the levels of the plasma ghrelin and GLP-1 before operation among three groups (P gt;0.05). Compared with SO group, the plasma ghrelin level decreased and the GLP-1 level increased in the SJB group and the SG group, meanwhile the SJB group significantly decreased level of plasma ghrelin and elevated level of plasma GLP-1 as compared with the SG group on week 8 after operation(P lt;0.05). ConclusionThe data demonstrate that SJB could represent an effective way of losing weight by interfering with food intake and obesity related hormone levels.

Citation： YAN Lingling,ZHU Zhanyong,WU Dan,WU Yiping.. Effect of Modified Sleeve Gastrectomy on Ghrelin and Glucagon Like Peptide-1 in Rats with Diet Induced Obesity. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(5): 498-502. doi: Copy

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6.	Hearnshaw C, Matyka K. Managing childhood obesity: when lifestyle change is not enough [J]. Diabetes Obes Metab, 2010, 12(11): 947957.
7.	Chang CY, Huang CK, Chang YY, et al. Prospective study of healthrelated quality of life after RouxenY bypass surgery for morbid obesity [J]. Br J Surg, 2010, 97(10): 15411546.
8.	Hüttl TP, Jauch KW. Surgical therapy of morbid obesity [J]. MMW Fortschr Med, 2010, 152(22): 3235.
9.	Cottam D, Qureshi FG, Mattar SG, et al. Laparoscopic sleeve gastrectomy as an initial weightloss procedure for highrisk patients with morbid obesity [J]. Surg Endosc, 2006, 20(6): 859863.
10.	Kodama Y, Zhao CM, Kulseng B, et al. Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch [J]. J Gastrointest Surg, 2010, 14(10): 15021510.
11.	Rice RD, Simon TE, Seery JM, et al. Laparoscopic sleeve gastrectomy: outcomes at a military training center [J]. Am Surg, 2010, 76(8): 835840.
12.	Himpens J, Dobbeleir J, Peeters G. Longterm results of laparoscopic sleeve gastrectomy for obesity [J]. Ann Surg, 2010, 252(2): 319324.
13.	Langer FB, Bohdjalian A, ShakeriLeidenmühler S, et al. Conversion from sleeve gastrectomy to RouxenY gastric bypassindications and outcome [J]. Obes Surg, 2010, 20(7): 835840.
14.	Suzuki K, Simpson KA, Minnion JS. The role of gut hormones and the hypothalamus in appetite regulation [J]. Endocr J, 2010, 57(5): 359372.
15.	Maljaars J, Romeyn EA, Haddeman E, et al. Effect of fat saturation on satiety, hormone release, and food intake [J]. Am J Clin Nutr, 2009, 89(4): 10191024.
16.	邓治洲, 王烈, 林忆阳, 等. 胃转流术对非肥胖型2型糖尿病的疗效观察及其对胰高血糖素样肽1的影响 [J]. 中国普外基础与临床杂志, 2009, 16(6): 466469.
17.	Shin AC, Zheng H, Townsend RL, et al. Mealinduced hormone responses in a rat model of RouxenY gastric bypass surgery [J]. Endocrinology, 2010, 151(4): 15881597.
18.	Laferrère B. Effect of gastric bypass surgery on the incretins [J]. Diabetes Metab, 2009, 35(6 Pt 2): 513517.
19.	Bueter M, Ashrafian H, le Roux CW. Mechanisms of weight loss after gastric bypass and gastric banding [J]. Obes Facts, 2009, 2(5): 325331.
20.	Ursavas A, Ilcol YO, Nalci N, et al. Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity [J]. Ann Thorac Med, 2010, 5(3): 161165.
21.	Aguirre V, Stylopoulos N, Grinbaum R, et al. An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with dietinduced obesity [J]. Obesity, 2008, 16(12): 25852592.
22.	AbuJaish W, Rosenthal RJ. Sleeve gastrectomy: a new surgical approach for morbid obesity [J]. Expert Rev Gastroenterol Hepatol, 2010, 4(1): 101119.
23.	Brethauer SA, Hammel JP, Schauer PR. Systematic review of sleeve gastrectomy as staging and primary bariatric procedure [J]. Surg Obes Relat Dis, 2009, 5(4): 469475.
24.	Nowak A, Bojanowska E. Effects of peripheral or central GLP1 receptor blockade on leptininduced suppression of appetite [J]. J Physiol Pharmacol, 2008, 59(3): 501510.
25.	Iannelli A, Dainese R, Piche T, et al. Laparoscopic sleeve gastrectomy for morbid obesity [J]. World J Gastroenterol, 2008, 14(6): 821827.

1. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after dietinduced weight loss or gastric bypass surgery [J]. N Engl J Med, 2002, 346(21): 16231630.
2. Samer G, Mattar MD. Lifting the unbearable weight of morbid obesity [J]. Ann Surg, 2008, 247(1): 2829.
3. 张洪义. 外科手术治疗病态性肥胖症的现代进展 [J]. 空军总医院学报, 2006, 22(3): 165167.
4. Safer DJ. Diet, behavior modification, and exercise: a review of obesity treatments from a longterm perspective [J]. South Med J, 1991, 84(12): 14701474.
5. Clark A, Franklin J, Pratt I, et al. Overweight and obesity-use of portion control in management [J]. Aust Fam Physician, 2010, 39(6): 407411.
6. Hearnshaw C, Matyka K. Managing childhood obesity: when lifestyle change is not enough [J]. Diabetes Obes Metab, 2010, 12(11): 947957.
7. Chang CY, Huang CK, Chang YY, et al. Prospective study of healthrelated quality of life after RouxenY bypass surgery for morbid obesity [J]. Br J Surg, 2010, 97(10): 15411546.
8. Hüttl TP, Jauch KW. Surgical therapy of morbid obesity [J]. MMW Fortschr Med, 2010, 152(22): 3235.
9. Cottam D, Qureshi FG, Mattar SG, et al. Laparoscopic sleeve gastrectomy as an initial weightloss procedure for highrisk patients with morbid obesity [J]. Surg Endosc, 2006, 20(6): 859863.
10. Kodama Y, Zhao CM, Kulseng B, et al. Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch [J]. J Gastrointest Surg, 2010, 14(10): 15021510.
11. Rice RD, Simon TE, Seery JM, et al. Laparoscopic sleeve gastrectomy: outcomes at a military training center [J]. Am Surg, 2010, 76(8): 835840.
12. Himpens J, Dobbeleir J, Peeters G. Longterm results of laparoscopic sleeve gastrectomy for obesity [J]. Ann Surg, 2010, 252(2): 319324.
13. Langer FB, Bohdjalian A, ShakeriLeidenmühler S, et al. Conversion from sleeve gastrectomy to RouxenY gastric bypassindications and outcome [J]. Obes Surg, 2010, 20(7): 835840.
14. Suzuki K, Simpson KA, Minnion JS. The role of gut hormones and the hypothalamus in appetite regulation [J]. Endocr J, 2010, 57(5): 359372.
15. Maljaars J, Romeyn EA, Haddeman E, et al. Effect of fat saturation on satiety, hormone release, and food intake [J]. Am J Clin Nutr, 2009, 89(4): 10191024.
16. 邓治洲, 王烈, 林忆阳, 等. 胃转流术对非肥胖型2型糖尿病的疗效观察及其对胰高血糖素样肽1的影响 [J]. 中国普外基础与临床杂志, 2009, 16(6): 466469.
17. Shin AC, Zheng H, Townsend RL, et al. Mealinduced hormone responses in a rat model of RouxenY gastric bypass surgery [J]. Endocrinology, 2010, 151(4): 15881597.
18. Laferrère B. Effect of gastric bypass surgery on the incretins [J]. Diabetes Metab, 2009, 35(6 Pt 2): 513517.
19. Bueter M, Ashrafian H, le Roux CW. Mechanisms of weight loss after gastric bypass and gastric banding [J]. Obes Facts, 2009, 2(5): 325331.
20. Ursavas A, Ilcol YO, Nalci N, et al. Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity [J]. Ann Thorac Med, 2010, 5(3): 161165.
21. Aguirre V, Stylopoulos N, Grinbaum R, et al. An endoluminal sleeve induces substantial weight loss and normalizes glucose homeostasis in rats with dietinduced obesity [J]. Obesity, 2008, 16(12): 25852592.
22. AbuJaish W, Rosenthal RJ. Sleeve gastrectomy: a new surgical approach for morbid obesity [J]. Expert Rev Gastroenterol Hepatol, 2010, 4(1): 101119.
23. Brethauer SA, Hammel JP, Schauer PR. Systematic review of sleeve gastrectomy as staging and primary bariatric procedure [J]. Surg Obes Relat Dis, 2009, 5(4): 469475.
24. Nowak A, Bojanowska E. Effects of peripheral or central GLP1 receptor blockade on leptininduced suppression of appetite [J]. J Physiol Pharmacol, 2008, 59(3): 501510.
25. Iannelli A, Dainese R, Piche T, et al. Laparoscopic sleeve gastrectomy for morbid obesity [J]. World J Gastroenterol, 2008, 14(6): 821827.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Modified Sleeve Gastrectomy on Ghrelin and Glucagon Like Peptide-1 in Rats with Diet Induced Obesity

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