Quality of Life after Sentinel Lymph Node Biopsy in Patients with Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Chunying , JI Wei , SUN Xiao , CHEN Peng , WANG Yongsheng.

Breast Cancer Center, Shandong Cancer Hospital, Jinan 250117, Shandong Province, China;

Corresponding author：

Keywords：

Breast cancer; Sentinel lymph node biopsy; Quality of life

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo evaluate the quality of life after sentinel lymph node biopsy (SLNB) in patients with breast cancer. MethodsFrom January 2004 to December 2006, 591 patients with breast cancer who were suitable for SLNB were divided into SLNB group (n=339) and axillary lymph node dissection (ALND) group (n=252). All patients didn’t have the upper extremity joints disease, the vascular nerve disease, and the cervical spondylosis previously. Results①In patients with SLNB, the circumferences of upper arm in one, two, and three weeks after operation were similar to those before operation (P=0.232, P=0.318, and P=0.415, respectively). While, in patients with ALND, the circumferences of upper arm in one or two weeks after operation were significantly bigger than those before operation (P=0.011, P=0.041, respectively), and the circumference in three weeks after operation was similar to that before operation (P=0.290). ②In patients with SLNB, the outreach angles of shoulder joint in one and two weeks after operation were significantly smaller than those before operation (P=0.031, P=0.043, respectively), and the angle in three weeks after operation was similar to that before operation (P=0.196). However, in patients with ALND, the angles in one, two or three weeks after operation were significantly smaller than those before operation (all P lt;0.001). ③The retention time of drainage tube in patients with ALND who received breast conserving surgery or mastectomy was significantly longer than that in patients with SLNB who received mastectomy (all P lt;0.001). ④The infection rate and the sensory disjunction rate in patients with ALND were significantly higher than those in patients with SLNB (P=0.002, P lt;0.001, respectively). ConclusionsFor patients with lymph node negative breast cancer, SLNB could decrease postoperative complications, and improve the quality of life. It could also save money by reducing hospital stay.

Citation： WANG Chunying,JI Wei,SUN Xiao,CHEN Peng,WANG Yongsheng.. Quality of Life after Sentinel Lymph Node Biopsy in Patients with Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(9): 922-925. doi: Copy

1.	王永胜. 乳腺癌前哨淋巴结活检: 共识与展望 [J]. 中国普外基础与临床杂志, 2009, 16(7): 505509.
2.	王永胜. 乳腺癌前哨淋巴结的研究进展 [J]. 中国普外基础与临床杂志, 2005, 12(3): 212215.
3.	孙晓, 王永胜. 乳腺癌前哨淋巴结转移的诊断与预后 [J]. 中国肿瘤外科杂志, 2009, 1(4): 228232.
4.	Goldhirsch A, Ingle JN, Gelber RD, et al. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009 [J]. Ann Oncol, 2009, 20(8): 13191329.
5.	Warmuth MA, Bowen G, Prosnitz LR, et al. Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey [J]. Cancer, 1998, 83(7): 13621368.
6.	Fleissig A, Fallowfield LJ, Langridge CI, et al. Postoperative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer [J]. Breast Cancer Res Treat, 2006, 95(3): 279293.
7.	Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinelnode biopsy with routine axillary dissection in breast cancer [J]. N Engl J Med, 2003, 349(6): 546553.
8.	Julian TB, Krag D, Brown A, et al. Preliminary technical results of NSAPBP B32, a randomized phase Ⅲ clinical trial to compare sentinel node resection to conventional axillary dissection in clinically nodenegative breast cancer patients [J]. Breast Cancer Res Treat, 2004, 88(S1): S11S12.
9.	王永胜, 欧阳涛, 王启堂, 等. 中国前哨淋巴结活检多中心协作研究CBCSG001最新资料报告 [J]. 中华乳腺病杂志(电子版), 2009, 3(3): 265272.
10.	王永胜, 左文述, 刘娟娟, 等. 乳腺癌前哨淋巴结活检替代腋窝清扫术前瞻性非随机对照临床研究 [J]. 外科理论与实践, 2006, 11(2): 104107.
11.	Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer:the almanac trial [J]. J Natl Cancer Inst, 2006, 98(9): 599609.
12.	Purushotham AD, Upponi S, Klevesath MB, et al. Morbidity after sentinel lymph node biopsy in primary breast cancer:results from a randomized controlled trial [J]. J Clin Oncol, 2005, 23(19): 43124321.
13.	Schulze T, Mucke J, Markwardt J, et al. Longterm morbidity of patients with early breast cancer after sentinel lymph node biopsy compared to axillary lymph node dissection [J]. J Surg Oncol, 2006, 93(2): 109119.

1. 王永胜. 乳腺癌前哨淋巴结活检: 共识与展望 [J]. 中国普外基础与临床杂志, 2009, 16(7): 505509.
2. 王永胜. 乳腺癌前哨淋巴结的研究进展 [J]. 中国普外基础与临床杂志, 2005, 12(3): 212215.
3. 孙晓, 王永胜. 乳腺癌前哨淋巴结转移的诊断与预后 [J]. 中国肿瘤外科杂志, 2009, 1(4): 228232.
4. Goldhirsch A, Ingle JN, Gelber RD, et al. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009 [J]. Ann Oncol, 2009, 20(8): 13191329.
5. Warmuth MA, Bowen G, Prosnitz LR, et al. Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey [J]. Cancer, 1998, 83(7): 13621368.
6. Fleissig A, Fallowfield LJ, Langridge CI, et al. Postoperative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer [J]. Breast Cancer Res Treat, 2006, 95(3): 279293.
7. Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinelnode biopsy with routine axillary dissection in breast cancer [J]. N Engl J Med, 2003, 349(6): 546553.
8. Julian TB, Krag D, Brown A, et al. Preliminary technical results of NSAPBP B32, a randomized phase Ⅲ clinical trial to compare sentinel node resection to conventional axillary dissection in clinically nodenegative breast cancer patients [J]. Breast Cancer Res Treat, 2004, 88(S1): S11S12.
9. 王永胜, 欧阳涛, 王启堂, 等. 中国前哨淋巴结活检多中心协作研究CBCSG001最新资料报告 [J]. 中华乳腺病杂志(电子版), 2009, 3(3): 265272.
10. 王永胜, 左文述, 刘娟娟, 等. 乳腺癌前哨淋巴结活检替代腋窝清扫术前瞻性非随机对照临床研究 [J]. 外科理论与实践, 2006, 11(2): 104107.
11. Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer:the almanac trial [J]. J Natl Cancer Inst, 2006, 98(9): 599609.
12. Purushotham AD, Upponi S, Klevesath MB, et al. Morbidity after sentinel lymph node biopsy in primary breast cancer:results from a randomized controlled trial [J]. J Clin Oncol, 2005, 23(19): 43124321.
13. Schulze T, Mucke J, Markwardt J, et al. Longterm morbidity of patients with early breast cancer after sentinel lymph node biopsy compared to axillary lymph node dissection [J]. J Surg Oncol, 2006, 93(2): 109119.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Quality of Life after Sentinel Lymph Node Biopsy in Patients with Breast Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content