Distribution and Expression of Estrogen Receptor β Protein in Sigmoid Colon of Female Patients with Slow Transit Constipation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Guangjun ¹ , WANG Chongshu ¹ , WEI Shoujiang ¹ , LIU Baohua ² , TONG Weidong ²

1.The First Department of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China;;
2.Department of General Surgery, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China;

Corresponding author：

Keywords：

Slow transit constipation; Estrogen receptor β; Interstitial cells of Cajal

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Objective To investigate the express of ERβ protein in female slow transit constipation (STC) patients. Methods Immunohistochemistry and Western blot technique were used to detect the distribution and expression of estrogen receptor β (ERβ) protein of 20 patients with STC and 20 aged-matched controls.
Results ERβ expressions were detected in mucous layer, myenteric nerve plexus and submucous nerve plexus in two groups. In comparison with the control group, the expression of ERβ protein of STC group was much lower (P lt;0.01). The expression of ERβ protein of sigmoid colon in STC group was significantly lower than that in control group (P lt;0.05).
Conclusion The expression of ERβ protein decreased in myenteric and submucous nerve plexus of sigmoid colon tissues may involve in the pathogenesis of STC.

Citation： ZHANG Guangjun ,WANG Chongshu,WEI Shoujiang,LIU Baohua,TONG Weidong. Distribution and Expression of Estrogen Receptor β Protein in Sigmoid Colon of Female Patients with Slow Transit Constipation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(2): 122-124. doi: Copy

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2.	Konstantinopoulos PA, Kominea A, Vandoros G, et al. Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour’s dedifferentiation [J]. Eur J Cancer, 2003； 39(9): 12511258.
3.	Bharucha A, Wald A, Enck P, et al. Functional anorectal disorders [J]. Gastroenterology, 2006; 130（5）: 15101518.
4.	韩炜, 李学会, 李延青, 等. 肠黏膜雌孕激素受体表达在肠易激综合征发病机制中的作用研究 [J]. 胃肠病学和肝病学杂志, 2002; 11(4): 332334.
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6.	刘宝华. 结肠慢传输性便秘外科治疗国内外进展 [J]. 中国普外基础与临床杂志, 2007; 14(6): 630631.
7.	喻德洪，金黑鹰. 慢性非特异性便秘诊治的若干问题 [J]. 中国普外基础与临床杂志, 2003; 10(3): 207208.
8.	童卫东, 刘宝华, 熊仁平, 等. 慢传输性便秘乙状结肠ckit蛋白和mRNA [J]. 第三军医大学学报, 2004； 26(12): 10521054.
9.	Hogg A, Schirm S, Nakagoshi H, et al. Inactivation of a cMyb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of ckit but not cmyc or cdc2 [J]. Oncogene, 1997; 15(24): 28852898.
10.	CampellThompson M, Lynch IJ, Bhardwaj B. Expression of estrogen receptor (ER) subtyes ERβ and isoform in colon cancer [J]. Cancer Res, 2001; 61(2): 632640.

1. Xiao ZL, Pricolo V, Biancani P, et al. Role of progesterone signaling in the regulation of Gprotein levels in female chronic constipation [J]. Gastroenterology, 2005; 128(3): 667675.
2. Konstantinopoulos PA, Kominea A, Vandoros G, et al. Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour’s dedifferentiation [J]. Eur J Cancer, 2003； 39(9): 12511258.
3. Bharucha A, Wald A, Enck P, et al. Functional anorectal disorders [J]. Gastroenterology, 2006; 130（5）: 15101518.
4. 韩炜, 李学会, 李延青, 等. 肠黏膜雌孕激素受体表达在肠易激综合征发病机制中的作用研究 [J]. 胃肠病学和肝病学杂志, 2002; 11(4): 332334.
5. Lyford GL, He CL, Soffer E, et al. Pancolonic decrease in interstitial cells of Cajal in patients with slow transit constipation [J]. Gut, 2002; 51(4): 496501.
6. 刘宝华. 结肠慢传输性便秘外科治疗国内外进展 [J]. 中国普外基础与临床杂志, 2007; 14(6): 630631.
7. 喻德洪，金黑鹰. 慢性非特异性便秘诊治的若干问题 [J]. 中国普外基础与临床杂志, 2003; 10(3): 207208.
8. 童卫东, 刘宝华, 熊仁平, 等. 慢传输性便秘乙状结肠ckit蛋白和mRNA [J]. 第三军医大学学报, 2004； 26(12): 10521054.
9. Hogg A, Schirm S, Nakagoshi H, et al. Inactivation of a cMyb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of ckit but not cmyc or cdc2 [J]. Oncogene, 1997; 15(24): 28852898.
10. CampellThompson M, Lynch IJ, Bhardwaj B. Expression of estrogen receptor (ER) subtyes ERβ and isoform in colon cancer [J]. Cancer Res, 2001; 61(2): 632640.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Distribution and Expression of Estrogen Receptor β Protein in Sigmoid Colon of Female Patients with Slow Transit Constipation

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