Observation and Analysis of Toxic and Side Effect of Continuous Hyperthermic Peritoneal Perfusion Chemotherapy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Yibing ¹ , LIU Wei ¹ , HONG Lei ¹ , DONG Qian ¹ , CHEN Ruixin ²

1.Department of Medical Oncology, The Fourth Hospital of Hebei Medical College, Shijiazhuang 050011;;
2.Hejia Medical Device Company of Beijiao Hospital of Shunde City, Shunde 528311, Guangdong Province, China;

Corresponding author：

Keywords：

Continuous hyperthermic peritoneal perfusion chemotherapy; Malignant tumor; Toxic and side effect

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Objective To observe the toxic and side effects during the continuous hyperthermic peritoneal perfusion chemotherapy (CHPPC).
Methods Abdominal paracentesis and catheterization were performed under ultrasound guidance, then CHPPC was carried out, which was in temperature of 42-44 ℃ for 1 h. The changes of body temperature, heart rate, blood pressure, saturation of blood oxygen and respiratory frequency were recorded in 109 patients during and after perfusion, meanwhile symptoms and physical signs of abdominal region and system status such as abdominal tenderness, rebound tenderness were observed.
Results There were no significant differences of body temperature, heart rate, blood pressure, saturation of blood oxygen or respiratory frequency between before and after perfusion (P gt;0.05). There were 25 patients with abdominal pain, but in which only 3 patients with symptoms of acute abdomen, 26 patients with gastrointestinal symptoms, 20 patients with myelosuppression, and others (22 cases) with aches of puncture position which were released by symptomatic treatment.
Conclusion There are less toxic and side effect and better tolerance in patients with CHPPC application 1 month after operation.

Citation： LIU Yibing ,LIU Wei,HONG Lei,DONG Qian,CHEN Ruixin. Observation and Analysis of Toxic and Side Effect of Continuous Hyperthermic Peritoneal Perfusion Chemotherapy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(3): 237-239. doi: Copy

1.	Fujimoto S, Shrestha RD, Kokubun M, et al. Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding [J]. Ann Surg, 1988; 208(1): 3641.
2.	Yonemura Y, de Aretxabala X, Fujimura T, et al. Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study [J]. Hepatogastroenterology, 2001; 48(42): 17761782.
3.	Elias D, Sideris L, Pocard M, et al. Efficacy of intraperitoneal chemohyperthermia with oxaliplatin in colorectal peritoneal carcinomatosis. Preliminary results in 24 patients [J]. Ann Oncol, 2004; 15(5): 781785.
4.	周际昌. 实用肿瘤内科学 [M]. 第2版. 北京: 人民卫生出版社, 2000: 619625.
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6.	张珊文, 尚卫群, 吕有勇. 抑癌基因p53提高人胃癌细胞热敏感性的作用 [J].中华物理医学和康复杂志, 2000; 22(2): 9496.
7.	MoriyamaGonda N, Igawa M, Shiina H, et al. Heatinduced membrane damage combined with adriamycin on prostate carcinoma PC3 cells: correlation of cytotoxicity, permeability and Pglycoprotein or metallothionein expression [J]. Br J Urol, 1998; 82(4): 552559.
8.	张刚庆, 卿三华, 齐德林, 等. 腹腔或盆腔热灌注化疗的胃肠癌临床研究50例 [J]. 中华普通外科杂志, 2001; 16(12): 737739.
9.	Shinginasa K, Ryuidi H, Michio M, et al. Prophylactic therapy for peritoneal recurrence of gastric cancer by CHIP with MMC [J]. Cancer, 1998; 61(2): 232233.
10.	Toyota N, Strebel FR, Stephens LC, et al. Effect of altered duration of 41.5 ℃ whole body hyperthermia in combination with cisdiamminedichloroplatinum (Ⅱ) on tumor and normal tissue apoptosis and tumor response in rats [J]. Oncol Rep, 1998; 5(5): 12311236.
11.	Raaphorst GP, Mao J, Yang H, et al. Evaluation of apoptosis in four human tumour cell lines with differing sensitivities to cisplatin [J]. Anticancer Res, 1998; 18(4C): 29452951.
12.	Othman T, Goto S, Lee JB, et al. Hyperthermic enhancement of the apoptotic and antiproliferative activities of paclitaxel [J]. Pharmacology, 2001; 62(4): 208212.
13.	Shen P, Levine EA, Hall J, et al. Factors predicting survival after intraperitoneal hyperthermic chemotherapy with mitomycin C after cytoreductive surgery for patients with peritoneal carcinomatosis [J]. Arch Surg, 2003; 138(1): 2633.
14.	Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer [J]. J Clin Oncol, 2003; 21(20): 37373743.
15.	Glehen O, Osinsky D, Cotte E, et al. Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures [J]. Ann Surg Oncol, 2003; 10(8): 863869.

1. Fujimoto S, Shrestha RD, Kokubun M, et al. Intraperitoneal hyperthermic perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding [J]. Ann Surg, 1988; 208(1): 3641.
2. Yonemura Y, de Aretxabala X, Fujimura T, et al. Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study [J]. Hepatogastroenterology, 2001; 48(42): 17761782.
3. Elias D, Sideris L, Pocard M, et al. Efficacy of intraperitoneal chemohyperthermia with oxaliplatin in colorectal peritoneal carcinomatosis. Preliminary results in 24 patients [J]. Ann Oncol, 2004; 15(5): 781785.
4. 周际昌. 实用肿瘤内科学 [M]. 第2版. 北京: 人民卫生出版社, 2000: 619625.
5. 孙燕, 石远凯. 临床肿瘤内科手册 [M]. 第5版. 北京: 人民卫生出版社, 2008: 142143.
6. 张珊文, 尚卫群, 吕有勇. 抑癌基因p53提高人胃癌细胞热敏感性的作用 [J].中华物理医学和康复杂志, 2000; 22(2): 9496.
7. MoriyamaGonda N, Igawa M, Shiina H, et al. Heatinduced membrane damage combined with adriamycin on prostate carcinoma PC3 cells: correlation of cytotoxicity, permeability and Pglycoprotein or metallothionein expression [J]. Br J Urol, 1998; 82(4): 552559.
8. 张刚庆, 卿三华, 齐德林, 等. 腹腔或盆腔热灌注化疗的胃肠癌临床研究50例 [J]. 中华普通外科杂志, 2001; 16(12): 737739.
9. Shinginasa K, Ryuidi H, Michio M, et al. Prophylactic therapy for peritoneal recurrence of gastric cancer by CHIP with MMC [J]. Cancer, 1998; 61(2): 232233.
10. Toyota N, Strebel FR, Stephens LC, et al. Effect of altered duration of 41.5 ℃ whole body hyperthermia in combination with cisdiamminedichloroplatinum (Ⅱ) on tumor and normal tissue apoptosis and tumor response in rats [J]. Oncol Rep, 1998; 5(5): 12311236.
11. Raaphorst GP, Mao J, Yang H, et al. Evaluation of apoptosis in four human tumour cell lines with differing sensitivities to cisplatin [J]. Anticancer Res, 1998; 18(4C): 29452951.
12. Othman T, Goto S, Lee JB, et al. Hyperthermic enhancement of the apoptotic and antiproliferative activities of paclitaxel [J]. Pharmacology, 2001; 62(4): 208212.
13. Shen P, Levine EA, Hall J, et al. Factors predicting survival after intraperitoneal hyperthermic chemotherapy with mitomycin C after cytoreductive surgery for patients with peritoneal carcinomatosis [J]. Arch Surg, 2003; 138(1): 2633.
14. Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer [J]. J Clin Oncol, 2003; 21(20): 37373743.
15. Glehen O, Osinsky D, Cotte E, et al. Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures [J]. Ann Surg Oncol, 2003; 10(8): 863869.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Observation and Analysis of Toxic and Side Effect of Continuous Hyperthermic Peritoneal Perfusion Chemotherapy

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