Clinical Analysis of Primary Hyperthyroidism Complicated with Thyroid Carcinoma (Report of 15 Cases)_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Qinghua , HU Zhanglin , HU Jingyuan , WANG Ruihua.

Department of General Surgery, Mindong Hospital, Teaching Hospital of Fujian Medical University, Ningde 355000, Fujian Province, China;

Corresponding author：

Keywords：

Primary hyperthyroidism; Thyroid carcinoma; Surgical treatment

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Objective To analyze the clinical relationship between primary hyperthyroidism and thyroid carcinoma, and diagnosis and treatment for the combination of the two.
Methods The clinical data of 15 patients with primary hyperthyroidism complicated with thyroid carcinoma from January 1998 to December 2008 were retrospectively analyzed.
Results Fifteen cases were smoothly discharged. The morbidity was 2.56% (15/585) of primary hyperthyroidism complicated with thyroid carcinoma. There were no operative complications. Five cases showed thyroid nodules and all cases were performed thyroidectomy. Neither hyperthyroidism nor thyroid carcinoma recurred during 9 months to 10 years (average 5.5 years) follow-up.
Conclusions The diagnosis of primary hyperthyroidism complicated with thyroid carcinoma is still difficult to be made preoperatively and chiefly depend on postoperative pathology. Rational surgical treatment can result in good effectiveness and better prognosis.

Citation： ZHANG Qinghua,HU Zhanglin,HU Jingyuan,WANG Ruihua.. Clinical Analysis of Primary Hyperthyroidism Complicated with Thyroid Carcinoma (Report of 15 Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(3): 267-271. doi: Copy

1.	Olen E, Klinck GH.Hyperthyroidism and thyroid cancer [J]. Arch Pathol, 1966; 81(6): 531535.
2.	Cappelli C, Braga M, De Martino E, et al. Outcome of patients surgically treated for various forms of hyperthyroidism with differentiated thyroid cancer: experience at an endocrine center in Italy [J]. Surg Today, 2006; 36(2): 125130.
3.	Vaiana R, Perini P, Perini P, et al. Hyperthyroidism and concurrent thyroid cancer [J]. Tumori, 1999; 85(4): 247252.
4.	Taneri F, Kurudahvecioglu O, Ege B, et al. Clinical presentation and treatment of hyperthyroidism associated with thyroid cancer [J]. Endocr Regul, 2005; 39(3): 9196.
5.	Belfiore A, Russo D, Vigneri R, et al. Graves disease, thyroid nodules and thyroid cancer [J]. Clin Endocrinol, 2001; 55(6): 711718.
6.	胡作军, 王深明, 常光其, 等. 原发性甲状腺功能亢进症合并甲状腺癌 [J]. 中国实用外科杂志, 2000; 20(6): 360361.
7.	倪春明, 马远嵩. 原发性甲状腺功能亢进症合并甲状腺癌的诊治及预后 [J]. 外科理论与实践, 2004; 9(2): 143144.
8.	何永忠, 黄超有, 聂向阳. 原发性甲状腺功能亢进并发微小甲状腺癌的手术治疗 [J]. 重庆医学, 2006; 35(14): 13111312.
9.	黄华. 原发性甲状腺功能亢进症合并甲状腺癌的临床特点分析 [J]. 中国医药指南, 2008; 6(4): 3132.
10.	Gulcelik MA, Gulcelik NE, Dinc S, et al. The incidence of hyperthyroidism in patients with thyroid cancer in anarea of iodine deficiency [J]. J Surg Oncol, 2006; 94(1): 3539.
11.	张炽新, 李松奇, 陈恩碧. 原发性甲状腺功能亢进症合并甲状腺癌的临床探讨 [J]. 中国医师进修杂志, 2009; 32(11): 2123.
12.	张长丹, 周达钧, 周余堂, 等. 甲状腺机能亢进症术后残留腺体增生导致复发及预防的探讨 [J]. 职业与健康, 2001; 17(12): 171172.
13.	张宪波, 许践刚, 颜育祥, 等. 原发性甲状腺功能亢进症合并甲状腺癌的治疗 [J]. 山东医药, 2008; 48(10): 4849.
14.	Alvarez JC, Méndez JC, Morís C. Thyroid cancer treatment [J]. Ann Otolaryngol Chir Cervicofac, 2000; 117(1): 4044.
15.	张立阳, 廖朱, 赵玉沛, 等. 178例甲状腺癌诊治体会 [J]. 中国普外基础与临床杂志, 2005; 12（6）: 614615.
16.	连小兰, 白耀, 唐伟松, 等. 甲状腺功能亢进症合并甲状腺癌的临床分析 [J]. 中国医学科学院学报, 2000; 22(3): 273275.
17.	Kikuchi S, Noguchi S, Yamashita H, et al. Prognosis of small thyroid cancer in patients with Graves’ disease [J]. Br J Surg, 2006; 93(4): 434439.
18.	Lee J, Nam KH, Chung WY, et al. Clinicopathologic features and treatment outcomes in differentiated thyroid carcinoma patients with concurrent Graves’ disease [J]. J Korean Med Sci, 2008; 23(5): 796801.
19.	朱精强, 李霞, 龚日祥, 等. 原发性甲状腺功能亢进症合并甲状腺癌的临床特点 [J]. 中国普外基础与临床杂志, 1998; 5(2): 99101.

1. Olen E, Klinck GH.Hyperthyroidism and thyroid cancer [J]. Arch Pathol, 1966; 81(6): 531535.
2. Cappelli C, Braga M, De Martino E, et al. Outcome of patients surgically treated for various forms of hyperthyroidism with differentiated thyroid cancer: experience at an endocrine center in Italy [J]. Surg Today, 2006; 36(2): 125130.
3. Vaiana R, Perini P, Perini P, et al. Hyperthyroidism and concurrent thyroid cancer [J]. Tumori, 1999; 85(4): 247252.
4. Taneri F, Kurudahvecioglu O, Ege B, et al. Clinical presentation and treatment of hyperthyroidism associated with thyroid cancer [J]. Endocr Regul, 2005; 39(3): 9196.
5. Belfiore A, Russo D, Vigneri R, et al. Graves disease, thyroid nodules and thyroid cancer [J]. Clin Endocrinol, 2001; 55(6): 711718.
6. 胡作军, 王深明, 常光其, 等. 原发性甲状腺功能亢进症合并甲状腺癌 [J]. 中国实用外科杂志, 2000; 20(6): 360361.
7. 倪春明, 马远嵩. 原发性甲状腺功能亢进症合并甲状腺癌的诊治及预后 [J]. 外科理论与实践, 2004; 9(2): 143144.
8. 何永忠, 黄超有, 聂向阳. 原发性甲状腺功能亢进并发微小甲状腺癌的手术治疗 [J]. 重庆医学, 2006; 35(14): 13111312.
9. 黄华. 原发性甲状腺功能亢进症合并甲状腺癌的临床特点分析 [J]. 中国医药指南, 2008; 6(4): 3132.
10. Gulcelik MA, Gulcelik NE, Dinc S, et al. The incidence of hyperthyroidism in patients with thyroid cancer in anarea of iodine deficiency [J]. J Surg Oncol, 2006; 94(1): 3539.
11. 张炽新, 李松奇, 陈恩碧. 原发性甲状腺功能亢进症合并甲状腺癌的临床探讨 [J]. 中国医师进修杂志, 2009; 32(11): 2123.
12. 张长丹, 周达钧, 周余堂, 等. 甲状腺机能亢进症术后残留腺体增生导致复发及预防的探讨 [J]. 职业与健康, 2001; 17(12): 171172.
13. 张宪波, 许践刚, 颜育祥, 等. 原发性甲状腺功能亢进症合并甲状腺癌的治疗 [J]. 山东医药, 2008; 48(10): 4849.
14. Alvarez JC, Méndez JC, Morís C. Thyroid cancer treatment [J]. Ann Otolaryngol Chir Cervicofac, 2000; 117(1): 4044.
15. 张立阳, 廖朱, 赵玉沛, 等. 178例甲状腺癌诊治体会 [J]. 中国普外基础与临床杂志, 2005; 12（6）: 614615.
16. 连小兰, 白耀, 唐伟松, 等. 甲状腺功能亢进症合并甲状腺癌的临床分析 [J]. 中国医学科学院学报, 2000; 22(3): 273275.
17. Kikuchi S, Noguchi S, Yamashita H, et al. Prognosis of small thyroid cancer in patients with Graves’ disease [J]. Br J Surg, 2006; 93(4): 434439.
18. Lee J, Nam KH, Chung WY, et al. Clinicopathologic features and treatment outcomes in differentiated thyroid carcinoma patients with concurrent Graves’ disease [J]. J Korean Med Sci, 2008; 23(5): 796801.
19. 朱精强, 李霞, 龚日祥, 等. 原发性甲状腺功能亢进症合并甲状腺癌的临床特点 [J]. 中国普外基础与临床杂志, 1998; 5(2): 99101.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Analysis of Primary Hyperthyroidism Complicated with Thyroid Carcinoma (Report of 15 Cases)

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