Role of Interleukin, C-Reactive Protein, and Fibrinogen in Inflammatory Response of Lower Limbs Deep Vein Thrombosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Xiaoyi ¹ , YANG Lin ² , QI Guangyu ¹ , CHE Xiangming ¹

1.Department of General Surgery, The First Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an 710061, China;;
2.Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China;

Corresponding author：

Keywords：

下肢深静脉血栓; 炎症因子; 白介素; C-反应蛋白; 纤维蛋白原

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Objective To study the effect of interleukin-6,10 (IL-6,10), C-reactive protein (CRP), and fibrinogen (FIB) on inflammatory response of lower limbs deep vein thrombosis (DVT).
Methods Thirty patients with acute lower limb DVT (DVT group) and 30 volunteers (normal control group) were included in this study, and then the concentrations of serum IL-6, IL-10, CRP, and FIB were detected.
Results The concentrations of serum IL-6, IL-10, CRP, and FIB of patients in DVT group before treatment were higher than those in normal control group (P lt;0.001). Compared with before treatment, the concentrations of serum IL-6, CRP, and FIB of patients after treatment were lower in DVT group (P lt;0.001), however, the concentration of serum IL-10 was higher (P lt;0.001). There was no difference of the concentrations of serum FIB between DVT group after treatment and normal control group (P gt;0.05), but the concentrations of serum IL-6, IL-10, and CRP of patients in DVT group after treatment were higher than those in normal control group (P lt;0.05). Conclusion Inflammatory factors may involve in DVT. Therein IL-6, CRP, and FIB play important roles in acute stage of DVT, and IL-10 may have an anti-inflammatory effect.

Citation： LIU Xiaoyi ,YANG Lin,QI Guangyu,CHE Xiangming. Role of Interleukin, C-Reactive Protein, and Fibrinogen in Inflammatory Response of Lower Limbs Deep Vein Thrombosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(7): 660-663. doi: Copy

1.	张培华, 蒋米尔. 临床血管外科学 [M]. 第2版. 北京: 科学出版社, 2007: 568569.
2.	马玉奎, 赵纪春, 胡志, 等. 下肢深静脉血栓形成的诊断及综合治疗 [J]. 中国普外基础与临床杂志, 2008; 15(1): 5658.
3.	杨林, 蔡端, 祁光裕. 腹腔镜术后下肢深静脉血栓形成的相关因素分析 [J]. 中国普外基础与临床杂志, 2009; 16(6): 425428.
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5.	李正茂，庞达. 恶性肿瘤伴发下肢深静脉血栓患者血清IL6、IL8和IL10的水平及意义探讨 [J]. 齐齐哈尔医学院学报, 2008; 29(3): 262264.
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9.	杨林, 祁光裕, 李艳姿, 等. C反应蛋白与急性下肢深静脉血栓炎症反应的研究 [J]. 中国现代普通外科进展, 2007; 10(5): 398400.
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11.	Reiter M, Bucek RA, Koca N, et al. Deep vein thrombosis and systemic inflammatory response: a pilot trial [J]. Wien Klin Wochenschr, 2003; 115(34): 111114.
12.	张玥, 刘明, 王彬, 等. 深静脉血栓形成中促炎症细胞因子变化的研究 [J]. 中国现代医学杂志, 2007; 17(5): 569571.
13.	RoumenKlappe EM, den Heijer M, van Uum SH, et al. Inflammatory response in the acute phase of deep vein thrombosis [J]. J Vasc Surg, 2002; 35(4): 701706.
14.	Fox EA, Kahn SR. The relationship between inflammation and venous thrombosis. A systematic review of clinical studies [J]. Thromb Haemost, 2005; 94(2): 362365.
15.	Pandolfi A. Creactive protein: a potential new molecular link between inflammation, thrombosis and vascular cell proliferation? [J]. Cardiovasc Res, 2005; 68(1): 34.
16.	Bucek RA, Reiter M, Quehenberger P, et al. Creactive protein in the diagnosis of deep vein thrombosis [J]. Br J Haematol, 2002; 119(2): 385389.
17.	Krieger E, van Der Loo B, AmannVesti BR, et al. Creactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis [J]. J Vasc Surg, 2004; 40(4): 644649.
18.	Miyao Y, Yasue H, Ogawa H, et al. Elevated plasma interleukin6 levels in patients with acute myocardial infarction [J]. Am Heart J, 1993; 126(6): 12991304.
19.	洪梅, 魏文宁, 胡豫, 等. 急性心肌梗死患者IL6和IL10水平测定及其临床意义 [J]. 血栓与止血学, 2003; 9(2): 5861.
20.	Wakefield TW, Greenfield LJ, Rolfe MW, et al. Inflammatory and procoagulant mediator interactions in an experimental baboon model of venous thrombosis [J]. Thromb Haemost, 1993; 69(2): 164172.
21.	赛力克·马高维亚, 王护国, 罗军, 等. 一种适合动态研究的大鼠深静脉血栓动物模型 [J]. 中国普外基础与临床杂志, 2008; 15(6): 408411.
22.	Downing LJ, Strieter RM, Kadell AM, et al. IL10 regulates thrombusinduced vein wall inflammation and thrombosis [J]. J Immunol, 1998; 161(3): 14711476.
23.	Arcelus JI, Kudrna JC, Caprini JA. Venous thromboembolism following major orthopedic surgery: what is the risk after discharge? [J]. Orthopedics, 2006; 29(6): 506516.
24.	马骊, 任凤霞, 张林. 全髋关节置换后血清炎性因子表达及深静脉血栓形成57例分析 [J]. 中国组织工程研究与临床康复, 2009; 13(4): 771773.
25.	孙华, 韩旭东. 全身炎症反应综合征与凝血功能探讨 [J]. 中国微循环, 2002; 6(6): 369370.

1. 张培华, 蒋米尔. 临床血管外科学 [M]. 第2版. 北京: 科学出版社, 2007: 568569.
2. 马玉奎, 赵纪春, 胡志, 等. 下肢深静脉血栓形成的诊断及综合治疗 [J]. 中国普外基础与临床杂志, 2008; 15(1): 5658.
3. 杨林, 蔡端, 祁光裕. 腹腔镜术后下肢深静脉血栓形成的相关因素分析 [J]. 中国普外基础与临床杂志, 2009; 16(6): 425428.
4. 庄舜玖, 景在平. 炎症因子在深静脉血栓形成及转归中的作用 [J]. 上海医学, 2006; 29(7): 454457.
5. 李正茂，庞达. 恶性肿瘤伴发下肢深静脉血栓患者血清IL6、IL8和IL10的水平及意义探讨 [J]. 齐齐哈尔医学院学报, 2008; 29(3): 262264.
6. Becattini C, Agnelli G. Pathogenesis of venous thromboembolism [J]. Curr Opin Pulm Med, 2002; 8(5): 360364.
7. 周翔宇, 何延政, 何春水, 等. 急性下肢深静脉血栓形成患者IL6、IL8、IL10及TNFα的水平及意义探讨 [J]. 中国普外基础与临床杂志, 2006; 13(6): 653655.
8. Sullivan VV, Hawley AE, Farris DM, et al. Decrease in fibrin content of venous thrombi in selectindeficient mice [J]. J Surg Res, 2003; 109(1): 17.
9. 杨林, 祁光裕, 李艳姿, 等. C反应蛋白与急性下肢深静脉血栓炎症反应的研究 [J]. 中国现代普通外科进展, 2007; 10(5): 398400.
10. Tsai AW, Cushman M, Rosamond WD, et al. Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE) [J]. Am J Med, 2002; 113(8): 636642.
11. Reiter M, Bucek RA, Koca N, et al. Deep vein thrombosis and systemic inflammatory response: a pilot trial [J]. Wien Klin Wochenschr, 2003; 115(34): 111114.
12. 张玥, 刘明, 王彬, 等. 深静脉血栓形成中促炎症细胞因子变化的研究 [J]. 中国现代医学杂志, 2007; 17(5): 569571.
13. RoumenKlappe EM, den Heijer M, van Uum SH, et al. Inflammatory response in the acute phase of deep vein thrombosis [J]. J Vasc Surg, 2002; 35(4): 701706.
14. Fox EA, Kahn SR. The relationship between inflammation and venous thrombosis. A systematic review of clinical studies [J]. Thromb Haemost, 2005; 94(2): 362365.
15. Pandolfi A. Creactive protein: a potential new molecular link between inflammation, thrombosis and vascular cell proliferation? [J]. Cardiovasc Res, 2005; 68(1): 34.
16. Bucek RA, Reiter M, Quehenberger P, et al. Creactive protein in the diagnosis of deep vein thrombosis [J]. Br J Haematol, 2002; 119(2): 385389.
17. Krieger E, van Der Loo B, AmannVesti BR, et al. Creactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis [J]. J Vasc Surg, 2004; 40(4): 644649.
18. Miyao Y, Yasue H, Ogawa H, et al. Elevated plasma interleukin6 levels in patients with acute myocardial infarction [J]. Am Heart J, 1993; 126(6): 12991304.
19. 洪梅, 魏文宁, 胡豫, 等. 急性心肌梗死患者IL6和IL10水平测定及其临床意义 [J]. 血栓与止血学, 2003; 9(2): 5861.
20. Wakefield TW, Greenfield LJ, Rolfe MW, et al. Inflammatory and procoagulant mediator interactions in an experimental baboon model of venous thrombosis [J]. Thromb Haemost, 1993; 69(2): 164172.
21. 赛力克·马高维亚, 王护国, 罗军, 等. 一种适合动态研究的大鼠深静脉血栓动物模型 [J]. 中国普外基础与临床杂志, 2008; 15(6): 408411.
22. Downing LJ, Strieter RM, Kadell AM, et al. IL10 regulates thrombusinduced vein wall inflammation and thrombosis [J]. J Immunol, 1998; 161(3): 14711476.
23. Arcelus JI, Kudrna JC, Caprini JA. Venous thromboembolism following major orthopedic surgery: what is the risk after discharge? [J]. Orthopedics, 2006; 29(6): 506516.
24. 马骊, 任凤霞, 张林. 全髋关节置换后血清炎性因子表达及深静脉血栓形成57例分析 [J]. 中国组织工程研究与临床康复, 2009; 13(4): 771773.
25. 孙华, 韩旭东. 全身炎症反应综合征与凝血功能探讨 [J]. 中国微循环, 2002; 6(6): 369370.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Role of Interleukin, C-Reactive Protein, and Fibrinogen in Inflammatory Response of Lower Limbs Deep Vein Thrombosis

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