Meta-Analysis of Clinical Efficacy and Safety about Hyperthermic Intraperitoneal Perfusion Chemotherapy in Treatment of Advanced Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

BA Mingchen ¹ , CUI Shuzhong ¹ , LUO Futian ² , OUYANG Wenwei ² , TANG Yunqiang ¹ , WU Yinbing ¹

1.Department of Abdominal Surgery (Section 2), Cancer Hospital of Guangzhou Medical College, Guangzhou 510095, China;;
2.Department of Statistics, School of Public Health, Sun Yatsen University, Guangzhou 510080, China;

Corresponding author：

Keywords：

Advanced colorectal cancer; Hyperthermic intraperitoneal perfusion; Chemotherapy; Efficacy; Safety; Meta-analysis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the clinical efficacy and safety of hyperthermic intraperitoneal perfusion chemotherapy (HIPC) in treatment of advanced colorectal cancer.
Methods The Meta-analysis was applied to analyze 8 randomized controlled quantitative studies published at domestic and abroad. These patients treated by HIPC after radical operation with colorectal cancer were included for the treatment group, and those treated only by radical operation with colorectal cancer for the control group. Relative risk (RR) of outcome variable of 3-year and 5-year survival rate and safety between the two groups were compared.
Results There were 8 selected literatures, including 1 501 cases, in which 765 cases for treatment group, and 736 cases for control group. RR of 5-year survival rate of the total patients was 2.39 (95% CI: 1.66-3.45). RR of 3-year survival rate of the total patients was 2.13 (95% CI: 1.45-3.13). The results demonstrated that HIPC could improve 5-year and 3-year survival rate, and sensitivity analysis confirmed the conclusions more reliable. The security was described in 5 literatures, the available information showed smaller potential security issue.
Conclusions HIPC after radical operation of advanced colorectal cancer can increase 5-year and 3-year survival rate of patients, improve the prognosis of patients. Whether patients with increased incidence of postoperative complications related to the HIPC is no clear-cut conclusions for lack of related research.

Citation： BA Mingchen ,CUI Shuzhong,LUO Futian,OUYANG Wenwei,TANG Yunqiang,WU Yinbing. Meta-Analysis of Clinical Efficacy and Safety about Hyperthermic Intraperitoneal Perfusion Chemotherapy in Treatment of Advanced Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(7): 725-730. doi: Copy

1.	Verwaal VJ, Bruin S, Boot H, et al. 8year followup of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer [J]. Ann Surg Oncol， 2008； 15(9): 24262432.
2.	Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer [J]. J Clin Oncol， 2003； 21(20): 37373743.
3.	Elias D, Benizri E, Di Pietrantonio D, et al. Comparison of two kinds of intraperitoneal chemotherapy following complete cytoreductive surgery of colorectal peritoneal carcinomatosis[J]. Ann Surg Oncol， 2007； 14(2): 509514.
4.	吴承堂, 黄祥成, 卿三华. 直肠癌术式和热灌注化疗与预后的关系 [J]. 中华胃肠外科杂志, 2001； 4(2)： 8890.
5.	Verwaal VJ, van Ruth S, Witkamp A, et al. Longterm survival of peritoneal carcinomatosis of colorectal origin [J]. Ann Surg Oncol, 2005； 12(1): 6571.
6.	王付龙, 侯爱军, 彭正. 结直肠癌切除术中腹腔低渗热灌注化疗的临床研究 [J]. 华北国防医药, 2006； 18(2): 100102.
7.	Elias D, Lefevre JH, Chevalier J, et al. Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin [J]. J Clin Oncol, 2009； 27(5): 681685.
8.	Kianmanesh R, Scaringi S, Sabate JM, et al. Iterative cytoreductive surgery associated with hyperthermic intraperitoneal chemotherapy for treatment of peritoneal carcinomatosis of colorectal origin with or without liver metastases [J]. Ann Surg, 2007； 245(4): 597603.
9.	Yan TD. Peritoneal carcinomatosis of colorectal origin: standard of care [J]. Ann Surg, 2006； 224(4): 632633.
10.	Glockzin G, Ghali N, Lang SA, et al. Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer [J]. J Surg Oncol, 2009； 100(4): 306310.
11.	Brouquet A, Goéré D, Lefèvre JH, et al. The second procedure combining complete cytoreductive surgery and intraperitoneal chemotherapy for isolated peritoneal recurrence: postoperative course and longterm outcome [J]. Ann Surg Oncol, 2009； 16(10): 27442751.
12.	Hagendoorn J, van Lammeren G, Boerma D, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal and gastrointestinal origin shows acceptable morbidity and high survival[J]. Eur J Surg Oncol, 2009； 35(8)：833837.
13.	Huh JW, Kim YJ, Kim HR. Complete peritonectomy and intraperitoneal chemotherapy for recurrent rectal cancer with peritoneal metastasis[J]. World J Gastroenterol, 2009; 15(6): 756757.
14.	刘义冰, 刘巍, 洪雷, 等. 腹腔热灌注化疗毒副作用的观察及分析 [J]. 中国普外基础与临床杂志, 2010； 17(3): 237239.
15.	何建苗, 蒲永东, 曹志宇, 等. 胃癌患者腹腔游离癌细胞的监测与腹腔灌注化疗 [J]. 中国普外基础与临床杂志, 2002； 9(3): 156158.
16.	Franko J, Gusani NJ, Holtzman MP, et al. Multivisceral resection does not affect morbidity and survival after cytoreductive surgery and chemoperfusion for carcinomatosis from colorectal cancer [J]. Ann Surg Oncol, 2008； 15(11): 30653072.
17.	Zanon C, Bortolini M, Chiappino I, et al. Cytoreductive surgery combined with intraperitoneal chemohyperthermia for the treatment of advanced colon cancer [J]. World J Surg, 2006； 30(11): 20252032.
18.	毛忠琦, 陆耀良, 徐乃元. 腹腔化疗对大鼠结肠吻合口愈合的影响 [J]. 中国普外基础与临床杂志, 2002； 9(5): 335337.
19.	Cao C, Yan TD, Black D, et al. A systematic review and metaanalysis of cytoreductive surgery with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin [J]. Ann Surg Oncol, 2009； 16(8): 21522165.

1. Verwaal VJ, Bruin S, Boot H, et al. 8year followup of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer [J]. Ann Surg Oncol， 2008； 15(9): 24262432.
2. Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer [J]. J Clin Oncol， 2003； 21(20): 37373743.
3. Elias D, Benizri E, Di Pietrantonio D, et al. Comparison of two kinds of intraperitoneal chemotherapy following complete cytoreductive surgery of colorectal peritoneal carcinomatosis[J]. Ann Surg Oncol， 2007； 14(2): 509514.
4. 吴承堂, 黄祥成, 卿三华. 直肠癌术式和热灌注化疗与预后的关系 [J]. 中华胃肠外科杂志, 2001； 4(2)： 8890.
5. Verwaal VJ, van Ruth S, Witkamp A, et al. Longterm survival of peritoneal carcinomatosis of colorectal origin [J]. Ann Surg Oncol, 2005； 12(1): 6571.
6. 王付龙, 侯爱军, 彭正. 结直肠癌切除术中腹腔低渗热灌注化疗的临床研究 [J]. 华北国防医药, 2006； 18(2): 100102.
7. Elias D, Lefevre JH, Chevalier J, et al. Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin [J]. J Clin Oncol, 2009； 27(5): 681685.
8. Kianmanesh R, Scaringi S, Sabate JM, et al. Iterative cytoreductive surgery associated with hyperthermic intraperitoneal chemotherapy for treatment of peritoneal carcinomatosis of colorectal origin with or without liver metastases [J]. Ann Surg, 2007； 245(4): 597603.
9. Yan TD. Peritoneal carcinomatosis of colorectal origin: standard of care [J]. Ann Surg, 2006； 224(4): 632633.
10. Glockzin G, Ghali N, Lang SA, et al. Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer [J]. J Surg Oncol, 2009； 100(4): 306310.
11. Brouquet A, Goéré D, Lefèvre JH, et al. The second procedure combining complete cytoreductive surgery and intraperitoneal chemotherapy for isolated peritoneal recurrence: postoperative course and longterm outcome [J]. Ann Surg Oncol, 2009； 16(10): 27442751.
12. Hagendoorn J, van Lammeren G, Boerma D, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal and gastrointestinal origin shows acceptable morbidity and high survival[J]. Eur J Surg Oncol, 2009； 35(8)：833837.
13. Huh JW, Kim YJ, Kim HR. Complete peritonectomy and intraperitoneal chemotherapy for recurrent rectal cancer with peritoneal metastasis[J]. World J Gastroenterol, 2009; 15(6): 756757.
14. 刘义冰, 刘巍, 洪雷, 等. 腹腔热灌注化疗毒副作用的观察及分析 [J]. 中国普外基础与临床杂志, 2010； 17(3): 237239.
15. 何建苗, 蒲永东, 曹志宇, 等. 胃癌患者腹腔游离癌细胞的监测与腹腔灌注化疗 [J]. 中国普外基础与临床杂志, 2002； 9(3): 156158.
16. Franko J, Gusani NJ, Holtzman MP, et al. Multivisceral resection does not affect morbidity and survival after cytoreductive surgery and chemoperfusion for carcinomatosis from colorectal cancer [J]. Ann Surg Oncol, 2008； 15(11): 30653072.
17. Zanon C, Bortolini M, Chiappino I, et al. Cytoreductive surgery combined with intraperitoneal chemohyperthermia for the treatment of advanced colon cancer [J]. World J Surg, 2006； 30(11): 20252032.
18. 毛忠琦, 陆耀良, 徐乃元. 腹腔化疗对大鼠结肠吻合口愈合的影响 [J]. 中国普外基础与临床杂志, 2002； 9(5): 335337.
19. Cao C, Yan TD, Black D, et al. A systematic review and metaanalysis of cytoreductive surgery with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin [J]. Ann Surg Oncol, 2009； 16(8): 21522165.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Meta-Analysis of Clinical Efficacy and Safety about Hyperthermic Intraperitoneal Perfusion Chemotherapy in Treatment of Advanced Colorectal Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content