CT Perfusion with 64-Multidetector CT in Gastric Antrum Cancer and Correlation Between Functional CT and Tumor Angiogenesis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YAO Jin ¹ , CHEN Huijiao ² , HUANG Juan ¹

1.Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;;
2.Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Stomach neoplasm; Spiral computed tomography; Perfusion; Microvessel density; Angeiogenesis

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Objective To investigate perfusion features of gastric antrum cancer by 64-multidetector CT and to assess the correlation between perfusion CT parameters and immunohistochemical markers of angiogenesis in gastric cancer.
Methods Perfusion CT was performed in 30 patients with gastric antrum cancer （gastric antrum cancer group） and 24 patients with normal stomach (control group), and postoperative specimens were stained using a polyclonal antibody to VEGF and CD34. The correlation between perfusion parameters and microvessel density (MVD), and VEGF were analyzed.
Results Blood volume (BV) increased in the gastric antrum cancer group (P lt;0.01). There was no significant difference in perfusion (PF), peak enhancement (PE), or time to peak (TTP) between the gastric antrum cancer and the normal groups (P gt;0.05). BV was positively significantly correlated with MVD （r=0.522, P=0.02), but no significant correlation was found between PF （r=0.072, P=0.78), PE （r=0.253, P=0.31), or TTP （r=0.235, P=0.35) and MVD. No correlation was found between PF （r=-0.208, P=0.45), PE （r=-0.251, P=0.37), TTP（r=-0.284, P=0.31), or BV（r=-0.472, P=0.09) and VEGF.
Conclusion Blood volume can evaluate the angiogenesis of tumor and perfusion CT can be a tool to assess microvessel status in gastric antrum cancer.

Citation： YAO Jin ,CHEN Huijiao,HUANG Juan. CT Perfusion with 64-Multidetector CT in Gastric Antrum Cancer and Correlation Between Functional CT and Tumor Angiogenesis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(7): 755-759. doi: Copy

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1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [J]. CA Cancer J Clin, 2005; 55(2): 74108.
2. Insko EK, Levine MS, Birnbaum BA, et al. Benign and malignant lesions of the stomach: evaluation of CT criteria for differentiation [J]. Radiology, 2003; 228(1): 166171.
3. Rossi M, Broglia L, Graziano P, et al. Local invasion of gastric cancer: CT findings and pathologic correlation using 5mm incremental scanning, hypotonia, and water filling [J]. AJR Am J Roentgenol, 1999; 172(2): 383388.
4. Kumano S, Murakami T, Kim T, et al. T staging of gastric cancer: role of multidetector row CT [J]. Radiology, 2005; 237(3): 961966.
5. Fukuya T, Honda H, Hayashi T, et al. Lymphnode metastases: efficacy for detection with helical CT in patients with gastric cancer [J]. Radiology, 1995; 197(3): 705711.
6. Mattern J, Koomgi R, Volm M. Vascular endothelial growth factor expression and angiogenesis in nonsmall cell lung carcinoma [J]. Int J Oncol, 1995; 6: 10591062.
7. Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasiscorrelation in invasive breast carcinoma [J]. N Engl J Med, 1991; 324(1): 18.
8. 步宏, 石毓君, 吴扬. 分子病理学进展 [M]. 成都: 四川大学出版社, 2006: 124132.
9. Li SG, Ye ZY, Zhao ZS, et al. Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma [J]. World J Gastroenterol, 2008; 14(3): 421427.
10. Zhao HC, Qin R, Chen XX, et al. Microvessel density is a prognostic marker of human gastric cancer [J]. World J Gastroenterol, 2006; 12(47): 75987603.
11. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [J]. Cancer， 1996; 77(5): 858863.
12. Tateishi U, Kusumoto M, Nishihara H, et al. Contrastenhanced dynamic computed tomography for the evaluation of tumor angiogenesis in patients with lung carcinoma [J]. Cancer, 2002; 95(4): 835842.
13. Yi CA, Lee KS, Kim EA, et al. Solitary pulmonary nodules: dynamic enhanced multidetector row CT study and comparison with vascular endothelial growth factor and microvessel density [J]. Radiology, 2004; 233(1): 191199.
14. Xie Q, Zhang J, Wu PH, et al. bladder transitional cell carcinoma: correlation of contrast enhancement on computed tomography with histological grade and tumour angiogenesis [J]. Clin Radiol, 2005; 60(2): 215223.
15. Li ZP, Meng QF, Sun CH, et al. Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologicpathologic correlation [J]. World J Gastrointerol, 2005; 11(9): 12871291.
16. Bellomi M, Petralia G, Sonzogni A, et al. CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy in rectal carcinoma: initial experience [J]. Radiology, 2007; 244(2): 486493.
17. Goh V, Halligan S, Daley F, et al. Colorectal tumor vascularity: quantitative assessment with multidetector CT-do tumor perfusion measurements reflect angiogenesis? [J]. Radiology, 2008; 249(2): 510517.
18. Miles KA. Perfusion CT for the assessment of tumor vascularity: which protocol? [J]. Br J Radiol, 2003; 76 Spec No 1: S36S42.
19. 舒圣捷, 刘白鹭. CT灌注成像对肺部肿块的诊断价值 [J]. 临床放射学杂志, 2008; 27(1): 132134.
20. Fondevila C, Metges JP, Fuster J, et al. p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer [J]. Br J Cancer, 2004; 90(1): 206215.
21. Reinmuth N, Parikh AA, Ahmad SA, et al. Biology of angiogenesis in tumors of the gastrointestinal tract [J]. Microsc Res Tech, 2003; 60(2): 199207.
22. 魏学明, 顾国利, 任力, 等. 胃癌组织中EGFR、CerbB2、VEGF及COX2的表达及意义 [J]. 中国普外基础与临床杂志, 2009; 16(11): 900905.
23. 王广义, 王旭人. 胃癌VEGF和NOS的表达与肿瘤血管生成的关系 [J]. 中国普外基础与临床杂志, 2004; 11(1): 5557.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CT Perfusion with 64-Multidetector CT in Gastric Antrum Cancer and Correlation Between Functional CT and Tumor Angiogenesis

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