Hepatic Angiomyolipoma: CT Manifestations and Clinicopathologic Correlation (Report of 3 Cases)_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LU Tao ¹ , ZHOU Xiangping ² , JIANG Xinglian ³ , LIU Xiang ³

1.Department of Radiology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Chengdu 610072, China;;
2.Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;;
3.Department of Pathology, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Chengdu 610072, China;

Corresponding author：

Keywords：

Liver; Angiomyolipoma; Computed tomography; X-ray computer; HMB-45

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Objective To investigate the CT imaging features of hepatic angiomyolipoma and its clinical characteristics. Methods The clinical, radiological, and pathological data of 3 hepatic angiomyolipoma (HAML) patients were retrospectively collected, and the imaging and diagnostic features were analyzed.
Results All 3 cases were females, 2 complained of abdominal pain and one was absent of symptom. Both the laboratory examinations were normal in 2 cases, and hepatitis B virus markers were positive in one case. For CT features, the mass located in the superior anterior segment of the right hepatic lobe, in the posterior inferior segment of the right hepatic lobe, and in the left medial lobe, respectively. There were components of fat and soft tissue attenuation in these masses, and in which the CT value of the fat component was from -80 HU to -20 HU (mean -50 HU). There were enhancement in different degree and enhanced vascular imaging could be seen within the lesions. During surgery, all 3 masses were outgrowed from the hepatic lobes. Immunostainning showed HMB45 (+), αSMA (+), S100 (+)，which were bly suggestive of HAML.
Conclusion HAML is a rare benign tumor with characteristic CT appearance, and its definite diagnosis relies on the immunohistochemical staining of HMB-45.

Citation： LU Tao ,ZHOU Xiangping,JIANG Xinglian,LIU Xiang. Hepatic Angiomyolipoma: CT Manifestations and Clinicopathologic Correlation (Report of 3 Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(8): 860-864. doi: Copy

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14.	Ahmadi T, Itai Y, Takahashi M, et al. Angiomyolipoma of the liver: significance of CT and MR dynamic study [J]. Abdom imaging, 1998; 23(5): 520526.
15.	Wang YJ, Wang YC, Chien CC, et al. Diagnosis of hepatic angiomyolipoma using CT: report of three cases and review of the literature [J]. Clin Radiol, 2009; 64(3): 329334.
16.	马云海, 李健生, 陆桂君. 肝血管平滑肌脂肪瘤的临床病理分析 [J]. 中国普外基础与临床杂志, 2005; 12(2): 179180.
17.	Jiang TA, Zhao QY, Chen MY, et al. Diagnostic analysis of hepatic angiomyolipoma. Hepatobiliary Pancreat Dis Int, 2005; 4(1): 152155.

1. Tang LH, Hui P, GarciaTsao G, et al. Multiple angiomyolipomata of the liver: a case report [J]. Mod Pathol, 2002; 15(2): 167171.
2. Nguyen TT, Gorman B, Shields D, et al. Malignant hepatic angiomyolipoma: report of a case and review of literature [J]. Am J Surg Pathol, 2008; 32(5): 793798.
3. Deng YF, Lin Q, Zhang SH, et al. Malignant angiomyolipoma in the liver: a case report with pathological and molecular analysis [J]. Pathol Res Pract, 2008; 204(12): 911918.
4. Kannangai R, Diehl AM, Sicklick J, et al. Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile [J]. Hum Pathol, 2005; 36(4): 341347.
5. Nonomura A, Minato H, Kurumaya H. Angiomyolipoma predominantly composed of smooth muscle cells: problems in histologic diagnosis [J]. Histopathology, 1998; 33(1): 2027.
6. Sturtz CL, Dabbs DJ. Angiomyolipomas: the nature and expression of the HMB45 antigen [J]. Mod Pathol, 1994; 7(8): 842845.
7. Wang SN, Tsai KB, Lee KT. Hepatic angiomyolipoma with trace amounts of fat: a case report and literature review [J]. J Clin Pathol, 2006; 59(11): 11961199.
8. Tsui WM, Colombari R, Portmann BC, et al. Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants [J]. Am J Surg Pathol,1999; 23(1): 3438.
9. Petrolla AA, Xin W. Hepatic angiomyolipoma [J]. Arch Pathol Lad Med, 2003; 132(10): 16791682.
10. Low SC, Peh WC, Muttarak M, et al. Imaging features of hepatic angiomyolipoma [J]. J Med Imaging Radiat Oncol, 2008; 52(2): 118123.
11. Li T, Wang L, Yu HH, et al. Hepatic angiomyolipoma: a retrospective study of 25 cases [J]. Surg Today, 2008; 38(6): 529535.
12. Ji Y, Zhu X, Xu J, et al. Hepatic angiomyolipoma: a clinicopathologic study of 10 cases [J]. Chin Med J (Engl), 2001; 114(3): 280285.
13. Yang B, Chen WH, Li QY, et al. Hepatic angiomyolipoma: dynamic computed tomography features and clinical correlation [J]. World J Gastroenterol, 2009; 15(27): 34173420.
14. Ahmadi T, Itai Y, Takahashi M, et al. Angiomyolipoma of the liver: significance of CT and MR dynamic study [J]. Abdom imaging, 1998; 23(5): 520526.
15. Wang YJ, Wang YC, Chien CC, et al. Diagnosis of hepatic angiomyolipoma using CT: report of three cases and review of the literature [J]. Clin Radiol, 2009; 64(3): 329334.
16. 马云海, 李健生, 陆桂君. 肝血管平滑肌脂肪瘤的临床病理分析 [J]. 中国普外基础与临床杂志, 2005; 12(2): 179180.
17. Jiang TA, Zhao QY, Chen MY, et al. Diagnostic analysis of hepatic angiomyolipoma. Hepatobiliary Pancreat Dis Int, 2005; 4(1): 152155.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Hepatic Angiomyolipoma: CT Manifestations and Clinicopathologic Correlation (Report of 3 Cases)

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