Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XU Yanjun ¹ , WU Xinmin ² , GUO Yamin ²

1.Graduate College of Medical College of Qinghai University, Xining 810001, China;;
2.Department of General Surgery, People’s Hospital of Qinghai Province, Xining 810007, China;

Corresponding author：

Keywords：

Acute pancreatitis; Cytokine; Tumor necrosis factor-α; Interleukin

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the change in the cytokine network, the classification of various cytokines, interaction, and systemic impact on patients with acute pancreatitis (AP).
Methods The recently published literatures in domestic and abroad about advancement of cytokines in AP were reviewed.
Results Cytokines had a complex network and interactions. There were a variety of regulatory mechanisms. The tumor necrosis factor-α (TNF-α) and interleukin cytokines played important roles in the progress of AP. Conclusions Change of cytokines during AP is a complex process. Any separate regulation for the release of sigle factor has no significant effect on the disease. The treatment according to immune balance should be a better direction.

Citation： XU Yanjun ,WU Xinmin,GUO Yamin. Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(9): 993-996. doi: Copy

1.	Rinderknecht H. Fatal pancreatitis, a consequence of excessive leukocyte stimulation? [J]. Int J Pancreatol, 1988; 3(23): 105112.
2.	Bhatia M. Acute pancreatitis as a model of SIRS [J]. Front Biosci, 2009; 14: 20422050.
3.	Stimac D, Fisi E, Mili S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006; 40(3): 209212.
4.	Ramudo L, Manso MA, De Dios I. Biliary pancreatitisassociated ascitic fluid activates the production of tumor necrosis factoralpha in acinar cells [J]. Crit Care Med, 2005; 33(1): 143148.
5.	Norman JG, Fink GW, Franz MG. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression [J]. Arch Surg, 1995; 130(9): 966970.
6.	Gulcubuk A, Altunatmaz K, Sonmez K, et al. Effects of curcumin on tumour necrosis factorα and interleukin6 in the late phase of experimental acute pancreatitis [J]. J Vet Med A Physiol Pathol Clin Med, 2006; 53(1): 4954.
7.	林铮, 陈维雄. 粘附分子、炎症介质及细胞因子在急性胰腺炎中的作用研究进展 [J]. 国外医学消化系疾病分册, 2001; 211(3): 180183.
8.	秦仁义, 裘法祖. 炎症介质、细胞因子在急性坏死性胰腺炎发生发展中的作用 [J]. 中国普外基础与临床杂志, 1998; 5(6): 361362.
9.	张欣中, 叶子. 急性胰腺炎患者肠道屏障保护和炎性反应调控的研究 [J]. 中国微生态学杂志, 2008; 20(2): 186188.
10.	雷若庆, 韩天权, 汤耀卿, 等. TNFα在重症急性胰腺炎致病机制中的作用 [J]. 上海第二医科大学学报， 2000; 20(1): 14.
11.	Thuijls G, de Haan JJ, Derikx JP, et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock [J]. Shock, 2009; 31(2): 164169.
12.	秦勇, 党晓燕. 白藜芦醇对重症急性胰腺炎大鼠肠黏膜缺血再灌注损伤的保护作用 [J]. 中国普外基础与临床杂志, 2009; 16(10): 819823.
13.	Mayer JM. Shifting the focus from leukocyte to acinar cell: which is the more important mediator of pancreatic inflammation? [J]. Crit Care Med, 2005; 33(1): 248.
14.	Ura H, Hirata K, Yamaguchi K, et al. Mechanism of the development of organ failure [J]. Nippon Geka Gakkai Zasshi, 1998; 99(8): 485489.
15.	McKay C, Imrie CW, Baxter JN. Mononuclear phagocyte activation and acute pancreatitis [J]. Scand J Gastroenterol Suppl, 1996; 219: 3236.
16.	Sempere L, Martinez J, de Madaria E, et al. Obesity and fat distribution imply a greater systemic inflammatory response and a worse prognosis in acute pancreatitis [J]. Pancreatology, 2008; 8(3): 257264.
17.	Norman JG, Fink G, Franz M, et al. Active interleukin1 receptor required for maximal progression of acute pancreatitis [J]. Ann Surg, 1996; 223(2): 163169.
18.	Zhang XH, Zhu RM, Xu WA, et al. Therapeutic effects of caspase1 inhibitors on acute lung injury in experimental severe acute pancreatitis [J]. World J Gastroenterol, 2007; 13(4): 623627.
19.	汪宝林, 许利剑, 张建平, 等. 抗细胞因子疗法治疗实验性急性坏死性胰腺炎 [J]. 南京医科大学学报(自然科学版), 2006; 26(1): 5962.
20.	王要军, 葛文松. TNFα、IL6、TAP与急性胰腺炎严重程度的相关性研究 [J]. 中国误诊学杂志, 2009; 9(6): 12611262.
21.	葛全兴, 陈垦, 王晖. 炎症介质在急性胰腺炎发病机制中的作用研究进展 [J]. 广东药学院学报, 2008; 24(1): 9295.
22.	Chao KC, Chao KF, Chuang CC, et al. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo [J]. Br J Surg, 2006; 93(3): 332338.
23.	贺红杰, 秦春宏, 张学林, 等. CO2气腹对大鼠重症急性胰腺炎胰腺病理及IL1、IL6、CD11a/CD18和CD11b/CD18的影响 [J]. 中国普外基础与临床杂志, 2010; 17(2): 147151.
24.	Panek J, Zasada J, Poｚ＇niczek M. Microcirculatory disturbance in the course of acute pancreatitis [J]. Przegl Lek, 2007; 64(6): 435437.
25.	Pooran N, Indaram A, Singh P, et al. Cytokines (IL6, IL8, TNF): early and reliable predictors of severe acute pancreatitis [J]. J Clin Gastroenterol, 2003; 37(3): 263266.
26.	马云涛, 苏河, 王晓鹏, 等. 重组干扰素α治疗重症急性胰腺炎效果观察 [J]. 兰州大学学报(医学版), 2009; 35(3): 6063.
27.	肖彦, 王湘英. 重症急性胰腺炎与炎性细胞因子 [J]. 医学临床研究, 2008; 25(4): 703705.
28.	Moore KW, de Waal Malefyt R, Coffman RL, et al. Interleukin10 and the interleukin10 receptor [J]. Annu Rev Immunol, 2001; 19: 683765.
29.	de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10 (IL10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL10 produced by monocytes [J]. J Exp Med, 1991; 174(5): 12091220.
30.	Kusske AM, Rongione AJ, Ashley SW, et al. Interleukin10 prevents death in lethal necrotizing pancreatitis in mice [J]. Surgery, 1996; 120(2): 284288.
31.	姚婷, 王书奎, 陈军, 等. MCSF、IL10对单核细胞IL12、IL18产生及HLADR和CD80表达的影响 [J]. 细胞与分子免疫学杂志, 2004; 20(1): 6769.
32.	金忱, 倪泉兴, 张群华, 等. 急性胰腺炎大鼠TNFα mRNA、IL10 mRNA表达和胰腺细胞凋亡的研究 [J]. 中华外科杂志, 2001; 39(8): 626628.
33.	Pezzilli R, Fantini L, MorselliLabate AM. New approaches for the treatment of acute pancreatitis [J]. JOP, 2006; 7(1): 7991.
34.	Strobel O, Wachter D, Werner J, et al. Effect of a pneumoperitoneum on systemic cytokine levels, bacterial translocation, and organ complications in a rat model of severe acute pancreatitis with infected necrosis [J]. Surg Endosc, 2006; 20(12): 18971903.
35.	Mentula P, Kylnp ML, Kemppainen E, et al. Early prediction of organ failure in acute pancreatitis [J]. Duodecim, 2005; 121(12): 1331.
36.	Devière J, Le Moine O, Van Laethem JL, et al. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography [J]. Gastroenterology, 2001; 120(2): 498505.
37.	钟燕, 蔡东联, 耿珊珊, 等. 添加低聚半乳糖肠内营养对重症急性胰腺炎大鼠炎性细胞因子的作用 [J]. 上海交通大学学报（医学版）, 2009; 29(6): 689692.
38.	Curley PJ. Endotoxin, cellular immune dysfunction and acute pancreatitis [J]. Ann R Coll Surg Engl, 1996; 78(6): 531535.
39.	Curley P, Nestor M, Collins K, et al. Decreased interleukin2 production in murine acute pancreatitis: potential for immunomodulation [J]. Gastroenterology, 1996; 110(2): 583588.
40.	Ma T, Kang C, Shao H, et al. Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis [J]. Eur Surg Res, 2006; 38(5): 445450.
41.	Ryz NR, Meddings JB, Taylor CG. Longchain inulin increases dendritic cells in the Peyer’s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status [J]. Br J Nutr, 2009; 101(11): 16531663.
42.	王基, 闫军. 外源性瘦素在大鼠急性胰腺炎中的保护作用 [J]. 山西医药杂志, 2007; 36(3): 215217.
43.	Kilciler G, Musabak U, Bagci S, et al. Do the changes in the serum levels of IL2, IL4, TNFα, and IL6 reflect the inflammatory activity in the patients with postERCP pancreatitis? [J]. Clin Dev Immunol, 2008; 2008: 481560. doi: 10.1155/2008/481560.
44.	Chen CC, Wang SS, Lu RH, et al. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis [J]. Gut, 1999; 45(6): 895899.
45.	Shimizu T, Shiratori K, Sawada T, et al. Recombinant human interleukin11 decreases severity of acute necrotizing pancreatitis in mice [J]. Pancreas, 2000; 21(2): 134140.
46.	Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS [J]. Crit Care Med, 1996; 24(7): 11251128.
47.	熊建平, 文军. 急性胰腺炎中全身炎症反应综合征与抗炎症反应综合征 [J]. 国际外科学杂志, 2008; 35(9): 628630.
48.	姚欣敏, 刘牧, 李云涛, 等. 早期反复间断血滤治疗重症急性胰腺炎的临床研究 [J]. 中国普外基础与临床杂志, 2008; 15(5): 352357.

1. Rinderknecht H. Fatal pancreatitis, a consequence of excessive leukocyte stimulation? [J]. Int J Pancreatol, 1988; 3(23): 105112.
2. Bhatia M. Acute pancreatitis as a model of SIRS [J]. Front Biosci, 2009; 14: 20422050.
3. Stimac D, Fisi E, Mili S, et al. Prognostic values of IL6, IL8, and IL10 in acute pancreatitis [J]. J Clin Gastroenterol, 2006; 40(3): 209212.
4. Ramudo L, Manso MA, De Dios I. Biliary pancreatitisassociated ascitic fluid activates the production of tumor necrosis factoralpha in acinar cells [J]. Crit Care Med, 2005; 33(1): 143148.
5. Norman JG, Fink GW, Franz MG. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression [J]. Arch Surg, 1995; 130(9): 966970.
6. Gulcubuk A, Altunatmaz K, Sonmez K, et al. Effects of curcumin on tumour necrosis factorα and interleukin6 in the late phase of experimental acute pancreatitis [J]. J Vet Med A Physiol Pathol Clin Med, 2006; 53(1): 4954.
7. 林铮, 陈维雄. 粘附分子、炎症介质及细胞因子在急性胰腺炎中的作用研究进展 [J]. 国外医学消化系疾病分册, 2001; 211(3): 180183.
8. 秦仁义, 裘法祖. 炎症介质、细胞因子在急性坏死性胰腺炎发生发展中的作用 [J]. 中国普外基础与临床杂志, 1998; 5(6): 361362.
9. 张欣中, 叶子. 急性胰腺炎患者肠道屏障保护和炎性反应调控的研究 [J]. 中国微生态学杂志, 2008; 20(2): 186188.
10. 雷若庆, 韩天权, 汤耀卿, 等. TNFα在重症急性胰腺炎致病机制中的作用 [J]. 上海第二医科大学学报， 2000; 20(1): 14.
11. Thuijls G, de Haan JJ, Derikx JP, et al. Intestinal cytoskeleton degradation precedes tight junction loss following hemorrhagic shock [J]. Shock, 2009; 31(2): 164169.
12. 秦勇, 党晓燕. 白藜芦醇对重症急性胰腺炎大鼠肠黏膜缺血再灌注损伤的保护作用 [J]. 中国普外基础与临床杂志, 2009; 16(10): 819823.
13. Mayer JM. Shifting the focus from leukocyte to acinar cell: which is the more important mediator of pancreatic inflammation? [J]. Crit Care Med, 2005; 33(1): 248.
14. Ura H, Hirata K, Yamaguchi K, et al. Mechanism of the development of organ failure [J]. Nippon Geka Gakkai Zasshi, 1998; 99(8): 485489.
15. McKay C, Imrie CW, Baxter JN. Mononuclear phagocyte activation and acute pancreatitis [J]. Scand J Gastroenterol Suppl, 1996; 219: 3236.
16. Sempere L, Martinez J, de Madaria E, et al. Obesity and fat distribution imply a greater systemic inflammatory response and a worse prognosis in acute pancreatitis [J]. Pancreatology, 2008; 8(3): 257264.
17. Norman JG, Fink G, Franz M, et al. Active interleukin1 receptor required for maximal progression of acute pancreatitis [J]. Ann Surg, 1996; 223(2): 163169.
18. Zhang XH, Zhu RM, Xu WA, et al. Therapeutic effects of caspase1 inhibitors on acute lung injury in experimental severe acute pancreatitis [J]. World J Gastroenterol, 2007; 13(4): 623627.
19. 汪宝林, 许利剑, 张建平, 等. 抗细胞因子疗法治疗实验性急性坏死性胰腺炎 [J]. 南京医科大学学报(自然科学版), 2006; 26(1): 5962.
20. 王要军, 葛文松. TNFα、IL6、TAP与急性胰腺炎严重程度的相关性研究 [J]. 中国误诊学杂志, 2009; 9(6): 12611262.
21. 葛全兴, 陈垦, 王晖. 炎症介质在急性胰腺炎发病机制中的作用研究进展 [J]. 广东药学院学报, 2008; 24(1): 9295.
22. Chao KC, Chao KF, Chuang CC, et al. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo [J]. Br J Surg, 2006; 93(3): 332338.
23. 贺红杰, 秦春宏, 张学林, 等. CO2气腹对大鼠重症急性胰腺炎胰腺病理及IL1、IL6、CD11a/CD18和CD11b/CD18的影响 [J]. 中国普外基础与临床杂志, 2010; 17(2): 147151.
24. Panek J, Zasada J, Poｚ＇niczek M. Microcirculatory disturbance in the course of acute pancreatitis [J]. Przegl Lek, 2007; 64(6): 435437.
25. Pooran N, Indaram A, Singh P, et al. Cytokines (IL6, IL8, TNF): early and reliable predictors of severe acute pancreatitis [J]. J Clin Gastroenterol, 2003; 37(3): 263266.
26. 马云涛, 苏河, 王晓鹏, 等. 重组干扰素α治疗重症急性胰腺炎效果观察 [J]. 兰州大学学报(医学版), 2009; 35(3): 6063.
27. 肖彦, 王湘英. 重症急性胰腺炎与炎性细胞因子 [J]. 医学临床研究, 2008; 25(4): 703705.
28. Moore KW, de Waal Malefyt R, Coffman RL, et al. Interleukin10 and the interleukin10 receptor [J]. Annu Rev Immunol, 2001; 19: 683765.
29. de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10 (IL10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL10 produced by monocytes [J]. J Exp Med, 1991; 174(5): 12091220.
30. Kusske AM, Rongione AJ, Ashley SW, et al. Interleukin10 prevents death in lethal necrotizing pancreatitis in mice [J]. Surgery, 1996; 120(2): 284288.
31. 姚婷, 王书奎, 陈军, 等. MCSF、IL10对单核细胞IL12、IL18产生及HLADR和CD80表达的影响 [J]. 细胞与分子免疫学杂志, 2004; 20(1): 6769.
32. 金忱, 倪泉兴, 张群华, 等. 急性胰腺炎大鼠TNFα mRNA、IL10 mRNA表达和胰腺细胞凋亡的研究 [J]. 中华外科杂志, 2001; 39(8): 626628.
33. Pezzilli R, Fantini L, MorselliLabate AM. New approaches for the treatment of acute pancreatitis [J]. JOP, 2006; 7(1): 7991.
34. Strobel O, Wachter D, Werner J, et al. Effect of a pneumoperitoneum on systemic cytokine levels, bacterial translocation, and organ complications in a rat model of severe acute pancreatitis with infected necrosis [J]. Surg Endosc, 2006; 20(12): 18971903.
35. Mentula P, Kylnp ML, Kemppainen E, et al. Early prediction of organ failure in acute pancreatitis [J]. Duodecim, 2005; 121(12): 1331.
36. Devière J, Le Moine O, Van Laethem JL, et al. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography [J]. Gastroenterology, 2001; 120(2): 498505.
37. 钟燕, 蔡东联, 耿珊珊, 等. 添加低聚半乳糖肠内营养对重症急性胰腺炎大鼠炎性细胞因子的作用 [J]. 上海交通大学学报（医学版）, 2009; 29(6): 689692.
38. Curley PJ. Endotoxin, cellular immune dysfunction and acute pancreatitis [J]. Ann R Coll Surg Engl, 1996; 78(6): 531535.
39. Curley P, Nestor M, Collins K, et al. Decreased interleukin2 production in murine acute pancreatitis: potential for immunomodulation [J]. Gastroenterology, 1996; 110(2): 583588.
40. Ma T, Kang C, Shao H, et al. Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis [J]. Eur Surg Res, 2006; 38(5): 445450.
41. Ryz NR, Meddings JB, Taylor CG. Longchain inulin increases dendritic cells in the Peyer’s patches and increases ex vivo cytokine secretion in the spleen and mesenteric lymph nodes of growing female rats, independent of zinc status [J]. Br J Nutr, 2009; 101(11): 16531663.
42. 王基, 闫军. 外源性瘦素在大鼠急性胰腺炎中的保护作用 [J]. 山西医药杂志, 2007; 36(3): 215217.
43. Kilciler G, Musabak U, Bagci S, et al. Do the changes in the serum levels of IL2, IL4, TNFα, and IL6 reflect the inflammatory activity in the patients with postERCP pancreatitis? [J]. Clin Dev Immunol, 2008; 2008: 481560. doi: 10.1155/2008/481560.
44. Chen CC, Wang SS, Lu RH, et al. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis [J]. Gut, 1999; 45(6): 895899.
45. Shimizu T, Shiratori K, Sawada T, et al. Recombinant human interleukin11 decreases severity of acute necrotizing pancreatitis in mice [J]. Pancreas, 2000; 21(2): 134140.
46. Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS [J]. Crit Care Med, 1996; 24(7): 11251128.
47. 熊建平, 文军. 急性胰腺炎中全身炎症反应综合征与抗炎症反应综合征 [J]. 国际外科学杂志, 2008; 35(9): 628630.
48. 姚欣敏, 刘牧, 李云涛, 等. 早期反复间断血滤治疗重症急性胰腺炎的临床研究 [J]. 中国普外基础与临床杂志, 2008; 15(5): 352357.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis

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