Value of Indocyanine Green Test by Pulse Dye-Densitometry to Evaluate Liver Dysfunction of Hepatic Carcinoma Patient Undergone Hepatectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

DU Zhenggui , LI Bo , FENG Xi , YIN Jie , YANLnan , WEN Tianfu , ZENG Yong

Department of Hepatic and Peripheral Vascular Surgery, West China Hospital of Sichuan University, Chengdu 610041, ChinaCorresponding Author: LI Bo, E-mail:cdlibo@medmail.com.cn;

Corresponding author：

Keywords：

Hepatic function reserve; Indocyanine green test; Hepatectomy

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Objective To evaluate the effect of pulse dye-densitometry by indocyanine green test (PDD-ICG)on the assessment of hepatic function reserve. MethodsSeventy-five hepatic carcinoma patients aimed to accept hepatectomy from March 2007 to February 2008 at West China Hospital were prospectively included in this study.Patients were grouped by dysfunction grade of hepatic function and the indexes before operation were compared.Furthermore, patients were grouped by K and R15 value to compare the moderate and severe liver dysfunction ratio, respectively. ResultsSixty cases manifested slight liver dysfunction,12 cases manifested moderate liver dysfunction,and 3 cases manifested severe liver dysfunction(the latter was took into moderate group due to the cases were too few).The difference of Child-Pugh score and common liver function examination indexes such as PT and INR before operation was not significant betweentwo groups(P＞0.05).ButPDD-ICG experiment indexes(K and R15)were remarkable different betweentwo groups(P＜0.05).The patients were divided into two groups according to K and R15 value,respectively.The rate of moderate and severe liver dysfunction was significant different between K＜0.158/min groupand K≥0.158/min group(47.1% vs. 12.1%,P＜0.05),and likewise moderate and severe liver dysfunction was significant different between R15≤10% group and R15＞10% group(15.9% vs.41.7%,P＜0.05）. ConclusionPDD-ICG is an effective and easyto evaluate hepatic function reserve of patient undergone hepatectomy.Therefore,it may give clinical instruction to predict and avoid the liver dysfunction after operation.

Citation： DU Zhenggui,LI Bo,FENG Xi,YIN Jie,YANLnan,WEN Tianfu,ZENG Yong. Value of Indocyanine Green Test by Pulse Dye-Densitometry to Evaluate Liver Dysfunction of Hepatic Carcinoma Patient Undergone Hepatectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(2): 133-136. doi: Copy

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2.	Lau H,Man K,Fan ST,et al. Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy[Ｊ].Br J Surg,1997; 84(9)： 1255.
3.	Hemming AW,Scudamore CH,Shackleton CR,et al. Indocyanine green clearance as a predictor of successful hepatic resection in cirrhotic patients [Ｊ]. Am J Surg,1992; 163(5)： 515.
4.	杨建国，李奇志.门静脉高压症患者术前肝功能储备的相关因素分析[Ｊ].中国普外基础与临床杂志， 2005； 12（6）： 616.
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6.	Iijima T,Aoyagi T,Iwao Y,et al.Cardiac output and circulating blood volume analysis by pulse dye-densitometry [Ｊ].J Clin Monit，1997; 13(2)： 81.
7.	Van Thiel DH,Wright HI, Fagiuoli S,et al. Preoperative evaluation of a patient for hepatic surgery[Ｊ]. J Surg Oncol Suppl, 1993; 53(S3)： 49.
8.	潘华锋，陈孝平，邹明丽，等. CT检查预测肝癌手术切除安全性的价值[Ｊ]. 肝胆外科杂志， 2000; 8(3)：185.
9.	Sakka SG, Koeck H,Meier-Hellmann A.Measurement of indocyanine green plasma disappearance rate by two different dosages [Ｊ]. Intensive Care Med,2004; 30(3)： 506.
10.	Hunton DB,Bollman JL,Hoffman HN.Studies of hepatic function with indocyanine green [Ｊ].Gastroenterology,1960; 39： 713.
11.	Faybik P,Hetz H.Plasma disappearance rate of indocyanine green in liver dysfunction [Ｊ]. Transplant Proc,2006; 38(3)： 801.
12.	Sakka SG,Reinhart K,Meier-Hellmann A.Prognostic value of the indocyanine green plasma disappearance rate in critically ill patients [Ｊ].Chest,2002;122(5)： 1715.
13.	Watanabe Y,Kumon K.Assessment by pulse dye-densitometry indocyanine green(ICG)clearance test of hepatic function of patients before cardiac surgery:its value as a predictor of serious postoperative liver dysfunction [Ｊ].J Cardiothorac Vasc Anesth,1999;13(3)： 299.
14.	Hanazaki K,Matsushita A,Nakagawa K,et al.Risk factors of long-term survival and recurrence after curative resection of hepatocellular carcinoma [Ｊ].Hepatogastroenterology,2005; 52(62)： 552.
15.	黄冰，张运龙. 循环血量的床边无创监测－脉搏染料密度分光光度测定法[Ｊ].国外医学·麻醉学与复苏分册， 2000； 21(4)： 208.
16.	Clemmesen JO,Tygstrup N,Ott P.Hepatic plasma flow estimated according to Fick’s principle in patients with hepatic encephalopathy:evaluation of indocyanine green and D-sorbitol as test substances [Ｊ].Hepatology,1998;27(3)： 666.
17.	Kawasaki S,Sugiyama Y,Iga T,et al.Pharmacokinetic study on the hepatic uptake of indocyanine green in cirrhotic patients [Ｊ].Am J Gastroenterol,1985;80(10)： 801.
18.	Moody FG,Rikkers LF,Aldrete JS.Estimation of the functional reserve of human liver [Ｊ].Ann Surg,1974; 180(4)： 592.
19.	Nonami T,Nakao A,Kurokawa T,et al.Blood loss and ICG clearance as best prognostic markers of post-hepatectomy liver failure [Ｊ].Hepatogastroenterology,1999;46(27)： 1669.
20.	Ishikawa M,Yogita S,Miyake H,et al.Clarification of risk factors for hepatectomy in patients with hepatocellular carcinoma [Ｊ].Hepatogastroenterology,2002；49(48)： 1625.
21.	淮明生，戴朝六，朱兴，等.肝癌患者术前ICG R15水平与术后并发症的相关分析 [Ｊ].肝胆外科杂志， 2002； 10(1)： 31.
22.	ImaiT,Takahashi K,Goto F,et al.Measurement of blood concentration of indocyanine green by pulse dye densitometry comparison with the conventional spectrophotometric method [Ｊ].J Clin Monit Comput,1998;14(7-8)： 477.
23.	Hsieh CB,Chen CJ,Chen TW,et al.Accuracy of indocyanine green pulse spectrophotometry clearance test of liver function prediction in transplanted patients [Ｊ]. World J Gastroenterol,2004;10(16)： 2394.
24.	劳向明，张亚奇，关远祥，等.肝癌术前ICG R15测定对肝脏储备功能的评估 [Ｊ].癌症， 2004； 23(10)： 1213.

1. 丁佑铭，张爱民，刘吉奎，等. ICG R15和OGTT预测肝癌患者肝脏储备功能的价值 [Ｊ]. 中国普通外科杂志， 2001； 10(2)： 162.
2. Lau H,Man K,Fan ST,et al. Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy[Ｊ].Br J Surg,1997; 84(9)： 1255.
3. Hemming AW,Scudamore CH,Shackleton CR,et al. Indocyanine green clearance as a predictor of successful hepatic resection in cirrhotic patients [Ｊ]. Am J Surg,1992; 163(5)： 515.
4. 杨建国，李奇志.门静脉高压症患者术前肝功能储备的相关因素分析[Ｊ].中国普外基础与临床杂志， 2005； 12（6）： 616.
5. Poon RT,Fan ST.Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome [Ｊ].Liver Transpl,2004; 10(2 Suppl 1)： S39.
6. Iijima T,Aoyagi T,Iwao Y,et al.Cardiac output and circulating blood volume analysis by pulse dye-densitometry [Ｊ].J Clin Monit，1997; 13(2)： 81.
7. Van Thiel DH,Wright HI, Fagiuoli S,et al. Preoperative evaluation of a patient for hepatic surgery[Ｊ]. J Surg Oncol Suppl, 1993; 53(S3)： 49.
8. 潘华锋，陈孝平，邹明丽，等. CT检查预测肝癌手术切除安全性的价值[Ｊ]. 肝胆外科杂志， 2000; 8(3)：185.
9. Sakka SG, Koeck H,Meier-Hellmann A.Measurement of indocyanine green plasma disappearance rate by two different dosages [Ｊ]. Intensive Care Med,2004; 30(3)： 506.
10. Hunton DB,Bollman JL,Hoffman HN.Studies of hepatic function with indocyanine green [Ｊ].Gastroenterology,1960; 39： 713.
11. Faybik P,Hetz H.Plasma disappearance rate of indocyanine green in liver dysfunction [Ｊ]. Transplant Proc,2006; 38(3)： 801.
12. Sakka SG,Reinhart K,Meier-Hellmann A.Prognostic value of the indocyanine green plasma disappearance rate in critically ill patients [Ｊ].Chest,2002;122(5)： 1715.
13. Watanabe Y,Kumon K.Assessment by pulse dye-densitometry indocyanine green(ICG)clearance test of hepatic function of patients before cardiac surgery:its value as a predictor of serious postoperative liver dysfunction [Ｊ].J Cardiothorac Vasc Anesth,1999;13(3)： 299.
14. Hanazaki K,Matsushita A,Nakagawa K,et al.Risk factors of long-term survival and recurrence after curative resection of hepatocellular carcinoma [Ｊ].Hepatogastroenterology,2005; 52(62)： 552.
15. 黄冰，张运龙. 循环血量的床边无创监测－脉搏染料密度分光光度测定法[Ｊ].国外医学·麻醉学与复苏分册， 2000； 21(4)： 208.
16. Clemmesen JO,Tygstrup N,Ott P.Hepatic plasma flow estimated according to Fick’s principle in patients with hepatic encephalopathy:evaluation of indocyanine green and D-sorbitol as test substances [Ｊ].Hepatology,1998;27(3)： 666.
17. Kawasaki S,Sugiyama Y,Iga T,et al.Pharmacokinetic study on the hepatic uptake of indocyanine green in cirrhotic patients [Ｊ].Am J Gastroenterol,1985;80(10)： 801.
18. Moody FG,Rikkers LF,Aldrete JS.Estimation of the functional reserve of human liver [Ｊ].Ann Surg,1974; 180(4)： 592.
19. Nonami T,Nakao A,Kurokawa T,et al.Blood loss and ICG clearance as best prognostic markers of post-hepatectomy liver failure [Ｊ].Hepatogastroenterology,1999;46(27)： 1669.
20. Ishikawa M,Yogita S,Miyake H,et al.Clarification of risk factors for hepatectomy in patients with hepatocellular carcinoma [Ｊ].Hepatogastroenterology,2002；49(48)： 1625.
21. 淮明生，戴朝六，朱兴，等.肝癌患者术前ICG R15水平与术后并发症的相关分析 [Ｊ].肝胆外科杂志， 2002； 10(1)： 31.
22. ImaiT,Takahashi K,Goto F,et al.Measurement of blood concentration of indocyanine green by pulse dye densitometry comparison with the conventional spectrophotometric method [Ｊ].J Clin Monit Comput,1998;14(7-8)： 477.
23. Hsieh CB,Chen CJ,Chen TW,et al.Accuracy of indocyanine green pulse spectrophotometry clearance test of liver function prediction in transplanted patients [Ｊ]. World J Gastroenterol,2004;10(16)： 2394.
24. 劳向明，张亚奇，关远祥，等.肝癌术前ICG R15测定对肝脏储备功能的评估 [Ｊ].癌症， 2004； 23(10)： 1213.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value of Indocyanine Green Test by Pulse Dye-Densitometry to Evaluate Liver Dysfunction of Hepatic Carcinoma Patient Undergone Hepatectomy

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