Clinical Analysis of Pingyangmycin in Treatment of Body Surface Hemangioma in Children (Report of １６５８Cases)_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHENG Jianghua , CHEN Kai

Department of Vascular Surgery， Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, Sichuan Province, ChinaCorresponding Author: ZHENG Jiang-hua, E-mail: zhengjianghua@126.com;

Corresponding author：

Keywords：

Pingyangmycin; Hemangioma of body surface; Children

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　Objective 　To evaluate the therapeutic effects of pingyangmycin in treatment of body surface hemangioma in children.
　Methods 　The clinical data of 1 658 children patients with hemangioma on body surface in which pingyangmycin was injected between January 1997 and January 2008 were analyzed retrospectively．
　Results 　All 1 658 patients were observed for 6-12 months, with average of 10.83 months．　The total effective rate was 97.09%. Compared among different types of hemangioma, total effective rate had significant difference (χ2=203.12， P＜0.01), and complete remission (CR) rate had significant difference (χ2=287.97， P＜0.01). The therapeutic effect of pingyangmycin in treatment of cavernous hemangioma was better than that of strawberry hemangioma, mixed hemangioma and portwine stain, which was better instrawberry hemangioma than mixed hemangioma and portwine stain, and which was lower in portwine stain than other hemangiomas. Fifty-four patients (3.26%) caught partial necrotic ulcer of hemangioma. There were 418 cases (25.21%) of fever and 3 cases (0.18%) of allergic shock.
　Conclusion 　Intratumorally pingyangmycin injection is a simple， safe and effective therapy for hemangioma of body surface in children．

Citation： ZHENG Jianghua,CHEN Kai. Clinical Analysis of Pingyangmycin in Treatment of Body Surface Hemangioma in Children (Report of １６５８Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(3): 226-229. doi: Copy

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19.	姜锋, 黄贤胜, 邢志俐. 平阳霉素致过敏性休克1 例 [Ｊ]. 中国医院药学杂志, 2007; 27(10):1490.
20.	魏学兰, 申月艳, 程琳. 盐酸平阳霉素静脉滴注致肺间质纤维化1例的原因分析 [Ｊ].中国医药导报, 2007; 34(4):65.

1. Chiller KG, Passaro D, Frieden IJ. Hemangiomas of infancy：clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex [Ｊ]. Arch Dermatol, 2002; 138(12):1567.
2. 伍尚敏, 鲁开化. 血管瘤药物治疗的现状 [Ｊ]. 中国美容医学, 2007; 16(1):133.
3. 林晓曦. 血管瘤和血管畸形：经验、进展与挑战 [Ｊ]. 中华整形外科杂志, 2007; 23(2): 81.
4. 赵飞跃, 易贤广, 李铁华, 等. 低浓度低剂量平阳霉素局部注射治疗婴幼儿血管瘤的临床观察 [Ｊ]. 南华大学学报：医学版, 2006; 34(1):60.
5. 孟康, 王贺伟. 平阳霉素治疗颌面部血管瘤182例疗效分析 [Ｊ]. 肿瘤基础与临床, 2006; 19(4):331.
6. Folkman J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis [Ｊ]. N Engl J Med, 1995; 333(26):1757.
7. Liekens S, Verbeken E, Vandeputte M, et al. A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470 [Ｊ]. Cancer Res, 1999; 59(10):2376.
8. 李南, 陈幸生, 陈大良. Caspase-3 在血管瘤组织中的表达及其意义 [Ｊ]. 中国普外基础与临床杂志，　2004; 11(4):311.
9. Silverman RA. Hemangiomas and vascular malformations [Ｊ]. Pediatr Clin North Am, 1991; 38(4):811.
10. 董自立, 雍磊, 史秀云. 平阳霉素局部注射治疗小儿体表血管瘤286例 [Ｊ]. 临床军医杂志, 2008； 36(1):83.
11. 周卫兵, 范红渠, 郝鲁峰, 等. 平阳霉素对人脐静脉内皮细胞系ECV304的抑制作用及其机制的实验研究 [Ｊ]. 口腔医学研究, 2007； 23(1):42.
12. 伍尚敏, 鲁开化, 赵亚南，等. 平阳霉素对血管瘤内皮细胞的作用 [Ｊ]. 中国美容整形外科杂志, 2008; 19(2):140.
13. 徐伟立, 牛爱国, 李索林, 等. 平阳霉素乳剂对增生期毛细血管瘤细胞凋亡的诱导 [Ｊ]. 中华整形外科杂志, 2006; 22(5):362.
14. 野战涛, 牛爱国, 张玉斌. 平阳霉素乳剂对增殖期毛细血管瘤组织中VEGF 和bFGF的影响 [Ｊ]. 河北医药, 2007; 29(1):44.
15. 钟爱梅, 顾东明, 周宇丹, 等. 小儿体表血管瘤的治疗及疗效分析 [Ｊ]. 中华医学杂志, 2007; 31(3):187.
16. 郑俊鸿, 李林芬, 林静霞, 等. 平阳霉素瘤体内注射治疗小儿体表血管瘤的临床研究 [Ｊ]. 河北医学, 2006; 12(1):22.
17. 董欣竞, 周德凯, 李晓庆. 瘤内注射治疗婴幼儿颌面部血管瘤 [Ｊ]. 重庆医科大学学报, 2006; 31(6):886.
18. 陈开, 戴毅, 郑江华, 等. 平阳霉素局部注射治疗头面部血管瘤(附452例报告) [Ｊ]. 川北医学院学报, 2006; 26(6):516.
19. 姜锋, 黄贤胜, 邢志俐. 平阳霉素致过敏性休克1 例 [Ｊ]. 中国医院药学杂志, 2007; 27(10):1490.
20. 魏学兰, 申月艳, 程琳. 盐酸平阳霉素静脉滴注致肺间质纤维化1例的原因分析 [Ｊ].中国医药导报, 2007; 34(4):65.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Analysis of Pingyangmycin in Treatment of Body Surface Hemangioma in Children (Report of １６５８Cases)

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Analysis of Pingyangmycin in Treatment of Body Surface Hemangioma in Children (Report of １ ６５８Cases)

Abstract Full text Figures/Tables Video References Cited by

Format

Content

Clinical Analysis of Pingyangmycin in Treatment of Body Surface Hemangioma in Children (Report of １６５８Cases)