Research Progress of Promoting Function of Matrix Metalloproteinases in Gastric Cancer via Regulating Microenvironment_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIANG Zhouhua , YU Jiwei , JIANG Bojian

Department of General Surgery, No.3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, ChinaCorresponding Author: JIANG Bo-jian, E-mail: jiang_md@hotmail.com;

Corresponding author：

Keywords：

Matrix metalloproteinase; Gastric cancer; Proliferation; Invasion; Metastasis; Angiogenesis; Apoptosis

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Objective 　To summarize the role of matrix metalloproteinases (MMPs) in occurrence and development of gastric cancer.
Methods 　Domestic and international publications online involving MMPs of gastric cancer in recent years were collected and reviewed.
Results 　The occurrence and development of gastric cancer was a multi-step and multi-factorial complicated progress, whose etiology and pathogenesis were still unclarified. MMPs were a class of proteolytic enzymes, which played an important role in the proliferation, metastasis, angiogenesis of gastric cancer and apoptosis of tumor cells and their surrounding normal cells by regulating the microenvironment of the growth of tumor.
Conclusion 　MMPs promote the evolution of gastric cancer in variable ways, the mechanisms of which should be comprehended to provide a theoretical basis for the future treatment of gastric cancer.

Citation： JIANG Zhouhua,YU Jiwei,JIANG Bojian. Research Progress of Promoting Function of Matrix Metalloproteinases in Gastric Cancer via Regulating Microenvironment. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(9): 768-772. doi: Copy

1.	张鹏, 俞继卫, 姜波健. 肿瘤干细胞与胃肠道癌发生和转移 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(1): 81-84.
2.	Woessner JF Jr. MMPs and TIMPs－an historical perspective [Ｊ]. Mol Biotechnol, 2002; 22(1): 33-49.
3.	McCawley LJ, Matrisian LM. Matrix metalloproteinases: th-ey’re not just for matrix anymore! [Ｊ]. Curr Opin Cell Biol, 2001; 13(5): 534-540.
4.	Yu WH, Woessner JF Jr, McNeish JD, et al. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling [Ｊ]. Genes Dev, 2002; 16(3): 307-323.
5.	Suzuki M, Raab G, Moses MA, et al. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site [Ｊ]. J Biol Chem, 1997; 272(50): 31730-31737.
6.	Rauvala M, Aglund K, Puistola U, et al. Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression [Ｊ]. Int J Gynecol Cancer, 2006; 16(3): 1297-1302.
7.	Tatti O, Vehvilinen P, Lehti K, et al. MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1 [Ｊ]. Exp Cell Res, 2008； 314(13): 2501-2514.
8.	Puthawala K, Hadjiangelis N, Jacoby SC, et al. Inhibition of integrin αvβ6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis [Ｊ]. Am J Respir Crit Care Med, 2008; 177(1): 82-90.
9.	Miyamoto S, Nakamura M, Yano K, et al. Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-Ⅱ via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix [Ｊ]. Cancer Sci, 2007; 98(5): 685-691.
10.	Mysliwy J, Dingley AJ, Sedlacek R, et al. Structural characterization and binding properties of the hemopexin-like domain of the matrixmetalloproteinase-19 [Ｊ]. Protein Expr Purif, 2006; 46(2): 406-413.
11.	Gennigens C, Menetrier-Caux C, Droz JP. Insulin-like gro-wth factor (IGF) family and prostate cancer [Ｊ]. Crit Rev Oncol Hematol, 2006; 58(2): 124-145.
12.	Uttamsingh S, Bao X, Nguyen KT, et al. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells [Ｊ]. Oncogene, 2008; 27(18): 2626-2634.
13.	Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer [Ｊ]. Endocr Relat Cancer, 2004; 11(4): 709-724.
14.	Zheng H, Takahashi H, Murai Y, et al. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Anticancer Res, 2006; 26(5A): 3579-3583.
15.	Zheng HC, Sun JM, Li XH, et al. Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Pathol Int, 2003; 53(10): 659-666.
16.	Yasui W, Oue N, Aung PP, et al. Molecular-pathological prognostic factors of gastric cancer: a review [Ｊ]. Gastric Cancer, 2005; 8(2): 86-94.
17.	Elnemr A, Yonemura Y, Bandou E, et al. Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer [Ｊ]. Gastric Cancer, 2003; 6(1): 30-38.
18.	严冬, 沈琳, 吕尤勇. MMP-11在胃癌患者血清中的表达及临床意义 [Ｊ]. 中国癌症杂志, 2007; 17(12): 968-972.
19.	Friedl P, Brcker EB. The biology of cell locomotion within three-dimensional extracellular matrix [Ｊ]. Cell Mol Life Sci, 2000; 57(1): 41-64.
20.	Dittmar T, Heyder C, Gloria-Maercker E, et al. Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner [Ｊ]. Clin Exp Metastasis, 2008; 25(1): 11-32.
21.	Hornebeck W, Emonard H, Maquart FX, et al. Proteolysis directed by the extracellular matrix [Ｊ]. J Soc Biol, 2003; 197(1): 25-30.
22.	Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail’s pace [Ｊ]. Int J Biochem Cell Biol, 2007; 39(6): 1082-1088.
23.	徐胜军, 胡炳奎, 凌志强, 等. CD44v6在胃癌中的表达及其临床意义 [Ｊ]. 中国普外基础与临床杂志, 2006; 13(1): 42-44.
24.	Giannelli G, Falk-Marzillier J, Schiraldi O, et al. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5 [Ｊ]. Science, 1997; 277(5323): 225-228.
25.	Nisato RE, Hosseini G, Sirrenberg C, et al. Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and αvβ3 are critical [Ｊ]. Cancer Res, 2005; 65(20): 9377-9387.
26.	Deryugina EI, Soroceanu L, Strongin AY. Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis [Ｊ]. Cancer Res, 2002; 62(2): 580-588.
27.	Dean RA, Butler GS, Hamma-Kourbali Y, et al. Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis [Ｊ]. Mol Cell Biol, 2007; 27(24): 8454-8465.
28.	Hashimoto G, Inoki I, Fujii Y, et al. Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 [Ｊ]. J Biol Chem, 2002; 277(39): 36288-36295.
29.	Ito TK, Ishii G, Chiba H, et al. The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells [Ｊ]. Oncogene, 2007; 26(51): 7194-7203.
30.	Soff GA. Angiostatin and angiostatin-related proteins [Ｊ]. Cancer Metastasis Rev, 2000; 19(1-2): 97-107.
31.	Pozzi A, LeVine WF, Gardner HA. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis [Ｊ]. Oncogene, 2002; 21(2): 272-281.
32.	Jodele S, Blavier L, Yoon JM, et al. Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression [Ｊ]. Cancer Metastasis Rev, 2006; 25(1): 35-43.
33.	俞继卫, 姜波健. 胃癌浸润和转移中基质金属蛋白酶及其抑制剂的分子基础和临床价值 [Ｊ]. 腹部外科, 2007; 20(4): 245-247.

1. 张鹏, 俞继卫, 姜波健. 肿瘤干细胞与胃肠道癌发生和转移 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(1): 81-84.
2. Woessner JF Jr. MMPs and TIMPs－an historical perspective [Ｊ]. Mol Biotechnol, 2002; 22(1): 33-49.
3. McCawley LJ, Matrisian LM. Matrix metalloproteinases: th-ey’re not just for matrix anymore! [Ｊ]. Curr Opin Cell Biol, 2001; 13(5): 534-540.
4. Yu WH, Woessner JF Jr, McNeish JD, et al. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling [Ｊ]. Genes Dev, 2002; 16(3): 307-323.
5. Suzuki M, Raab G, Moses MA, et al. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site [Ｊ]. J Biol Chem, 1997; 272(50): 31730-31737.
6. Rauvala M, Aglund K, Puistola U, et al. Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression [Ｊ]. Int J Gynecol Cancer, 2006; 16(3): 1297-1302.
7. Tatti O, Vehvilinen P, Lehti K, et al. MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1 [Ｊ]. Exp Cell Res, 2008； 314(13): 2501-2514.
8. Puthawala K, Hadjiangelis N, Jacoby SC, et al. Inhibition of integrin αvβ6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis [Ｊ]. Am J Respir Crit Care Med, 2008; 177(1): 82-90.
9. Miyamoto S, Nakamura M, Yano K, et al. Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-Ⅱ via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix [Ｊ]. Cancer Sci, 2007; 98(5): 685-691.
10. Mysliwy J, Dingley AJ, Sedlacek R, et al. Structural characterization and binding properties of the hemopexin-like domain of the matrixmetalloproteinase-19 [Ｊ]. Protein Expr Purif, 2006; 46(2): 406-413.
11. Gennigens C, Menetrier-Caux C, Droz JP. Insulin-like gro-wth factor (IGF) family and prostate cancer [Ｊ]. Crit Rev Oncol Hematol, 2006; 58(2): 124-145.
12. Uttamsingh S, Bao X, Nguyen KT, et al. Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells [Ｊ]. Oncogene, 2008; 27(18): 2626-2634.
13. Kwabi-Addo B, Ozen M, Ittmann M. The role of fibroblast growth factors and their receptors in prostate cancer [Ｊ]. Endocr Relat Cancer, 2004; 11(4): 709-724.
14. Zheng H, Takahashi H, Murai Y, et al. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Anticancer Res, 2006; 26(5A): 3579-3583.
15. Zheng HC, Sun JM, Li XH, et al. Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma [Ｊ]. Pathol Int, 2003; 53(10): 659-666.
16. Yasui W, Oue N, Aung PP, et al. Molecular-pathological prognostic factors of gastric cancer: a review [Ｊ]. Gastric Cancer, 2005; 8(2): 86-94.
17. Elnemr A, Yonemura Y, Bandou E, et al. Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer [Ｊ]. Gastric Cancer, 2003; 6(1): 30-38.
18. 严冬, 沈琳, 吕尤勇. MMP-11在胃癌患者血清中的表达及临床意义 [Ｊ]. 中国癌症杂志, 2007; 17(12): 968-972.
19. Friedl P, Brcker EB. The biology of cell locomotion within three-dimensional extracellular matrix [Ｊ]. Cell Mol Life Sci, 2000; 57(1): 41-64.
20. Dittmar T, Heyder C, Gloria-Maercker E, et al. Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner [Ｊ]. Clin Exp Metastasis, 2008; 25(1): 11-32.
21. Hornebeck W, Emonard H, Maquart FX, et al. Proteolysis directed by the extracellular matrix [Ｊ]. J Soc Biol, 2003; 197(1): 25-30.
22. Przybylo JA, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail’s pace [Ｊ]. Int J Biochem Cell Biol, 2007; 39(6): 1082-1088.
23. 徐胜军, 胡炳奎, 凌志强, 等. CD44v6在胃癌中的表达及其临床意义 [Ｊ]. 中国普外基础与临床杂志, 2006; 13(1): 42-44.
24. Giannelli G, Falk-Marzillier J, Schiraldi O, et al. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5 [Ｊ]. Science, 1997; 277(5323): 225-228.
25. Nisato RE, Hosseini G, Sirrenberg C, et al. Dissecting the role of matrix metalloproteinases (MMP) and integrin αvβ3 in angiogenesis in vitro: absence of hemopexin C domain bioactivity, but membrane-type 1-MMP and αvβ3 are critical [Ｊ]. Cancer Res, 2005; 65(20): 9377-9387.
26. Deryugina EI, Soroceanu L, Strongin AY. Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis [Ｊ]. Cancer Res, 2002; 62(2): 580-588.
27. Dean RA, Butler GS, Hamma-Kourbali Y, et al. Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis [Ｊ]. Mol Cell Biol, 2007; 27(24): 8454-8465.
28. Hashimoto G, Inoki I, Fujii Y, et al. Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 [Ｊ]. J Biol Chem, 2002; 277(39): 36288-36295.
29. Ito TK, Ishii G, Chiba H, et al. The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells [Ｊ]. Oncogene, 2007; 26(51): 7194-7203.
30. Soff GA. Angiostatin and angiostatin-related proteins [Ｊ]. Cancer Metastasis Rev, 2000; 19(1-2): 97-107.
31. Pozzi A, LeVine WF, Gardner HA. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis [Ｊ]. Oncogene, 2002; 21(2): 272-281.
32. Jodele S, Blavier L, Yoon JM, et al. Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression [Ｊ]. Cancer Metastasis Rev, 2006; 25(1): 35-43.
33. 俞继卫, 姜波健. 胃癌浸润和转移中基质金属蛋白酶及其抑制剂的分子基础和临床价值 [Ｊ]. 腹部外科, 2007; 20(4): 245-247.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of Promoting Function of Matrix Metalloproteinases in Gastric Cancer via Regulating Microenvironment

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