Clinical Effect of Neo-Adjuvant Chemotherapy Combined with Operation for Colorectal Cancer Elderly Patients in Multi-Disciplinary Team_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiaodong ¹ , ZENG Tianfang ¹ , YANG Yanjiao ¹ , QIU Meng ² , LI Li ¹

1.Department of Anal-Colorectal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;;
2.Department of Oncology, West China Hospital, Sichuan University, Chengdu 610041, ChinaCorresponding Author： LI Li, E-mail： drlili116@126.com;

Corresponding author：

Keywords：

Multi-disciplinary team; Elderly patient; Colorectal cancer; Neo-adjuvant chemotherapy; Operation

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To discuss the safety and clinical differences among elderly people being treated with neo-adjuvant chemotherapy combined with operation.
Methods 　To analyze retrospectively the data of patients diagnosed definitely as colorectal cancer in West China Hospital of Sichuan University from June 2007 to December 2007, and to compare the clinical effect differences between elderly group (≥60 years) and non-elderly group ( lt;60 years) with combined therapy.
Results 　Among preoperative indexes, the constituent ratios of elderly group combined with cardiac vessels system diseases, endocrine system diseases or other system diseases were all obviously higher than those of non-elderly group, the differences showed statistical significance (P lt;0.05); Constituent ratio of elderly patients with hypertension or diabetes mellitus was also higher than that of non-elderly patients, there were still statistical significance (P lt;0.05), but no statistical significances among other preoperative indexes (P gt;0.05); Differences of indexes during operation between two groups showed no statistical significance (P gt;0.05). But during postoperative indexes, complications in elderly group were higher than those of non-elderly group, and the differences had statistical significance (P lt;0.05), and the time of removing gastric canal, urinary catheter and drainage tube between two groups showed no statistical significance (P gt;0.05); Meanwhile, the intake time, venting time and defecation time after operation and out-of-bed activity time after operation also had no statistical significance (P gt;0.05). As to the adverse effect relate to chemotherapy, there were no statistical significances (P gt;0.05).
Conclusion 　Elderly patients may have more poor physical condition and it maybe more difficult to treat them. In
spite of this, the comprehensive treatment of neo-adjuvant chemotherapy combined with surgical operation will not lead to the delay of surgical therapy, in addition, operating modus during surgical intervention will not be effected and its therapeutic effect in the near future was optimistic. So the application of this combined therapy has some clinical effects and would be safety.

Citation： WANG Xiaodong,ZENG Tianfang,YANG Yanjiao,QIU Meng,LI Li. Clinical Effect of Neo-Adjuvant Chemotherapy Combined with Operation for Colorectal Cancer Elderly Patients in Multi-Disciplinary Team. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(10): 773-777. doi: Copy

1.	Morris E, Haward RA, Gilthorpe MS, et al. The impact of the Calman-Hine report on the processes and outcomes of care for Yorkshire’s colorectal cancer patients [Ｊ]. Br J Cancer, 2006; 95(8)∶979.
2.	汪晓东, 曹霖, 罗德云, 等. 多学科协作诊治模式下运行结直肠癌综合治疗的临床对照研究 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(1)∶63.
3.	Kobayashi H, Mochizuki H, Sugihara K, et al. Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study [Ｊ]. Surgery, 2007; 141(1)∶67.
4.	Wedding U, Honecker F, Bokemeyer C, et al. Tolerance to chemotherapy in elderly patients with cancer [Ｊ]. Cancer Control, 2007; 14(1)∶44.
5.	方鹏骞, 陈茂盛. 人口老龄化的内涵界定及世界人口老龄化趋势 [Ｊ]. 国外医学·社会医学分册, 2001; 18(2)∶61.
6.	吕东昊, 汪晓东, 阳川华, 等. 结直肠肿瘤多学科协作诊治模式的数据库初期建设现状 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(6)∶713.
7.	Tassinari D, Montanari L, Maltoni M, et al. The palliative prognostic score and survival in patients with advanced solid tumors receiving chemotherapy [Ｊ]. Support Care Cancer, 2008; 16(4)∶359.
8.	Yii MK, Ng KJ. Risk-adjusted surgical audit with the POSSUM scoring system in a developing country. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity [Ｊ]. Br J Surg, 2002; 89(1)∶110.
9.	汪晓东, 冯硕, 游小林, 等. 结直肠肿瘤多学科协作诊治模式下的随访体系建设 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(6)∶709.
10.	汪晓东, 刘春娟, 陈增蓉, 等. 多学科协作诊治模式下新辅助化疗联合手术治疗结直肠癌患者的生存质量评估 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(5)∶371.
11.	Pacella CM, Valle D, Bizzarri G, et al. Percutaneous laser ablation in patients with isolated unresectable liver metastases from colorectal cancer: Results of a phase Ⅱ study [Ｊ]. Acta Oncol， 2006; 45(1)∶77.
12.	Ishikawa M, Nishioka M, Hanaki N, et al. Colorectal resection by a minilaparotomy approach vs. conventional operation for colon cancer. Results of a prospective randomized trial [Ｊ]. Hepatogastroenterology, 2007; 54(79)∶1970.
13.	汪晓东, 邱萌, 李亚伦, 等. 多学科协作诊治模式下结直肠癌不同周期新辅助化疗联合手术的方案研究 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(3)∶210.
14.	Gozalan U, Yasti AC, Yuksek YN, et al. Peritoneal cytology in colorectal cancer: incidence and prognostic value [Ｊ]. Am J Surg, 2007; 193(6)∶672.
15.	刘展, 汪晓东, 李立. 多学科协作诊治模式下的结直肠外科快速康复流程 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(2)∶239.
16.	Olin K, Eriksdotter-Jnhagen M, Jansson A, et al. Postoperative delirium in elderly patients after major abdominal surgery [Ｊ]. Br J Surg, 2005; 92(12)∶1559.

1. 　Morris E, Haward RA, Gilthorpe MS, et al. The impact of the Calman-Hine report on the processes and outcomes of care for Yorkshire’s colorectal cancer patients [Ｊ]. Br J Cancer, 2006; 95(8)∶979.
2. 　汪晓东, 曹霖, 罗德云, 等. 多学科协作诊治模式下运行结直肠癌综合治疗的临床对照研究 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(1)∶63.
3. 　Kobayashi H, Mochizuki H, Sugihara K, et al. Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study [Ｊ]. Surgery, 2007; 141(1)∶67.
4. 　Wedding U, Honecker F, Bokemeyer C, et al. Tolerance to chemotherapy in elderly patients with cancer [Ｊ]. Cancer Control, 2007; 14(1)∶44.
5. 　方鹏骞, 陈茂盛. 人口老龄化的内涵界定及世界人口老龄化趋势 [Ｊ]. 国外医学·社会医学分册, 2001; 18(2)∶61.
6. 　吕东昊, 汪晓东, 阳川华, 等. 结直肠肿瘤多学科协作诊治模式的数据库初期建设现状 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(6)∶713.
7. 　Tassinari D, Montanari L, Maltoni M, et al. The palliative prognostic score and survival in patients with advanced solid tumors receiving chemotherapy [Ｊ]. Support Care Cancer, 2008; 16(4)∶359.
8. 　Yii MK, Ng KJ. Risk-adjusted surgical audit with the POSSUM scoring system in a developing country. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity [Ｊ]. Br J Surg, 2002; 89(1)∶110.
9. 　汪晓东, 冯硕, 游小林, 等. 结直肠肿瘤多学科协作诊治模式下的随访体系建设 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(6)∶709.
10. 　汪晓东, 刘春娟, 陈增蓉, 等. 多学科协作诊治模式下新辅助化疗联合手术治疗结直肠癌患者的生存质量评估 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(5)∶371.
11. 　Pacella CM, Valle D, Bizzarri G, et al. Percutaneous laser ablation in patients with isolated unresectable liver metastases from colorectal cancer: Results of a phase Ⅱ study [Ｊ]. Acta Oncol， 2006; 45(1)∶77.
12. 　Ishikawa M, Nishioka M, Hanaki N, et al. Colorectal resection by a minilaparotomy approach vs. conventional operation for colon cancer. Results of a prospective randomized trial [Ｊ]. Hepatogastroenterology, 2007; 54(79)∶1970.
13. 　汪晓东, 邱萌, 李亚伦, 等. 多学科协作诊治模式下结直肠癌不同周期新辅助化疗联合手术的方案研究 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(3)∶210.
14. 　Gozalan U, Yasti AC, Yuksek YN, et al. Peritoneal cytology in colorectal cancer: incidence and prognostic value [Ｊ]. Am J Surg, 2007; 193(6)∶672.
15. 　刘展, 汪晓东, 李立. 多学科协作诊治模式下的结直肠外科快速康复流程 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(2)∶239.
16. 　Olin K, Eriksdotter-Jnhagen M, Jansson A, et al. Postoperative delirium in elderly patients after major abdominal surgery [Ｊ]. Br J Surg, 2005; 92(12)∶1559.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Effect of Neo-Adjuvant Chemotherapy Combined with Operation for Colorectal Cancer Elderly Patients in Multi-Disciplinary Team

Abstract Full text Figures/Tables Video References Cited by

Format

Content