Research Advancement of Hepatic Ischemic Preconditioning_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YE Bogen , GENG Xiaoping

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;

Corresponding author：

Keywords：

Ischemic preconditioning; Hepatectomy; Liver transplantation; Ischemia-reperfusion injury

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo summarize recent researches on mechanism of the hepatic ischemic preconditioning (IPC) and its clinical applications on hepatectomy and liver transplantation. MethodsRelevant references about basic and clinical researches of hepatic IPC were collected and reviewed. ResultsRecent experimental researches indicated that IPC could relieve hepatic ischemiareperfusion injury (IRI) by remaining and improving energy metabolism of liver, regulating microcirculation disorder, decreasing the production of lipid peroxidation and oxyradical. It could also inhibit the activation of inflammatory cells and the release of cytokine, suppress cell apoptosis and induce the release of endogenous protective substance. Till now, most of the clinical researches had confirmed the protective function of hepatic IPC, but there were still some references with opposite opinions. ConclusionHepatic IPC could relieve liver IRI, but its clinical application value on hepatectomy and liver transplantation still need more researches to prove.

Citation： YE Bogen,GENG Xiaoping. Research Advancement of Hepatic Ischemic Preconditioning. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(4): 303-306. doi: Copy

1.	Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium [J]. Circulation, 1986; 74(5)∶1124.
2.	Dehni N, Chazouilleres O, Vaubourdolle M, et al. Does the preconditioning effect work in normothermic liver ischemia? A study of the isolated perfused rat liver [J]. Hepatology, 1994; 20(2)∶394.
3.	Riksen NP, Smits P, Rongen GA. Ischaemic preconditioning: from molecular characterisation to clinical application——part Ⅰ [J]. Neth J Med, 2004; 62(10)∶353.
4.	Jaeschke H. Molecular mechanisms of hepatic ischemiareperfusion injury and preconditioning [J]. Am J Physiol Gastrointest Liver Physiol， 2003; 284(1)∶G15.
5.	Kerem M, Bedirli A, Ofluoglu E, et al. Ischemic preconditioning improves liver regeneration by sustaining energy metabolism after partial hepatectomy under ischemia in rats [J]. Liver Int， 2006; 26(8)∶994.
6.	Clavien PA, Selzner M, Rüdiger HA, et al. A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning [J]. Ann Surg， 2003; 238(6)∶843.
7.	Sakamoto N, Sun Z, Brengman ML, et al. Hepatic reticuloendothelial system dysfunction after ischemiareperfusion: role of Pselectinmediated neutrophil accumulation [J]. Liver Transpl， 2003; 9(9)∶940.
8.	Peralta C, Fernández L, Panés J, et al. Preconditioning protects against systemic disorders associated with hepatic ischemiareperfusion through blockade of tumor necrosis factorinduced Pselectin upregulation in the rat [J]. Hepatology， 2001; 33(1)∶100.
9.	Caban A, Oczkowicz G, AbdelSamad O, et al. Influence of ischemic preconditioning and nitric oxide on microcirculation and the degree of rat liver injury in the model of ischemia and reperfusion [J]. Transplant Proc， 2006; 38(1)∶196.
10.	Tejima K, Arai M, Ikeda H, et al. Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats [J]. Gastroenterology， 2004; 127(5)∶1488.
11.	Serafín A, RosellóCatafau J, Prats N, et al. Ischemic preconditioning affects interleukin release in fatty livers of rats undergoing ischemia/reperfusion [J]. Hepatology， 2004; 39(3)∶688.
12.	Cheng XD, Jiang XC, Liu YB, et al. Effect of ischemic preconditioning on Pselectin expression in hepatocytes of rats with cirrhotic ischemiareperfusion injury [J]. World J Gastroenterol， 2003; 9(10)∶2289.
13.	Quireze C, Montero EF, Leito RM, et al. Ischemic preconditioning prevents apoptotic cell death and necrosis in early and intermediate phases of liver ischemiareperfusion injury in rats [J]. J Invest Surg， 2006; 19(4)∶229.
14.	Sun K, Liu ZS, Sun Q. Role of mitochondria in cell apoptosis during hepatic ischemiareperfusion injury and protective effect of ischemic postconditioning [J]. World J Gastroenterol， 2004; 10(13)∶1934.
15.	马跃峰 , 李相成, 姚爱华，等. 缺血预处理对大鼠肝脏移植物再灌注早期NFκB活性的影响及意义 [J]. 中国普外基础与临床杂志, 2006; 13(5)∶531.
16.	Mallick IH, Yang W, Winslet MC, et al. Protective effects of ischemic preconditioning on the intestinal mucosal microcirculation following ischemiareperfusion of the intestine [J]. Microcirculation， 2005; 12(8)∶615.
17.	王科，王学浩，张峰，等. 诱导HO1改善氧化应激状态减轻老年供肝缺血再灌注损伤 [J]. 中国普外基础与临床杂志, 2005; 12(2)∶109.
18.	Xiao JS, Cai FG, Niu Y, et al. Preconditioning effects on expression of protooncogenes cfos and cjun after hepatic ischemia/reperfusion in rats [J]. Hepatobiliary Pancreat Dis Int， 2005; 4(2)∶197.
19.	Cai FG, Xiao JS, Ye QF. Effects of ischemic preconditioning on cyclinD1 expression during early ischemic reperfusion in rats [J]. World J Gastroenterol， 2006; 12(18)∶2936.
20.	Clavien PA, Yadav S, Sindram D, et al. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans [J]. Ann Surg， 2000; 232(2)∶155.
21.	Nuzzo G, Giuliante F, Vellone M, et al. Pedicle clamping with ischemic preconditioning in liver resection [J]. Liver Transpl， 2004; 10(2 Suppl 1)∶S53.
22.	梁力建，李绍强，黄洁夫. 缺血预处理对肝硬化肝癌患者入肝血流阻断肝切除的保护作用及其机理探讨 [J]. 中华外科杂志, 2002; 40(4)∶265.
23.	Li SQ, Liang LJ, Huang JF, et al. Ischemic preconditioning protects liver from hepatectomy under hepatic inflow occlusion for hepatocellular carcinoma patients with cirrhosis [J]. World J Gastroenterol， 2004; 10(17)∶2580.
24.	Azoulay D, Lucidi V, Andreani P, et al. Ischemic preconditioning for major liver resection under vascular exclusion of the liver preserving the caval flow: a randomized prospective study [J]. J Am Coll Surg， 2006; 202(2)∶203.
25.	秦嵩, 孙备, 许军, 等. 缺血预处理对大鼠肝脏低温保存损伤的保护作用 [J]. 中国普外基础与临床杂志, 2003; 10(4)∶323.
26.	Compagnon P, Lindell S, Ametani MS, et al. Ischemic preconditioning and liver tolerance to warm or cold ischemia: experimental studies in large animals [J]. Transplantation， 2005; 79(10)∶1393.
27.	Niemann CU, Hirose R, Liu T, et al. Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers [J]. Anesth Analg， 2005; 101(6)∶1577.
28.	Azoulay D, Del Gaudio M, Andreani P, et al. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft’s preservation and function: the ying and the yang [J]. Ann Surg， 2005; 242(1)∶133.
29.	Koneru B, Fisher A, He Y, et al. Ischemic preconditioning in deceased donor liver transplantation: a prospective randomized clinical trial of safety and efficacy [J]. Liver Transpl， 2005; 11(2)∶196.
30.	Cescon M, Grazi GL, Grassi A, et al. Effect of ischemic preconditioning in whole liver transplantation from deceased donors. A pilot study [J]. Liver Transpl， 2006; 12(4)∶628.
31.	Kadono J, Hamada N, Fukueda M, et al. Advantage of ischemic preconditioning for hepatic resection in pigs [J]. J Surg Res， 2006; 134(2)∶173.
32.	Rüdiger HA, Kang KJ, Sindram D, et al. Comparison of ischemic preconditioning and intermittent and continuous inflow occlusion in the murine liver [J]. Ann Surg， 2002; 235(3)∶400.
33.	Petrowsky H, McCormack L, Trujillo M, et al. A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection [J]. Ann Surg， 2006; 244(6)∶921.
34.	Smyrniotis V, Kostopanagiotou G, Theodoraki K, et al. Ischemic preconditioning versus intermittent vascular inflow control during major liver resection in pigs [J]. World J Surg， 2005; 29(7)∶930.
35.	Eipel C, Glanemann M, Nuessler AK, et al. Ischemic preconditioning impairs liver regeneration in extended reducedsize livers [J]. Ann Surg， 2005; 241(3)∶477.

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium [J]. Circulation, 1986; 74(5)∶1124.
2. Dehni N, Chazouilleres O, Vaubourdolle M, et al. Does the preconditioning effect work in normothermic liver ischemia? A study of the isolated perfused rat liver [J]. Hepatology, 1994; 20(2)∶394.
3. Riksen NP, Smits P, Rongen GA. Ischaemic preconditioning: from molecular characterisation to clinical application——part Ⅰ [J]. Neth J Med, 2004; 62(10)∶353.
4. Jaeschke H. Molecular mechanisms of hepatic ischemiareperfusion injury and preconditioning [J]. Am J Physiol Gastrointest Liver Physiol， 2003; 284(1)∶G15.
5. Kerem M, Bedirli A, Ofluoglu E, et al. Ischemic preconditioning improves liver regeneration by sustaining energy metabolism after partial hepatectomy under ischemia in rats [J]. Liver Int， 2006; 26(8)∶994.
6. Clavien PA, Selzner M, Rüdiger HA, et al. A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning [J]. Ann Surg， 2003; 238(6)∶843.
7. Sakamoto N, Sun Z, Brengman ML, et al. Hepatic reticuloendothelial system dysfunction after ischemiareperfusion: role of Pselectinmediated neutrophil accumulation [J]. Liver Transpl， 2003; 9(9)∶940.
8. Peralta C, Fernández L, Panés J, et al. Preconditioning protects against systemic disorders associated with hepatic ischemiareperfusion through blockade of tumor necrosis factorinduced Pselectin upregulation in the rat [J]. Hepatology， 2001; 33(1)∶100.
9. Caban A, Oczkowicz G, AbdelSamad O, et al. Influence of ischemic preconditioning and nitric oxide on microcirculation and the degree of rat liver injury in the model of ischemia and reperfusion [J]. Transplant Proc， 2006; 38(1)∶196.
10. Tejima K, Arai M, Ikeda H, et al. Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats [J]. Gastroenterology， 2004; 127(5)∶1488.
11. Serafín A, RosellóCatafau J, Prats N, et al. Ischemic preconditioning affects interleukin release in fatty livers of rats undergoing ischemia/reperfusion [J]. Hepatology， 2004; 39(3)∶688.
12. Cheng XD, Jiang XC, Liu YB, et al. Effect of ischemic preconditioning on Pselectin expression in hepatocytes of rats with cirrhotic ischemiareperfusion injury [J]. World J Gastroenterol， 2003; 9(10)∶2289.
13. Quireze C, Montero EF, Leito RM, et al. Ischemic preconditioning prevents apoptotic cell death and necrosis in early and intermediate phases of liver ischemiareperfusion injury in rats [J]. J Invest Surg， 2006; 19(4)∶229.
14. Sun K, Liu ZS, Sun Q. Role of mitochondria in cell apoptosis during hepatic ischemiareperfusion injury and protective effect of ischemic postconditioning [J]. World J Gastroenterol， 2004; 10(13)∶1934.
15. 马跃峰 , 李相成, 姚爱华，等. 缺血预处理对大鼠肝脏移植物再灌注早期NFκB活性的影响及意义 [J]. 中国普外基础与临床杂志, 2006; 13(5)∶531.
16. Mallick IH, Yang W, Winslet MC, et al. Protective effects of ischemic preconditioning on the intestinal mucosal microcirculation following ischemiareperfusion of the intestine [J]. Microcirculation， 2005; 12(8)∶615.
17. 王科，王学浩，张峰，等. 诱导HO1改善氧化应激状态减轻老年供肝缺血再灌注损伤 [J]. 中国普外基础与临床杂志, 2005; 12(2)∶109.
18. Xiao JS, Cai FG, Niu Y, et al. Preconditioning effects on expression of protooncogenes cfos and cjun after hepatic ischemia/reperfusion in rats [J]. Hepatobiliary Pancreat Dis Int， 2005; 4(2)∶197.
19. Cai FG, Xiao JS, Ye QF. Effects of ischemic preconditioning on cyclinD1 expression during early ischemic reperfusion in rats [J]. World J Gastroenterol， 2006; 12(18)∶2936.
20. Clavien PA, Yadav S, Sindram D, et al. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans [J]. Ann Surg， 2000; 232(2)∶155.
21. Nuzzo G, Giuliante F, Vellone M, et al. Pedicle clamping with ischemic preconditioning in liver resection [J]. Liver Transpl， 2004; 10(2 Suppl 1)∶S53.
22. 梁力建，李绍强，黄洁夫. 缺血预处理对肝硬化肝癌患者入肝血流阻断肝切除的保护作用及其机理探讨 [J]. 中华外科杂志, 2002; 40(4)∶265.
23. Li SQ, Liang LJ, Huang JF, et al. Ischemic preconditioning protects liver from hepatectomy under hepatic inflow occlusion for hepatocellular carcinoma patients with cirrhosis [J]. World J Gastroenterol， 2004; 10(17)∶2580.
24. Azoulay D, Lucidi V, Andreani P, et al. Ischemic preconditioning for major liver resection under vascular exclusion of the liver preserving the caval flow: a randomized prospective study [J]. J Am Coll Surg， 2006; 202(2)∶203.
25. 秦嵩, 孙备, 许军, 等. 缺血预处理对大鼠肝脏低温保存损伤的保护作用 [J]. 中国普外基础与临床杂志, 2003; 10(4)∶323.
26. Compagnon P, Lindell S, Ametani MS, et al. Ischemic preconditioning and liver tolerance to warm or cold ischemia: experimental studies in large animals [J]. Transplantation， 2005; 79(10)∶1393.
27. Niemann CU, Hirose R, Liu T, et al. Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers [J]. Anesth Analg， 2005; 101(6)∶1577.
28. Azoulay D, Del Gaudio M, Andreani P, et al. Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft’s preservation and function: the ying and the yang [J]. Ann Surg， 2005; 242(1)∶133.
29. Koneru B, Fisher A, He Y, et al. Ischemic preconditioning in deceased donor liver transplantation: a prospective randomized clinical trial of safety and efficacy [J]. Liver Transpl， 2005; 11(2)∶196.
30. Cescon M, Grazi GL, Grassi A, et al. Effect of ischemic preconditioning in whole liver transplantation from deceased donors. A pilot study [J]. Liver Transpl， 2006; 12(4)∶628.
31. Kadono J, Hamada N, Fukueda M, et al. Advantage of ischemic preconditioning for hepatic resection in pigs [J]. J Surg Res， 2006; 134(2)∶173.
32. Rüdiger HA, Kang KJ, Sindram D, et al. Comparison of ischemic preconditioning and intermittent and continuous inflow occlusion in the murine liver [J]. Ann Surg， 2002; 235(3)∶400.
33. Petrowsky H, McCormack L, Trujillo M, et al. A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection [J]. Ann Surg， 2006; 244(6)∶921.
34. Smyrniotis V, Kostopanagiotou G, Theodoraki K, et al. Ischemic preconditioning versus intermittent vascular inflow control during major liver resection in pigs [J]. World J Surg， 2005; 29(7)∶930.
35. Eipel C, Glanemann M, Nuessler AK, et al. Ischemic preconditioning impairs liver regeneration in extended reducedsize livers [J]. Ann Surg， 2005; 241(3)∶477.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Advancement of Hepatic Ischemic Preconditioning

Abstract Full text Figures/Tables Video References Cited by

Format

Content