Objective To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in treating primary hepatocellular carcinoma (HCC).
Methods From March 2004 to March 2006, 137 patients with primary HCC underwent TACE alone (n=87) and TACE+RFA (n=50), respectively, after the interventional treatment, all patients periodically received CT reexaminations and alpha fetoprotein (AFP) measurement. The therapeutic efficacy, AFP level and survival rate between two groups were compared with each other.
Results In TACE group the effective rate (CR+PR) was 34.5%, AFP decreasing amplitude was 54.2%, and 2 years survival rate was 43.7%. While in TACE+RFA group, the effective rate (CR+PR) was 70.0%, AFP decreasing amplitude was 78.0%, and 2 years survival rate was 62.0%, there were significant differences between two groups (P＜0.05).
Conclusion Combined application of TACE and RFA is significantly superior to TACE alone in treatment of primary HCC.
Citation：
QIAN Zhiling,CUI Shichang,WANG Haiyan.. Clinical Study on Efficacy of Transcatheter Arterial Chemoembolization Combined with Radiofrequency Ablation in Treating Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(9): 686-689. doi:
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- 1. 孙燕， 周际昌主编. 临床肿瘤内科手册 [M]. 第4版. 北京: 人民卫生出版社， 2003∶106~107.
- 2. 王建华. 肝癌的介入治疗 [Ｊ]. 中华肝脏病杂志， 1998; 6(3)∶175.
- 3. Nonami T, Isshiki K, Katoh H, et al.The potential role of postoperative hepatic artery chemotherapy in patients with high-risk hepatomas [Ｊ]. Ann Surg, 1991; 213(3)∶222.
- 4. Tanaka K, Nakamura S, Numata K, et al. Hepatocellular carcinoma: treatment with percutaneous ethanol injection and transcatheter arterial embolization [Ｊ]. Radiology, 1992; 185(2)∶457.
- 5. 周国雄， 成建萍， 黄介飞， 等. TAE、PVE、PEI 序贯介入治疗晚期原发性肝癌的临床研究 [Ｊ] . 中华肿瘤杂志， 1998; 20(4)∶312.
- 6. 蔡茂杯， 夏月琴， 刘菊林. 肝动脉加腹腔双重灌注治疗晚期肝癌的初步研究 [Ｊ]. 中国现代医学杂志， 2000； 10(1)∶24.
- 7. Koda M, Ueki M, Maeda Y, et al. Percutaneous sonographically guided radiofrequency ablation with artificial pleural effusion for hepatocellular carcinoma located under the diaphragm [Ｊ]. AJR Am J Roentgenol， 2004; 183(3)∶583.
- 8. 张智坚. 肝癌的射频消融治疗 [Ｊ]. 中国实用外科杂志, 2004； 24(8)∶ 465.
- 9. 平定, 苗毅. 肝脏肿瘤射频灭活的研究进展 [Ｊ]. 肝胆外科杂志, 2003； 11(3)∶235.
- 10. 杨薇, 陈敏华, 严昆, 等. 射频消融对较大肝肿瘤治疗范围与布针方案计算的研究 [Ｊ]. 中华超声影像学杂志, 2002; 11(4)∶244.
- 11. 朱一宁, 阎文, 庞志东, 等. 经皮射频消融治疗肝癌的临床研究 [Ｊ]. 肝胆外科杂志, 2002; 10(3)∶178.
- 12. 范卫君, 赵明, 吴沛宏, 等. 经皮射频消融术在肝脏肿瘤治疗中的临床价值 [Ｊ]. 中华放射学杂志, 2002; 36(4)∶313.
- 13. 吴沛宏, 张福君. 原发性肝癌介入治疗基本模式的转变——经动脉导管栓塞化疗序贯联合消融治疗 [Ｊ]. 中华放射学杂志, 2003; 37(10)∶870.
- 14. 张智坚, 吴孟超, 陈汉, 等. 经皮肝穿刺射频热凝与肝动脉化疗栓塞联合治疗肝细胞癌 [Ｊ]. 中华外科杂志, 2002; 40(11)∶826.
- 15. 王吉耀主编. 内科学 [M]. 第1版. 北京: 人民卫生出版社, 2002∶502~509.
