Syndecan-1 Protein Expression in Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FENG Yunlu ¹ , XIAO Yi ² , QIAN Jiaming ¹ , CHEN Yuanjia ¹ , LIN Guole ² , WU Bin ² , QIU Huizhong ²

Department of Digestive Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China;

Corresponding author：

Keywords：

Syndecan-1; Colorectal cancer; Prognosis

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Objective 　Heparan sulfate proteoglycans (HSPGs) is an important component of the extracellular matrix. syndecan-1, a member of syndecan family, belongs to HSPGs and plays an important role in cell morphology and intracellular arrangement. The present study was designed to investigate the expression of syndecan-1 in patients with colorectal cancer, to analyse its relationship to cancer progression and clinical prognosis.
Methods 　Paraffin-embeded specimens were collected from 31 patients with colorectal cancers from 2003 to 2004 in Peking Union Medical College Hospital. Syndecan-1 protein expression was measured by immunohistochemistry. Its expression was evaluated with relationship to clinicopathological factors, including tumor infiltration, tumor differentiation, lymph node metastasis, accompanying with colorectal adenoma and 2-year survivals.
Results 　Immunohistochemistry in 31 specimens showed syndecan-1 were detected positive in 1 colorectal cancer tissue (3.2%), while positive in 29 normal tissues (93.5%), with significant difference (P＜0.01). No prognostic differences could be found in the clinic outcome because of the high expression rate of syndecan-1 in normal tissues and low expression rate in cancer tissues.
Conclusion 　Syncecan-1 is expressed in normal colorectal tissues and rarely expressed in cancer tissues.

Citation： FENG Yunlu,XIAO Yi,QIAN Jiaming,CHEN Yuanjia,LIN Guole,WU Bin,QIU Huizhong. Syndecan-1 Protein Expression in Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(3): 320-323. doi: Copy

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12.	茹国庆，赵仲生，汤琪乐，等. Syndecan-1和乙酰肝素酶mRNA表达与胃癌转移和预后的关系 [J]. 中华外科杂志， 2006; 44(15)∶1062.
13.	Day RM, Hao X, Ilyas M, et al. Changes in the expression of syndecan-1 in the colorectal adenoma-carcinoma sequence [J]. Virchows Arch， 1999; 434(2)∶121.
14.	Fujiya M, Watari J, Ashida T, et al. Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer [J]. Jpn J Cancer Res， 2001; 92(10)∶1074.
15.	Wiksten JP, Lundin J, Nordling S, et al. A prognostic value of syndecan-1 in gastric cancer [J]. Anticancer Res， 2000; 20(6D)∶4905.

1. Day RM, Hao X, Ilyas M, et al.Changes in the expression of syndecan-1 in the colorectal adenoma-carcinoma sequence [J]. Virchows Arch， 1999; 434(2)∶121.
2. Conejo JR, Kleeff J, Koliopanos A, et al. Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers [J]. Int J Cancer， 2000; 88(1)∶12.
3. 王学浩，成峰，钱建民，等. syndecan-1蛋白的表达与肝细胞肝癌恶性表型的研究 [J]. 中国普外基础与临床杂志， 2001； 8（4）∶239.
4. Greene FL, Page DL, Fleming ID, et al Eds. AJCC Cancer Staging Manual [M]. 6th Ed. New York: Springer, 2002∶113~119.
5. Mikami S, Ohashi K, Usui Y, et al. Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas [J]. Jpn J Cancer Res， 2001; 92(10)∶1062.
6. Beauvais DM, Rapraeger AC. Syndecans in tumor cell adhesion and signaling [J]. Reprod Biol Endocrinol， 2004; 2∶3.
7. Pulkkinen JO, Penttinen M, Jalkanen M, et al. Syndecan-1: a new prognostic marker in laryngeal cancer [J]. Acta Otolaryngol， 1997; 117(2)∶312.
8. Wiksten JP, Lundin J, Nordling S, et al. Epithelial and stromal syndecan-1 expression as predictor of outcome in patients with gastric cancer [J]. Int J Cancer， 2001; 95(1)∶1.
9. Joensuu H, Anttonen A, Eriksson M, et al. Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer [J]. Cancer Res， 2002; 62(18)∶5210.
10. Lundin M, Nordling S, Lundin J, et al. Epithelial syndecan-1 expression is associated with stage and grade in colorectal cancer [J]. Oncology， 2005; 68(4-6)∶306.
11. Langford JK, Yang Y, Kieber-Emmons T, et al. Identification of an invasion regulatory domain within the core protein of syndecan-1 [J]. J Biol Chem， 2005; 280(5)∶3467.
12. 茹国庆，赵仲生，汤琪乐，等. Syndecan-1和乙酰肝素酶mRNA表达与胃癌转移和预后的关系 [J]. 中华外科杂志， 2006; 44(15)∶1062.
13. Day RM, Hao X, Ilyas M, et al. Changes in the expression of syndecan-1 in the colorectal adenoma-carcinoma sequence [J]. Virchows Arch， 1999; 434(2)∶121.
14. Fujiya M, Watari J, Ashida T, et al. Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer [J]. Jpn J Cancer Res， 2001; 92(10)∶1074.
15. Wiksten JP, Lundin J, Nordling S, et al. A prognostic value of syndecan-1 in gastric cancer [J]. Anticancer Res， 2000; 20(6D)∶4905.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Syndecan-1 Protein Expression in Colorectal Cancer

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