Relationship Between Angiopoietin and Angiogenesis of Gastric Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Hua , CHEN Zhixin

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Gastric carcinoma; Angiopoietin; Angiogenesis

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Objective 　To study the relationship between angiopoietin and the angiogenesis of gastric carcinoma, and to investigate the inter-regulation effect between different vascular growth factors which exist in microenvironment of gastric carcinoma.
Methods 　Literatures about angiopoietin and angiogenesis of gastric carcinoma were collected and reviewed.
Results 　There is a relationship between the expression of angiopoietin in microcirculation and the angiogenesis of gastric carcinoma. Yet, it is still a disputable issue on the inter-regulation effect of different vascular growth factors.
Conclusion 　Angiopoietin may play an important role in the processes of sprouting, development and apoptosis of the microvessel of gastric carcinoma.

Citation： YANG Hua,CHEN Zhixin. Relationship Between Angiopoietin and Angiogenesis of Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(3): 368-370. doi: Copy

1.	Folkman J. Tumor angiogenesis: therapeutic implications [J]. N Engl J Med, 1971; 285(21)∶1182.
2.	Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [J]. Cell， 1996; 87(7)∶1171.
3.	Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis [J]. Science， 1997; 277(5322)∶55.
4.	Sato TN, Qin Y, Kozak CA, et al. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system [J]. Proc Natl Acad Sci USA， 1993; 90(20)∶9355.
5.	Fiedler U, Krissl T, Koidl S, et al. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats [J]. J Biol Chem， 2003; 278(3)∶1721.
6.	Sato TN, Tozawa Y, Deutsch U, et al.Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation [J]. Nature， 1995; 376(6535)∶70.
7.	孙秀菊, 付浩, 郑志红，等. Ang2基因表达与胃癌发生发展的关系 [J]. 中国肿瘤临床， 2003； 30（8）∶536.
8.	Etoh T, Inoue H, Tanaka S, et al. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases [J]. Cancer Res， 2001; 61(5)∶2145.
9.	张宁，陶凯雄，王国斌，等. 环氧合酶-2及血管生成素-2在大肠癌中的表达及临床意义 [J]. 中国普外基础与临床杂志， 2006； 13（5）∶564.
10.	Du JR, Jiang Y, Zhang YM, et al. Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas [J]. World J Gastroenterol， 2003; 9(7)∶1604.
11.	Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’Kinase/Akt signal transduction pathway [J].Circ Res， 2000; 86(1)∶24.
12.	Fujikawa K, de Aos Scherpenseel I, Jain SK, et al. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells [J]. Exp Cell Res， 1999; 253(2)∶663.
13.	Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem， 2000; 275(13)∶9102.
14.	DeBusk LM, Hallahan DE, Lin PC. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway [J].Exp Cell Res， 2004; 298(1)∶167.
15.	Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2 [J]. Proc Natl Acad Sci USA， 1998; 95(15)∶8829.
16.	Siemeister G, Schirner M, Weindel K, et al. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway [J]. Cancer Res， 1999; 59(13)∶3185.
17.	罗彦，文艳君，田聆，等. 鸡tie-2受体胞外片段重组蛋白的制备及其抗血管生成作用的研究 [J]. 中华医学遗传学杂志， 2004； 21（2）∶101.
18.	罗彦，田聆，吴扬，等. 鸡Tie-2受体胞外片段的原核表达及目的蛋白免疫原性的研究 [J]. 四川大学学报（医学版）， 2004； 35（2）∶154.
19.	王天宝，李兆亭. 血管内皮生长因子及微血管密度与胃癌进展的关系 [J]. 中国普外基础与临床杂志， 2002； 9（3）∶159.

1. Folkman J. Tumor angiogenesis: therapeutic implications [J]. N Engl J Med, 1971; 285(21)∶1182.
2. Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [J]. Cell， 1996; 87(7)∶1171.
3. Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis [J]. Science， 1997; 277(5322)∶55.
4. Sato TN, Qin Y, Kozak CA, et al. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system [J]. Proc Natl Acad Sci USA， 1993; 90(20)∶9355.
5. Fiedler U, Krissl T, Koidl S, et al. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats [J]. J Biol Chem， 2003; 278(3)∶1721.
6. Sato TN, Tozawa Y, Deutsch U, et al.Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation [J]. Nature， 1995; 376(6535)∶70.
7. 孙秀菊, 付浩, 郑志红，等. Ang2基因表达与胃癌发生发展的关系 [J]. 中国肿瘤临床， 2003； 30（8）∶536.
8. Etoh T, Inoue H, Tanaka S, et al. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases [J]. Cancer Res， 2001; 61(5)∶2145.
9. 张宁，陶凯雄，王国斌，等. 环氧合酶-2及血管生成素-2在大肠癌中的表达及临床意义 [J]. 中国普外基础与临床杂志， 2006； 13（5）∶564.
10. Du JR, Jiang Y, Zhang YM, et al. Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas [J]. World J Gastroenterol， 2003; 9(7)∶1604.
11. Kim I, Kim HG, So JN, et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3’Kinase/Akt signal transduction pathway [J].Circ Res， 2000; 86(1)∶24.
12. Fujikawa K, de Aos Scherpenseel I, Jain SK, et al. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells [J]. Exp Cell Res， 1999; 253(2)∶663.
13. Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem， 2000; 275(13)∶9102.
14. DeBusk LM, Hallahan DE, Lin PC. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway [J].Exp Cell Res， 2004; 298(1)∶167.
15. Lin P, Buxton JA, Acheson A, et al. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2 [J]. Proc Natl Acad Sci USA， 1998; 95(15)∶8829.
16. Siemeister G, Schirner M, Weindel K, et al. Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway [J]. Cancer Res， 1999; 59(13)∶3185.
17. 罗彦，文艳君，田聆，等. 鸡tie-2受体胞外片段重组蛋白的制备及其抗血管生成作用的研究 [J]. 中华医学遗传学杂志， 2004； 21（2）∶101.
18. 罗彦，田聆，吴扬，等. 鸡Tie-2受体胞外片段的原核表达及目的蛋白免疫原性的研究 [J]. 四川大学学报（医学版）， 2004； 35（2）∶154.
19. 王天宝，李兆亭. 血管内皮生长因子及微血管密度与胃癌进展的关系 [J]. 中国普外基础与临床杂志， 2002； 9（3）∶159.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Angiopoietin and Angiogenesis of Gastric Carcinoma

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