Clinicopathologic Features,Diagnosis and Treatment of Pancreatic Cystadenoma and Cystadenocarcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

魏志新 ¹ , 赵博 ² , 沙元革 ¹ , 赵瑞平 ³

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Keywords：

胰腺肿瘤; 囊腺瘤; 囊腺癌; 病理; 临床; 外科手术

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目的　探讨胰腺囊腺瘤和囊腺癌的临床病理特点及其诊治。
方法　回顾性分析山东省菏泽市立医院及曹县人民医院1996年6月至2007年3月共收治的17例患者的临床病理资料。
结果　本病临床表现无特征性。B超和CT检查能发现囊肿但不能确定类型。浆液性囊腺瘤7例均行肿瘤局部切除；黏液性囊腺瘤6例，行胰十二指肠切除1例，胰体尾切除5例；囊腺癌4例，行胰十二指肠切除加淋巴结清扫1例，胰体尾切除术2例，胰体尾加脾切除1例。光镜下浆液性囊腺瘤囊壁由扁平或立方上皮细胞组成；黏液性囊腺瘤囊壁由高柱状上皮细胞组成，可见乳头状突起；囊腺癌囊壁细胞核异形明显，可见核分裂象及间质浸润。15例获得B超随访，中位随访时间为42个月（1～129个月），除1例行胰体尾切除加脾切除的老年囊腺癌患者术后6个月死于营养衰竭和 1例胰十二指肠切除患者并发糖尿病外，其余患者生存满意，未见肿瘤复发。
结论　B超和CT是本病的主要影像检查方法。加强对本病临床病理特征的认识是提高诊治率的关键。手术切除治疗本病疗效满意。

Citation： 魏志新,赵博,沙元革,赵瑞平. Clinicopathologic Features,Diagnosis and Treatment of Pancreatic Cystadenoma and Cystadenocarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(4): 467-468. doi: Copy

1.	Femandez-del Castillo C, Targarona J, Thayer SP, et al. Incidental pancreas cysts: clinicopathologic characteristics and comparison with symptomatic patiients [Ｊ]. Arch Surg, 2003; 138(4)∶427.
2.	王单松，靳大勇，楼文晖，等. 胰腺囊腺瘤和囊腺癌的诊断及外科治疗 [Ｊ]. 中华普通外科杂志， 2007； 22（1）∶55.
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4.	吴泓，熊先泽，程南生，等. 胰腺囊腺癌的诊断（附36例报告） [Ｊ]. 中国普外基础与临床杂志， 2005； 12（5）∶509.
5.	Warshaw AL, Compton CC, Lewandrowski K, et al. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients [Ｊ]. Ann Surg, 1990; 212(4)∶432.
6.	魏志新，宝荣，孙智勇，等. 胰腺实性假乳头状瘤的病理特点及诊治体会 [Ｊ]. 中华普通外科杂志， 2007； 22（2）∶96.
7.	Brugge WR, Lauwers GY, Sahani D, et al. Cystic neoplasms of the pancreas [Ｊ]. N Engl J Med, 2004; 351(12)∶1218.
8.	Jimenez RE, Warshaw AL, Z’graggen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy [Ｊ]. Ann Surg, 1999; 230(4)∶501.
9.	Sarr MG, Carpenter HA, Prabhakar LP, et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? [Ｊ]. Ann Surg, 2000; 231(2)∶205.
10.	Bassi C, Salvia R, Molinari E, et al. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? [Ｊ]. World J Surg, 2003; 27(3)∶319.

1. 　Femandez-del Castillo C, Targarona J, Thayer SP, et al. Incidental pancreas cysts: clinicopathologic characteristics and comparison with symptomatic patiients [Ｊ]. Arch Surg, 2003; 138(4)∶427.
2. 　王单松，靳大勇，楼文晖，等. 胰腺囊腺瘤和囊腺癌的诊断及外科治疗 [Ｊ]. 中华普通外科杂志， 2007； 22（1）∶55.
3. 　沈魁，钟守先，张圣道主编. 胰腺外科 [M]. 第1版. 北京：人民卫生出版社， 2000∶383~388.
4. 　吴泓，熊先泽，程南生，等. 胰腺囊腺癌的诊断（附36例报告） [Ｊ]. 中国普外基础与临床杂志， 2005； 12（5）∶509.
5. 　Warshaw AL, Compton CC, Lewandrowski K, et al. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients [Ｊ]. Ann Surg, 1990; 212(4)∶432.
6. 　魏志新，宝荣，孙智勇，等. 胰腺实性假乳头状瘤的病理特点及诊治体会 [Ｊ]. 中华普通外科杂志， 2007； 22（2）∶96.
7. 　Brugge WR, Lauwers GY, Sahani D, et al. Cystic neoplasms of the pancreas [Ｊ]. N Engl J Med, 2004; 351(12)∶1218.
8. 　Jimenez RE, Warshaw AL, Z’graggen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy [Ｊ]. Ann Surg, 1999; 230(4)∶501.
9. 　Sarr MG, Carpenter HA, Prabhakar LP, et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms? [Ｊ]. Ann Surg, 2000; 231(2)∶205.
10. 　Bassi C, Salvia R, Molinari E, et al. Management of 100 consecutive cases of pancreatic serous cystadenoma: wait for symptoms and see at imaging or vice versa? [Ｊ]. World J Surg, 2003; 27(3)∶319.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinicopathologic Features,Diagnosis and Treatment of Pancreatic Cystadenoma and Cystadenocarcinoma

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