Effect of High Intensity Focused Ultrasound on Immunity of Patients with Advanced Primary Liver Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHAI Hongjun , JIANG Lisheng , LI Ning.

Department of General Surgery, West China Hospital， Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

High intensity focused ultrasound Radio frequency ablation Primary liver cancer Immunity function

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【Abstract】ObjectiveTo investigate the effect of high intensity focused ultrasound (HIFU) on the immunity of patients with advanced primary liver cancer (PLC).
MethodsForty cases of PLC admitted to our institution from Mar. 2003 to Dec. 2003 were included in this study. Patients were divided into 2 groups and received either HIFU or radiofrequency ablation (RFA) treatment randomly. CD3, CD4, CD8, CD4/CD8, NK, IL-2, TNF were chosen to assess the immune status before and after treatment. The results were compared statistically.
ResultsThe survival rate after HIFU was 80.0%, 61.1%, 42.9%, 33.3% at 3 months, 6 months, 9 months and 1 year respectively, which was similar to that after RFA treatment. The changes of immunity parameters of CD3, CD4, CD8, CD4/CD8, NK, IL-2 and TNF were not significant after HIFU treatment. In addition, the differences of those parameters between HIFU group and RFA group were insignificant.
ConclusionThere are no detrimental effects on immunity in the early period after HIFU treatment.

Citation： ZHAI Hongjun,JIANG Lisheng,LI Ning.. Effect of High Intensity Focused Ultrasound on Immunity of Patients with Advanced Primary Liver Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(2): 178-180. doi: Copy

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2. 王文见，欧阳茂，罗亿治，等. 高强度聚焦超声对荷W256肝癌鼠局部组织中T淋巴细胞亚群的影响 [Ｊ]. 中华普通外科杂志， 2000； 15（9）∶536.
3. 王文见，罗亿治，伍烽，等. 高强度聚焦超声对21例中晚期原发性肝癌病人免疫状态的影响 [Ｊ]. 中华普通外科杂志， 2003; 18(8)∶453.
4. 卢伟，李彦豪，何晓峰，等. 经导管动脉化疗栓塞术中化疗药物剂量对患者T细胞亚群的影响 [Ｊ]. 第一军医大学学报， 2002； 22（6）∶524.
5. 秦建国，韩本立，潘世春，等. 原发性肝癌患者T淋巴细胞亚群及功能变化在肿瘤复发中的临床意义 [Ｊ]. 中华实验外科杂志， 1998； 15（2）∶11.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of High Intensity Focused Ultrasound on Immunity of Patients with Advanced Primary Liver Cancer

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