Expressions of Matrix Metalloproteinase 2 and Carbohydrate Antigen 50 in Colorectal Carcinoma, Transitional Mucosa and Normal Colorectal Mucosa and Its Clinical Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Kang ¹ , SUN Xuejun ¹ , LI Siguang ² , SHANG Weihua ¹ , JIA Pengbo ¹ , FENG Huaian. ²

Department of General Surgery, The First Affiliated Hospital, Medical College of Xi’an Jiaotong University， Xi’an 710061, China;

Corresponding author：

Keywords：

Colorectal carcinoma Transitional mucosa Matrix metalloproteinase 2 Carbohydrate antigen 50 Immunohistochemistry

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【Abstract】ObjectiveTo study the expressions of matrix metalloproteinase 2 (MMP2) and carbohydrate antigen 50 (CA50) in colorectal carcinoma, cancer-adjacent mucosa （2 cm from the nether edge of tumor）, cancerdistant mucosa （5 cm from the nether edge of tumor） and normal colorectal mucosa, and to elucidate their effects on the development of colorectal carcinoma.
MethodsThe expressions of MMP2 and CA50 were detected immunohistochemically in 40 cases of colorectal carcinoma, cancer-adjacent mucosa, cancer-distant mucosa and 10 cases of normal colorectal mucosa.
Results①The expression intensity and positive rates of MMP-2 and CA50 increased significantly in turn by normal mucosa, cancer-distant mucosa, cancer-adjacent mucosa and colorectal carcinoma. ②The expression of MMP2 was correlated with CA50 in colorectal carcinoma. ③The expression of CA50 in colorectal carcinoma was closely associated with tumor differentiation, and the expression of MMP2 in colorectal carcinoma was closely associated with differentiation and Dukes stages as well.
ConclusionOver expression of MMP2 facilitates the malignant progress of colorectal carcinoma; CA50 is a reliable marker of malignance in colorectal carcinoma; CA50 and MMP2 may have synergetic effects on the development of colorectal carcinoma.

Citation： WANG Kang,SUN Xuejun,LI Siguang,SHANG Weihua,JIA Pengbo,FENG Huaian.. Expressions of Matrix Metalloproteinase 2 and Carbohydrate Antigen 50 in Colorectal Carcinoma, Transitional Mucosa and Normal Colorectal Mucosa and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 417-420. doi: Copy

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1. Liabakk NB, Talbot I, Smith RA, et al. Matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9) type Ⅳ collagenases in colorectal cancer [Ｊ]. Cancer Res, 1996; 56(1)∶190.
2. Zeng ZS, Guillem JG. Unique activation of matrix metalloproteinase9 within human liver metastasis from colorectal cancer [Ｊ]. Br J Cancer, 1998; 78(3)∶349.
3. Kikuchi R, Noguchi T, Takeno S, et al. Immunohistochemical detection of membranetype1matrix metalloproteinase in colorectal carcinoma [Ｊ]. Br J Cancer, 2000; 83(2)∶215.
4. Adachi Y, Yamamoto H, Itoh F, et al. Contribution of matrilysin (MMP7) to the metastatic pathway of human colorectal cancers [Ｊ]. Gut, 1999; 45(2)∶252.
5. Koshiba T, Hosotani R, Wada M, et al. Involvement of matrix metalloproteinase2 activity in invasion and metastasis of pancreatic carcinoma [Ｊ]. Cancer, 1998; 82(4)∶642.
6. 杨镇主编. 肿瘤免疫学 [M]. 第1版. 武汉：湖北科学技术出版社, 1998∶68~70.
7. Takezako Y, Okusaka T, Ueno H, et al. Tumor markers for pancreatic and biliary tract cancer [Ｊ]. Gan To Kagaku Ryoho, 2004; 31(9)∶1443.
8. 刘长安, 马力文, 张淑兰, 等. 大肠癌患者血清糖链抗原CA50水平及其临床意义 [Ｊ]. 中国肿瘤临床与康复, 2001； 8（2）∶11.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions of Matrix Metalloproteinase 2 and Carbohydrate Antigen 50 in Colorectal Carcinoma, Transitional Mucosa and Normal Colorectal Mucosa and Its Clinical Significance

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