Correlation Between Homocysteine and AntiPhospholipid Antibodies and the Formation and Recurrence of Thrombus in Deep Vein._CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Yingnan , SUN Qingfeng , WANG Haitao , JIANG Weiliang

Department of Vascular, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;

Corresponding author：

Keywords：

Deep venous thrombosis Homocysteine Anti-phospholipid antibody

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【Abstract】ObjectiveTo detect the levels of homocysteine (Hcy) and anti-phospholipid antibodies (APLA) in the hematoplasma of the patients with deep venous thrombosis (DVT), discuss the reason of DVT recurrence and search for the predictors of it.
MethodsSixty cases with DVT in our department from January 2001 to April 2003 were collected, which were divided equally into two groups as primary and recurrent, and first degree relative of the 30 DVT recurrent patients were also collected. The author established a control group using 30 cases of outpatient clinic without varicose veins of lower extremity or insufficient venae profundae. Hcy was detected with fluorescence polarization immunoassay (FPIA) and APLA 〔anticardiolipin antibody, ACLA (IgG, IgM); lupus antibody (LA)〕were detected with enzyme linked immunosorbent assay (ELISA). Odds ratios (OR) were also calculated to assess the relative risk of each study group.
ResultsThe values of Hcy and ACLA （IgG， IgM） in the primary group and recurrent group were both significantly higher than those of control group and first degree relative group of DVT recurrent patients (P lt;0.01). The values of Hcy in first degree relative group of DVT recurrent patients was were also much higher than that of control group (P lt;0.05). The 90% quantity of Hcy in control group was 13.1 μmol/L and if taking it as the normal value, the number of cases exceeded this value in primary group, recurrent group and first degree relative group of DVT recurrent patients were 14, 21 and 13 and the OR of them were 2.31, 2.20 and 1.90, respectively. The positive rates of LA were not statistically significant in each group.
Conclusion The values of Hcy and APLA both rise in the hematoplasma of DVT patients. There are close relationship between the levels of Hcy and APLA and DVT. The recurrence of DVT is related to high level of Hcy and Hcy is possibly a predictor of DVT.

Citation： ZHANG Yingnan,SUN Qingfeng,WANG Haitao,JIANG Weiliang. Correlation Between Homocysteine and AntiPhospholipid Antibodies and the Formation and Recurrence of Thrombus in Deep Vein.. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 421-423. doi: Copy

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2. Haemostasis, 1996; 26（Suppl 4）∶340.
3. Arterioscler Thromb Vasc Biol, 1995; 15(9)∶1321.
4. Thromb Haemost, 1998; 80(6)∶874.
5. Hirama T, Koeffler HP. Role of the cyclindependent kinase inhibitors in the development of cancer [Ｊ]. Blood, 1995; 86(3)∶841.
6. Shipchandler MT, Moore EG. Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer [Ｊ].
7. Carreras LO, Forastiero RR. Pathogenic role of antiproteinphospholipid antibodies [Ｊ].
8. Bick RL, Baker WF. Antiphospholipid and thrombosis syndromes [Ｊ]. Semin Thromb Hemost, 1994; 20(1)∶3.
9. Bokarewa MI, Bremme K, Falk G, et al. Studies on phospholipid antibodies, APCresistance and associated mutation in the coagulation factor V gene [Ｊ]. Thromb Res, 1995; 78(3)∶193.
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11. Den Heijer M, Rosendaal FR, Blom HJ, et al. Hyperhomocysteinemia and venous thrombosis: a Metaanalysis [Ｊ].
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13. 邱玲, 鄢盛恺, 宋耀虹. 亚甲基四氢叶酸还原酶基因多态性与深静脉血栓形成 [Ｊ]. 中华检验医学杂志， 2002； 25(4)∶200.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation Between Homocysteine and AntiPhospholipid Antibodies and the Formation and Recurrence of Thrombus in Deep Vein.

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