Th1Th2 Cell and Tumor Recurrence_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SHEN Hongyan , SUN Zhijun.

Department of General Surgery, The First Affiliated Hospital, Chongqing University of Medical Science,;

Corresponding author：

Keywords：

T helper cell 1/T helper cell 2 Tumor recurrence Cytokine

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【Abstract】ObjectiveTo review the relationship between T helper cell 1/T helper cell 2 （Th1/Th2） shift and tumor recurrence.
MethodsLiteratures on Th1/Th2 shift and tumor recurrence were collected and reviewed.
ResultsTh1/Th2 shift can be detected in the host after therapy of the tumor. Tumor cells escape from host immune surveillance by altering Th1/Th2, which could lead to tumor recurrence.
ConclusionTh1/Th2 shift is related to tumor recurrence after therapy. Impelling the reverse of Th2 to Th1 and renewing the balance of T helper cells come out to be a new way for tumor therapy.

Citation： SHEN Hongyan,SUN Zhijun.. Th1Th2 Cell and Tumor Recurrence. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(4): 490-492. doi: Copy

1.	Spellberg B, Edwards JE Jr. R Type 1/Type 2 immunity in infectious diseases [J]. Clin Infect Dis， 2001; 32(1)∶76.
2.	Dong C, Flavell RA. Th1 and Th2 cells [J]. Curr Opin Hematol， 2001; 8(1)∶47.
3.	Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins [J]. J Immunol， 1986; 136(7)∶2348.
4.	Macchia D, Parronchi P, Piccinni MP, et al. In vitro infection with HIV enables human CD4+ T cell clones to induce noncognate contactdependent polyclonal B cell activation [J]. J Immunol， 1991; 146(10)∶3413.
5.	Romagnani S. Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease [J]. Int J Clin Lab Res， 1991; 21(2)∶152.
6.	Scott P. Differentiation, regulation, and death of T helper cell subsets during infection with Leishmania major [J]. Immunol Res， 1998; 17(1-2)∶229.
7.	Park AY, Scott P. IL12: keeping cellmediated immunity alive [J]. Scand J Immunol， 2001; 53(6)∶529.
8.	Nakanishi K, Yoshimoto T, Tsutsui H, et al. Interleukin18 regulates both Th1 and Th2 responses [J]. Annu Rev Immunol， 2001; 19∶423.
9.	Shibata M, Nezu T, Kanou H, et al. Decreased production of interleukin12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer [J]. J Clin Gastroenterol， 2002; 34(4)∶416.
10.	Banat GA, Christ O, Cochlovius B, et al. Tumourinduced suppression of immune response and its correction [J]. Cancer Immunol Immunother， 2001; 49(11)∶573.
11.	Real LM, Jimenez P, Kirkin A, et al. Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient [J]. Cancer Immunol Immunother， 2001; 49(11)∶621.
12.	陈绍洋, 熊利泽. 肿瘤患者手术输血新观念 [J]. 中国输血杂志, 2002； 15（5）∶366.
13.	Aoki Y, Tsuneki I, Sasaki M, et al. Analysis of Th1 and Th2 cells by intracellular cytokine detection with flow cytometry in patients with ovarian cancer [J]. Gynecol Obstet Invest， 2000; 50(3)∶207.
14.	王长印, 邹雄，车至香, 等. 消化道肿瘤患者Thl／Th2细胞的监测和分析 [J]. 现代免疫学， 2004； 24（1）∶72.
15.	Singh HP, Gupta S, Raina V. Restoration of naive cell repertoire in the appropriate cytokine milieu: a model for preventing cancer relapses [J]. Med Hypotheses， 2002; 58(6)∶554.
16.	Jensen M, Tawadros S, Sedlacek HH, et al. NK cell depletion diminish tumourspecific B cell responses [J]. Immunol Lett， 2004; 93(2-3)∶205.
17.	MartinFontecha A, Thomsen LL, Brett S, et al. Induced recruitment of NK cells to lymph nodes provides IFNgamma for T(H)1 priming [J]. Nat Immunol， 2004; 5(12)∶1260.
18.	Nishimura T, Nakui M, Sato M, et al. The critical role of Th1dominant immunity in tumor immunology [J]. Cancer Chemother Pharmacol， 2000; 46（Suppl）∶S52.
19.	Matar P, Rozados VR, Gervasoni SI, et al. Th2/Th1 switch induced by a single low dose of cyclophosphamide in a rat metastatic lymphoma model [J]. Cancer Immunol Immunother， 2002; 50(11)∶588.
20.	Oka H, Emori Y, Kobayashi N, et al. Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses [J]. Int Immunopharmacol， 2001; 1(3)∶521.

1. Spellberg B, Edwards JE Jr. R Type 1/Type 2 immunity in infectious diseases [J]. Clin Infect Dis， 2001; 32(1)∶76.
2. Dong C, Flavell RA. Th1 and Th2 cells [J]. Curr Opin Hematol， 2001; 8(1)∶47.
3. Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins [J]. J Immunol， 1986; 136(7)∶2348.
4. Macchia D, Parronchi P, Piccinni MP, et al. In vitro infection with HIV enables human CD4+ T cell clones to induce noncognate contactdependent polyclonal B cell activation [J]. J Immunol， 1991; 146(10)∶3413.
5. Romagnani S. Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease [J]. Int J Clin Lab Res， 1991; 21(2)∶152.
6. Scott P. Differentiation, regulation, and death of T helper cell subsets during infection with Leishmania major [J]. Immunol Res， 1998; 17(1-2)∶229.
7. Park AY, Scott P. IL12: keeping cellmediated immunity alive [J]. Scand J Immunol， 2001; 53(6)∶529.
8. Nakanishi K, Yoshimoto T, Tsutsui H, et al. Interleukin18 regulates both Th1 and Th2 responses [J]. Annu Rev Immunol， 2001; 19∶423.
9. Shibata M, Nezu T, Kanou H, et al. Decreased production of interleukin12 and type 2 immune responses are marked in cachectic patients with colorectal and gastric cancer [J]. J Clin Gastroenterol， 2002; 34(4)∶416.
10. Banat GA, Christ O, Cochlovius B, et al. Tumourinduced suppression of immune response and its correction [J]. Cancer Immunol Immunother， 2001; 49(11)∶573.
11. Real LM, Jimenez P, Kirkin A, et al. Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient [J]. Cancer Immunol Immunother， 2001; 49(11)∶621.
12. 陈绍洋, 熊利泽. 肿瘤患者手术输血新观念 [J]. 中国输血杂志, 2002； 15（5）∶366.
13. Aoki Y, Tsuneki I, Sasaki M, et al. Analysis of Th1 and Th2 cells by intracellular cytokine detection with flow cytometry in patients with ovarian cancer [J]. Gynecol Obstet Invest， 2000; 50(3)∶207.
14. 王长印, 邹雄，车至香, 等. 消化道肿瘤患者Thl／Th2细胞的监测和分析 [J]. 现代免疫学， 2004； 24（1）∶72.
15. Singh HP, Gupta S, Raina V. Restoration of naive cell repertoire in the appropriate cytokine milieu: a model for preventing cancer relapses [J]. Med Hypotheses， 2002; 58(6)∶554.
16. Jensen M, Tawadros S, Sedlacek HH, et al. NK cell depletion diminish tumourspecific B cell responses [J]. Immunol Lett， 2004; 93(2-3)∶205.
17. MartinFontecha A, Thomsen LL, Brett S, et al. Induced recruitment of NK cells to lymph nodes provides IFNgamma for T(H)1 priming [J]. Nat Immunol， 2004; 5(12)∶1260.
18. Nishimura T, Nakui M, Sato M, et al. The critical role of Th1dominant immunity in tumor immunology [J]. Cancer Chemother Pharmacol， 2000; 46（Suppl）∶S52.
19. Matar P, Rozados VR, Gervasoni SI, et al. Th2/Th1 switch induced by a single low dose of cyclophosphamide in a rat metastatic lymphoma model [J]. Cancer Immunol Immunother， 2002; 50(11)∶588.
20. Oka H, Emori Y, Kobayashi N, et al. Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses [J]. Int Immunopharmacol， 2001; 1(3)∶521.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Th1Th2 Cell and Tumor Recurrence

Abstract Full text Figures/Tables Video References Cited by

Format

Content