【Abstract】　Objective　To investigate the expression of tumor associated glycoprotein-72 （TAG-72） in human breast cancer cells. Methods　Two breast cancer cell lines MCF-7 and Bcap-37 were cultured and prepared. TAG-72 expressions in MCF-7 and Bcap-37 were detected immunochemically with anti-TAG-72 single chain variable fragment (scFv). Results　TAG-72 was positively expressed in MCF-7 cells but negatively expressed in Bcap-37 cells. Conclusion　Tumor associated antigen TAG-72 is expressed in certain human breast cancer cells, which indicate TAG-72 may be used as a tumor maker and anti-TAG-72 scFv may play a role in the diagnosis and treatment of breast cancer.

Citation： XU Hongyong,XU Li,LI Kaizong,GAO Jianhong.. Expression of Anti-Tumor-Associated Glycoprotein-72 Single Chain Variable Fragment in Human Breast Cancer Cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2006, 13(5): 540-541下转549. doi: Copy