Effects of Growth Hormone on Human Colonic Cancer Cells_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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ZHOU Jianping , LIU Qi.

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Keywords：

Colonic cancer Growth hormone

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【Abstract】Objective To investigate the effects of human growth hormone (GH) on colonic cancer cells to provide experimental evidence about the GH safety in colonic cancer therapy.
Methods The nude mouse model of colonic carcinoma induced with SW480 cell line was established to observe the effects of GH on the transplanted carcinoma. GH and 5-FU were administered to SW480 cells cultured in vitro to observe the cell growth with MTT method.
Results The volume, average diameter and weight of the transplanted carcinoma in GH group were significantly higher than those in control group（P＜0.05）. In vitro, the value of A in GH group was significantly higher than control group （P＜0.01), but the value of A in 5-FU+GH group was lower than control group（P＜0.01）.
Conclusion GH can promote colonic cancer cell growth; GH combined with cell cycle specific chemotherapeutic drugs is safe in colonic cancer therapy and may be used as a promoter of chemotherapy.

Citation： ZHOU Jianping,LIU Qi.. Effects of Growth Hormone on Human Colonic Cancer Cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2005, 12(4): 390-392. doi: Copy

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1. Swerdlow AJ, Higgins CD, Adlard P，et al. Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study [Ｊ]. JPLancet, 2002; 360(9329)∶273.
2. Jauch KW, Heiss MM, Gruetzner U, et al. Prognostic significance of bone marrow micrometastases in patients with gastric cancer [Ｊ]. J Clin Oncol, 1996; 14(6)∶1810.
3. Hermanek P. pTNM and residual tumor classifications: problems of assessment and prognostic significance [Ｊ]. World J Surg, 1995; 19(2)∶184.
4. Cohen P, Clemmons DR, Rosenfeld RG. Dose the GHIGF axis play a role in cancer pathogenesis? [Ｊ]. Growth Horm IGF Res, 2000; 10(6)∶297.
5. Morante J, VallejoCremades MT, GomezGarcia L, et al. Differential action of growth hormone in irradiated tumoral and nontumoral intestinal tissue [Ｊ]. Dig Dis Sci, 2003; 48(11)∶2159.
6. Bustin SA, Jenkins PJ. The growth hormoneinsulinlike growth factorI axis and colorectal cancer [Ｊ]. Trends Mol Med, 2001; 7(10)∶447.
7. Busto R, Schally AV, Varga JL, et al. The expression of growth hormonereleasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas [Ｊ]. Proc Natl Acad Sci USA, 2002; 99(18)∶11866.
8. 祁晓平，黎介寿，陈彻. 人生长激素对人结肠癌细胞LS174T增殖周期的影响 [Ｊ]. 肠外与肠内营养， 2001; 8(1)∶8.
9. 祁晓平，黎介寿，陈彻. 人生长激素对结肠癌细胞株细胞周期动力学的影响 [Ｊ]. 肠外与肠内营养， 2000; 7(2)∶83.
10. 陈嘉勇，甘平，徐鹏远，等. 生长激素对老年消化道肿瘤患者术后蛋白分解代谢和免疫功能的影响 [Ｊ]. 中国老年学杂志， 2000; 20(5)∶162.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Growth Hormone on Human Colonic Cancer Cells

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