Objective To observe the efficacy of all trans retinoic acid (ATRA) combined with 5-Fu on treating subcutaneously implanted gastric carcinoma SGC 7901 in the nude mice.
Methods Thirty-two nude mice bearing tumor were randomly divided into 4 groups: control group (group A), ATRA 1 000 μg/d orally taken group (group B), 5-Fu 27 mg/kg group peritoneally injected (group C), 5-Fu 13.5 mg/kg combined with ATRA 500 μg/d group (group D).
Results Significant inhibition of tumor growth was shown in the group B, group C and group D as compared with group A (Ｐ＜0.01), with the tumor growth inhibition rate and the tumor weight inhibition rate at the 7 weeks after the treatment being 56.88%, 49.00%, 70.00% and 56.10%, 51.64%, 76.95%.
Conclusion ATRA combined with 5-Fu can enhance the effects of 5-Fu in treating gastric carcinoma.
Citation：
HUANG Chengliang,LIU Houdong,WANG Daike.. THE EFFECT OF ALL TRANS RETINOIC ACID COMBINED WITH 5-FU IN TREATING EXPERIMENTAL GASTRIC CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(1): 10-12. doi:
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- 1. 沈月霞， 何振平， 吴兆平等. 维甲酸对胃癌细胞的诱导分化作用 〔Ｊ〕. 中华肿瘤杂志， 1994； 16(1)∶15.
- 2. 黄承良， 王代科， 刘宝华. 全反式维甲酸对人胃腺癌裸小鼠移植瘤的抗增殖及诱导分化作用 〔Ｊ〕. 中国普外基础与临床杂志， 1998； 5(3)∶129.
- 3. Breitman J, He R. Combination of retinoic acid with either sodiumbutyrate dimethylsulfoxide of hexamethyhene bisacetmide synergistically induce differentiation of the human myeloid leukenia cell line HL60 〔Ｊ〕. Cancer Res, 1990; 50(3)∶6268.
- 4. Peek K, Blllag W. Potentiation of retinoid induced differentiation of HL60 and U937 cell line by cytokines 〔Ｊ〕. Eur J Cancer, 1991; 27(1)∶53.
- 5. 韩锐主编. 肿瘤化学预防及药物治疗 〔Ｍ〕. 北京医科大学中国协和医科大学联合出版社， 1991∶64～415.
- 6. Lotan R, Lotan D. Inhibitory of retinoic acid of retihylacetate on the growth of untransformed and tumor cell in vitro 〔Ｊ〕. J Natl Cancer Inst, 1987; 59(6)∶1717.
