THE RELATION BETWEEN RETINOBLASTOMA GENE EXPRESSION AND BIOLOGICAL CHARACTERISTICS OF GALLBLADDER CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

MA Hongbing ¹ , WANG Zhuoren ² , SHI Jingsen ² , et al. ¹

Department of Cancer Surgery, The Second Affiliated Hospital, Xi′an University of Medical Sciences, Xi′an 710004;

Corresponding author：

Keywords：

Gallbladder carcinoma Retinoblastoma gene Immunohistochemistry

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the relation between retinoblastoma (Rb) gene expression and biological characteristics of gallbladder carcinoma.
Methods The expression of Rb protein in tissues of 41 cases of gallbladder carcinoma, 7 cases of gallbladder papilloma, and 14 cases of cholecystitis were detected by immunohistochemical staining of SP with polyclonal antibody.
Results The rate of positive staining was 58.7% in gallbladder carcinoma which was significantly lower than that in cholecystitis and gallbladder papilloma (100%). There was a significant difference of Rb protein expression among the low, moderate and high differentiations and so was between S5, S4, S1, S2 and S3 stage (Ｐ＜0.05).
Conclusion It sugests that expression or non-expression of Rb gene is closely related to the malignant potential invasiveness and prognosis of gallbladder carcinoma.

Citation： MA Hongbing,WANG Zhuoren,SHI Jingsen,et al.. THE RELATION BETWEEN RETINOBLASTOMA GENE EXPRESSION AND BIOLOGICAL CHARACTERISTICS OF GALLBLADDER CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 87-88. doi: Copy

1.	Li SB, Schwartz PE, Lee WH, et al. Allele loss at the retinoblastoma locus in human orarian cancer 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(5)∶637.
2.	Hinds PW, Dowdy SF, Eaton EN, et al. Function of a human cyclin gene as an oncogene 〔Ｊ〕. Proc Natl Acad Sci USA, 1994; 91(2)∶709.
3.	Shapiro JL, Edwards CD, Kobzik L, et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines 〔Ｊ〕. Cancer Res, 1995; 55(3)∶505.
4.	Harbour JW, Lai SL, Whang Peng, et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC 〔Ｊ〕. Sci, 1988; 241(4863)∶353.
5.	Constancia M, Seruca R, Carneiro F, et al. Retinoblastoma gene structure and product expression in human gastric carcinomas 〔Ｊ〕. Br J Cancer, 1994; 70(5)∶1018.
6.	Lee WH, Shew JY, Hong FD, et al. The retioblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity 〔Ｊ〕. Nature, 1987; 329(6140)∶642.
7.	Ruggeri B, Zhang SY, Caamano J, et al. Human Pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb1 tumor suppressor genes 〔Ｊ〕. Oncogene, 1992; 7(8)∶1503.
8.	Xu HJ, Hu SX, Cagle PT, et al. Aesence of retinoblastoma protein expression in primary nonsmallcell lung carcinomas 〔Ｊ〕. Cancer Res, 1991; 51(10)∶2735.

1. Li SB, Schwartz PE, Lee WH, et al. Allele loss at the retinoblastoma locus in human orarian cancer 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(5)∶637.
2. Hinds PW, Dowdy SF, Eaton EN, et al. Function of a human cyclin gene as an oncogene 〔Ｊ〕. Proc Natl Acad Sci USA, 1994; 91(2)∶709.
3. Shapiro JL, Edwards CD, Kobzik L, et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines 〔Ｊ〕. Cancer Res, 1995; 55(3)∶505.
4. Harbour JW, Lai SL, Whang Peng, et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC 〔Ｊ〕. Sci, 1988; 241(4863)∶353.
5. Constancia M, Seruca R, Carneiro F, et al. Retinoblastoma gene structure and product expression in human gastric carcinomas 〔Ｊ〕. Br J Cancer, 1994; 70(5)∶1018.
6. Lee WH, Shew JY, Hong FD, et al. The retioblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity 〔Ｊ〕. Nature, 1987; 329(6140)∶642.
7. Ruggeri B, Zhang SY, Caamano J, et al. Human Pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb1 tumor suppressor genes 〔Ｊ〕. Oncogene, 1992; 7(8)∶1503.
8. Xu HJ, Hu SX, Cagle PT, et al. Aesence of retinoblastoma protein expression in primary nonsmallcell lung carcinomas 〔Ｊ〕. Cancer Res, 1991; 51(10)∶2735.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE RELATION BETWEEN RETINOBLASTOMA GENE EXPRESSION AND BIOLOGICAL CHARACTERISTICS OF GALLBLADDER CARCINOMA

Abstract Full text Figures/Tables Video References Cited by

Format

Content