Objective To defect the level of platelet antibody-IgG (PA-IgG) in patients with congestive splenomegaly and hypersplenism and the change of PA-IgG level after splenectomy and subtotal splenectomy.
Methods Twenty four cases of congestive splenomegaly and hypersplenism were investigated.
Results The level of PA-IgG in 24 cases were higher than normal range (Ｐ＜0.01), while the platelet count were lower than normal range and there was a significant negative correlation between the level of PA-IgG and platelet count (r＝-0.4747, Ｐ＜0.05). After subtotal splenectomy or splenectomy, the level of PA-IgG descended, the platelet count raised and the negative correlation between the level of PA-IgG and platelet count disappeared. Conclusion The results suggest that there is a immunoregulation between PA-IgG and platelet. Perhaps spleen has some relation with the immunoregulation.
Citation：
LI Xiaoyang,MA Hong min.. CHANGES OF PLATELET ANTIBODY-IgG LEVEL IN PATIENTS WITH CONGESTIVE SPLENOMEGALY AND HYPERSPLENISM AFTER DIFFERENT SPLENIC OPERATIONS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(2): 100-102. doi:
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- 1. Douglas F, Karpatkin S. Cumulative experience with a simplified solidphase radioimmunoassay for the detection of bound antiplatelet IgG, serum atutoand drugdependent 〔Ｊ〕. Blood, 1982; 60(4)∶807.
- 2. Yesus YW, Scrivner DL, Mitchell MA. Simplified micro ELISA procedure for the measurement of plateletassociated IgG (PAIgG) 〔Ｊ〕. Am J Clin Pathol, 1984; 81(1)∶81.
- 3. HillZobel RL, McCandless R, Kang SA, et al. Organ distribution and fate of human platelet: studies of asplenic and splenomegalic patients 〔Ｊ〕. Am J Hemal, 1986; 23(3)∶231.
- 4. Wadenvik H, Denfors I, Kutti J. Splenic blood flow and intrasplenic platelet kinetics in relation to spleen volume 〔Ｊ〕. British J of Haematology, 1987; 67(2)∶181.
- 5. 杜心， 王振义. 血液病脾脏组织研究的进展 〔J〕. 国外医学输血及血液学分册， 1987； 10(2)∶73.
