• Department of General Surgery, The First Affiliated Hospital, Nanjing University of Medical Sciences, Nanjing 210029;
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Objective  To probe the change of the structure and function of the small bowel by injection of different drugs (verapamil, energy compounds or normal saline) via the superior mesenteric artery (SMA) injections.
Methods  The model of the small intestine ischemia/reperfusion (I/R) injury was made in grey rabbits. Free calcium concentration in mitochondria of the small intestine was determined, and the ultrastructural change was also observed by electron microscopy at the very time of occlusion, 60 minutes after occlusion and 30 minutes after reperfusion.
Results  The free calcium concentration in mitochondria was more declined in verapamil group (2.976±0.410 nmol/mg.prot) than in N.S. group (4.234±0.542 nmol/mg.prot), P<0.01, at 60 minutes after occlusion. At 30 minutes after reperfusion, free calcium concentration in mitochondria was more decreased in energy compunds group (2.401±0.323 nmol/mg.prot) and verapamil group (3.847±0.610 nmol/mg.prot) than in the N.S. group (5.981±1.031 nmol/mg.prot).
Conclusion  Verapamil and energy compouds have protective effects on the functions and ultrastructures of the I/R of small intestine.

Citation: CHEN Guoy,NI Shaozhong.. EFFECTS OF VERAPAMIL AND ENERGY COMPOUNDS ON STRUCTURAL AND FUNCTIONAL CHANGES OF SMALL BOWEL′S IN RABBITS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 135-137. doi: Copy