EXPRESSION OF NM23, CD44H AND CD44V6 IN GASTRIC CARCINOMA AND ITS SIGNIFICANCE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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The 401st Hospital of PLA, Qingdao 266071;

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Stomach neoplasm Anti-metastatic oncogene Cell adhesion molecules Prognosis

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Objective To study the relationship between expression of nm23, CD44 in gastric carcinoma and lymph-node metastasis and prognosis.
Methods Expression of nm 23, CD44H and CD44V6 in 105 cases of gastric carcinoma were assayed by immunohistochemistry. Among them, 59 cases were followed up.
Results The incidences of nm23, CD44H and CD44V6 protein positivity in gastric carcinoma were 44.8%, 54.3% and 48.6% respectively. The positive expression of nm23, CD44V6 protein in human gastric carcinoma tissues was related to the differentiation, depth of invasion, TNM stage and prognosis (Ｐ＜0.05), but expression of CD44H was not correlated with other clinicopathologic indices. The reactivity to these three antibodies were correlate with metastasis of lymph nodes (Ｐ＜0.01 for CD44V6 and Ｐ＜0.05 for nm23, CD44H).
Conclusion Expression of the standard form of CD44 (CD44H) might be useful in observing the progression of the disease, wile CD44V6 and nm23 hold promise as a prognostic indicator.

Citation： JIN Weizhong,YANG Donghui,ZHAO Jingxuan,et al.. EXPRESSION OF NM23, CD44H AND CD44V6 IN GASTRIC CARCINOMA AND ITS SIGNIFICANCE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(3): 141-143. doi: Copy

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1. 胡继康，陈维鹏，韩乃刚主编. 现代肿瘤外科学〔M〕. 第1版. 北京：中国科学技术出版社， 1994∶327～328.
2. Steeg PA, Bevilacqua G, Kopper L, et al. Evidence for a novel gene associated with a low tumor metastatic potential 〔Ｊ〕. J Natl Cancer Inst, 1988; 80(2)∶204.
3. Hennessy C, Henry JA, May FEB, et al. Expression of the antimetastic gene nm23 in human breast cancer: an association with good prognosis 〔Ｊ〕. J Natl Cancer Inst, 1991; 83(2)∶281.
4. Kodera Y, Isobe K, Yamanchi M, et al. Expression of nm23H1 RNA levels in human gastric cancer tissues: a negaive correlation with nodal metastasis 〔Ｊ〕. Cancer, 1994; 73(2)∶259.
5. Nakayama H, Yasui W, Yokozaki H, et al. Reduced expression of nm23 is associated with metastasis of human gastric carcinomas 〔Ｊ〕. Jpn J Cancer Res, 1993; 84(2)∶184.
6. Harn HJ, Ho LI, Chang JY, et al. Differential expression of the human metastasis adhesion molecule CD44V in normal and carcinomatous stomach mucosa of Chinese subjects 〔Ｊ〕. Cancer, 1995; 75(5)∶1065.
7. Mayer B, Jauch KW, Gunthert U, et al. Denovo expression of CD44 and survival in gastric cancer 〔Ｊ〕. Lancet, 1993; 342(8878)∶1019.
8. Streit M, Schmidt R, Hilgenfeld RU, et al. Adhesion receptors in malignant transformation and dissemination of gastrointestinal tumors 〔Ｊ〕. J Mol Med, 1996; 74(5)∶253.
9. Hong RL, Lee WJ, Shun CT, et al. Expression of CD44 and its clinical implication in diffusetype and intestinaltype gastric adenocarcinomas 〔Ｊ〕. Oncology, 1995; 52(4)∶334.
10. Tahara E, Semba S, Tahara H. Molecular biological observations in gastric cancer 〔Ｊ〕. Semin Oncol, 1996; 23(3)∶307.
11. Schildberg FW, Meyer G, Piltz S, et al. Surgical treatment of tumor metastasis: general considerations and results 〔Ｊ〕. Surg Today, 1995; 25(1)∶1.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPRESSION OF NM23, CD44H AND CD44V6 IN GASTRIC CARCINOMA AND ITS SIGNIFICANCE

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